THE MANAGEMENT OF RHEUMATOID ARTHRITIS IN ADULTS

GC-induced hyperglycaemia is a well-recognised complica- tion of long-term GC use [64]. It is known that patients with
active RA have impaired glucose handling and that glucose metabolism may be affected directly or indirectly by inflamma- tory mediators [65]. Several studies have demonstra[r]

Discussion
Our results demonstrate that RasGRF1 regulates spontane- ous MMP-3 production in RA FLS, and suggest that overex- pression of RasGRF1 sensitizes signaling pathways promoting MMP-3 production and joint destruction in RA. RasGRF1 specifically activates H-Ras, but no[r]

The bone destruction disease including osteoporosis and rheumatoid arthritis are caused by the imbalance between osteoblastogenesis and osteoclastogenesis. Inhibition of the NF-κB pathway was responsible for decreased osteoclastogenesis.

This prospective study was designed to analyze the incidence and the factors associated with impairment in left ventricular systolic function (LVSF) overtime in patients with rheumatoid arthritis (RA) without overt cardiac disease. In particular, we verified the hypothesis that a relationship betwee[r]

Although we were not able to test this hypothesis directly in our data (because the relevant reproductive variables were not available), a review of the literature gives some clues. In studies conducted in women-only cohorts, the presence of as[r]

in the synovial fluid leading to impaired uptake. While Wilton et al. [8] postulated that this decreased ability to ingest and kill bacteria could be due to deficiency in the expression of C'3 on the PMN in the synovial fluid. How- ever, more r[r]

and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain pro- moter as a model. Mol Cell Biol 1997, 17 :4589-4596.
23. Haas J-P, Nevinny-Stickel C, Shoenwald U, Truckenbrodt H, Suschke J, Albert ED: Susceptible and p[r]

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Arthritis Research & Therapy Vol 6 No 2 Bombardieri et al.
Because the classic clinical picture of RA is not entirely helpful in differential diagnosis, other diagnostic tools, such as the detection of serologic abnormalities in se[r]

Although the contribution of adenosine to the mechanism of action of methotrexate is well accepted, it is still unclear which adenosine receptors participate in the effect of methotrexate. Results of early studies, using pharmacological[r]

Objectives: To evaluate serum levels of tumor necrosis factor (TNF)-α in rheumatoid arthritis (RA) patients and to assess the correlations of this cytokine with clinical and laboratory parameters.

It is intriguing to speculate that alterations in Src-PTK/FAK complex formation are present in RA-SFs, and it is clear that this aspect of fibroblasts activation requires further attention. By focusing on cytoskeletal rearrangement and cell migration, Zeng and coworkers [4] addr[r]