TRACKING THE ORIGIN OF SIMULTANEOUS ENDOMETRIAL AND OVARIAN CANCER BY NEXTGENERATION SEQUENCING – A CASE REPORT

one including patients with endometrial endometrioid carcinomas and one consisting of ovarian endometrioid carcinomas [4]. The authors suggest that although the same genes are affected in both cancers the mutation patterns differ possibly due to th[r]

148–154. 76. Sawada, M.; Okudaira, Y.; Matsui, Y.; Shimizu, Y. Immunosuppressive acidic protein in patients with ovarian cancer. Cancer 1983, 52, 2081–2085. 77. Castelli, M.; Romano, P.; Atlante, G.; Pozzi, M.; Ferrini, U. Immunosuppressive acidic protein (IAP) and CA 125[r]

Cancer antigen (CA) 125 (CA-125) is used in ovarian cancer detection and monitoring, whose serum level has a positive correlation with tumor stage. The aim of this study was to obtain a prediction metastasis equation in a group of patients with ovarian cancer based on Ca-125

The 2010 guidelines of the French National Cancer Institute (INCa) classify patients with endometrial cancer into three risk groups for lymph node invasion and recurrence on the basis of MRI and histological analysis of an endometrial specimen obtained preoperatively. The classification guides thera[r]

ging, a MRI sequencing is done for the definit ive diag-nosis. In our experience , we believe that most brachialismuscle ruptures can be treated conservatively with earlyactive mobilization.ConclusionsTo diagnose peripheral muscle ruptures, ultrasound exam-ination can be an adeq[r]

The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an increased risk of colon cancer. In this study we assessed the impact of MDM2 del1518 on r[r]

a tumour of a specific tissue is temporospatially differentfrom the expression seen in the normal tissue, and/orthe increased expression of HOX genes that are usuallyexpressed at lower levels in the normal tissue. In addi-tion, epigenetic c han[r]

Because they were correlated with increased disease bur- den, platelet count and plasma fibrinogen level could be considered to be predictors of surgical outcomes [2 – 6, 16]. Ma et al. [4] found that epithelial ovarian cancer patients with thrombocytosis have a gr[r]

To assess the effect of visceral adiposity on clinical and pathological characteristics in patients with endometrial cancer. Methods: A retrospective review of medical documentation was performed in surgically treated endometrial cancer patients from January to November 2015 in our institution.

Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP,Smith GC, Ashworth A: Targeting the DNA repair defect in BRCA mutantcells as a therapeutic strategy. Nature 2005, 434:917-921.9. Banerjee S, Kaye SB, Ashworth A: Making the best of PARP inhi[r]

pole of the ipsilateral adrenal gland [1,12,13].There are few reports of a high TA origin in the lit-erature. Shinohara et al. found a TA originating 1 cmsuperior to the origin of the inferior phrenic artery [3].After a<[r]

As ovarian cancer stem cells (CSCs) are responsible for tumor initiation, invasion, metastasis, and chemo-resistance, new stratagems that selectively target ovarian CSCs are critically significant. Our previous work have demonstrated that ovarian cancer spheroid cells are tumorigenic and chemo-resis[r]

Conclusion
The sequencing of different cancer genomes allows identi- fication and characterization of mutated genes in cancer samples. However, the development of genome-based therapies requires greater knowledge of the s[r]

Davies PJ: Coordinate regulation of the production and signaling ofretinoic acid by estrogen in the human endometrium. J Clin EndocrinolMetab 2003, 88:2157-2163.27. Clagett-Dame M, DeLuca HF: The role of vitamin A in mammalianreproduction an[r]

Prior studies have described a reduced risk of developing ovarian cancer with the use of oral contraceptives. In this context, we decided to examine if oral contraceptive use prior to a diagnosis of ovarian cancer is associated with better overall and progression-free survival.

Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse.

The facts that LPA is present at high concentration in ovarian cancer patients’ ascites and it may serve as a stimulator to cell migration, implicate the role of LPA in the ovarian cancer metastasis. Since LPA mediates various biological functions through its interaction with LPA receptors, we aim t[r]

Cancer of the ovary is mostly discovered at a late stage and cannot be removed by surgery alone. Therefore surgery is usually followed by adjuvant chemotherapy. However, few reliable biomarkers exist to predict response to chemotherapy of ovarian cancer.

corticosteroid or other corticosteroid-like drug therapy.Different procedures have reported in the literature fortreatment of bilateral femoral neck fracture include insitu fixation, open reduction and internal fixation, openfixation with valgus intertrochanteric osteotomy [13][r]

No screening programs are available for ovarian or endometrial cancer. One reason for this is the low incidence of the conditions, resulting in low positive predictive values for tests, which are not very specific. One way of addressing this problem might be to use risk factors to define subpopulati[r]