GENE METHYLATION PROFILE OF GASTRIC CANCEROUS TISSUE ACCORDING TO TUMOR SITE IN THE STOMACH

There is considerable information on the methylation of the promoter regions of different genes involved in gastric carcinogenesis. However, there is a lack of information on how this epigenetic process differs in tumors originating at different sites in the stomach.

Pathological findings
The histopathological evaluation of the incisional biopsy material showed a tumor growth of mesenchymal charac- ter with cellular appearance. The tumor consisted of cells with spindle character forming non-marked storifo[r]

WITH THE AIM OF FINDING HYPERMETHYLATION AT CPG ISLANDS OF PROMOTER OF BRCA1 GENE, _ BELONGED TO THE TUMOR SUPPRESSOR GENE FAMILY, AS THE BIOMARKER FOR BREAST CANCER IN VIETNAMESE POPULA[r]

Molecular characterization of circulating tumor cells (CTC) is promising for personalized medicine. We aimed to identify a CTC gene expression profile predicting outcome to first-line aromatase inhibitors in metastatic breast cancer (MBC) patients.

FOXO4, a member of the FOXO family of transcription factors, is currently the focus of intense study. Its role and function in gastric cancer have not been fully elucidated. The present study was aimed to investigate the expression profile of FOXO4 in gastric cancer and the effect of FOXO4 on cancer[r]

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Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile in endometrial carcinoma.

The peptide hormone gastrin exerts a growth-promoting effect in both normal and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 receptor (CCKBR/CCK2R). Although a substantial part of the gastric adenocarcinomas express gastrin and CCKBR, the role of gastrin i[r]

The aforementioned data prompted us to analyze DDC mRNA expression in HNSCC and adjacent non-cancerous tissue specimens resected from patients hav-ing malignant tumors in larynx, pharynx[r]

The tumor suppressor gene CDH1 is critical for intercellular adhesion. In our previous work, we reported a nonfunctional CDH1 transcript that lacks the final 83 base pairs of exon 8 (1054del83). In this work, we probed the role of histone epigenetic modifications as well as DNA methylation in select[r]

The aim of this study was to identify critical gene pathways that are associated with lung cancer metastasis to the brain. Methods: The RNA-Seq approach was used to establish the expression profiles of a primary lung cancer, adjacent benign tissue, and metastatic brain tumor from a single patient.

Effects of STC-1 on HUVEC proliferation, migration and tube formation in vitro
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Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TATE) in human cancers remains controversial.

Note The way that the Server Explorer and toolbox icons are laid out on the side of the screen varies according to how you set the Profile option in the My Profile settings on the Start [r]

Diagnosis of malignant pleural mesothelioma (MPM) remains a challenge, especially when resources in pathology are limited. The study aimed to evaluate cost-effective tumor markers to predict the probability of MPM in plasma samples in order to accelerate the diagnostic workup of the tissue of potent[r]

DNA was stored at − 20°C until use. High-resolution
melting (HRM) profile analysis, a real-time florescence- based polymerase chain reaction method, was used to measure methylation status of LINE-1 repetitive se- quences, as a surrogate measure of global DNA meth[r]

We aimed to assess individual and area-level determinants of gastric cancer screening participation. There are differences in gastric cancer screening attendance according to both individual and regional area characteristics.

Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) has been found to promote BC cell proliferation and invasion by regulating the microRNA (miR)-101/zinc-finger enhancer binding axis i[r]

To determine the extent of DNA methylation of parvalbumin gene (PVALB) promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls.

Long interspersed nucleotide element 1 (LINE-1) hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC). To assess intra-patient heterogeneity of LINE-1 methylation in CRC and to understand its biological relevance in invasion and metastasis, we evaluated the LINE-1[r]