TUMOUR SUPPRESSOR GENE METHYLATION AND CERVICAL CELL FOLATE CONCENTRATION ARE DETERMINANTS OF HIGH-RISK HUMAN PAPILLOMAVIRUS PERSISTENCE: A NESTED CASE CONTROL STUDY
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-r...":
Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk human papillomavirus persistence: A nested case control study
Persistent infection with one or more high-risk human papillomavirus [HR-HPV] types increases the risk of intraepithelial neoplasia and cervical cancer. A nested case–control study was conducted to investigate the importance of cervical cell folate concentration and tumour suppressor gene methylatio[r]
A RARE CHD5 HAPLOTYPE AND ITS INTERACTIONS WITH ENVIRONMENTAL FACTORS PREDICTING HEPATOCELLULAR CARCINOMA RISK
CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC).
HPV-16 IMPAIRS THE SUBCELLULAR DISTRIBUTION AND LEVELS OF EXPRESSION OF PROTEIN PHOSPHATASE 1Γ IN CERVICAL MALIGNANCY
We originally considered that the PP1 γ /hScrib com- plex might be a general target for HPV-16 E6, based on our previous studies showing complex formation be- tween hScrib and PP1 γ . However, analysis of the expres- sion patterns of PP1 γ and hScrib in cervical[r]
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EFFECT OF A GROUP EDUCATIONAL INTERVENTION ON RURAL CHINESE WOMEN’S KNOWLEDGE AND ATTITUDES ABOUT HUMAN PAPILLOMAVIRUS (HPV) AND HPV VACCINES
Statistics regarding HPV prevalence and cervical cancer rates in rural China are high, however, low levels of HPV awareness and HPV-related knowledge pose a great challenge for cervical cancer control.
DOES ANTI-P53 ANTIBODY STATUS PREDICT FOR CLINICAL OUTCOMES IN METASTATIC COLORECTAL CANCER PATIENTS TREATED WITH FLUOROPYRIMIDINE, OXALIPLATIN, PLUS BEVACIZUMAB AS FIRST-LINE CHEMOTHERAPY?
P53 gene mutation is widely known as one of the determinants of impaired chemosensitivity. p53 is a tumor-suppressor protein in humans encoded by the TP53 gene. Some studies have shown that TP53 gene mutation and accumulation of the p53 protein are closely related with serum anti-p53 antibody positi[r]
3’UTR polymorphism of Thymidylate Synthase gene increased the risk of persistence of pre-neoplastic cervical lesions
Cervical cancer is caused by high-risk Human Papillomavirus (hr-HPV) infection associated with cofactors that has been analyzed as predictors of the remission or persistence of cytological abnormalities remission or persistence.
CHAPTER 080. CANCER CELL BIOLOGY AND ANGIOGENESIS (PART 7) DOCX
the action of geranylgeranyl transferase-I (GGT-I), which results in restoration of Ras function. Thus, while FTIs are likely to have antitumor activity in select human cancers, their mechanism of action appears to occur by inhibition of farnesylation of<[r]
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TOPICAL IMIQUIMOD TREATMENT OF RESIDUAL OR RECURRENT CERVICAL INTRAEPITHELIAL NEOPLASIA (TOPIC-2 TRIAL): A STUDY PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL
Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical.
HIGH-RISK ORAL LEUKOPLAKIA IS ASSOCIATED WITH ABERRANT PROMOTER METHYLATION OF MULTIPLE GENES
Early detection of oral squamous cell carcinomas (OSCCs) is urgently needed to improve the prognosis and quality of life (QOL) of patients. Oral leukoplakias (OLs), known as the most common premalignant lesions in the oral cavity, often precede OSCCs. Especially, OLs with dysplasia are known to have[r]
Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: A case-control study
Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown.
DEVELOPMENT OF A FLUORESCENCE–BASED MULTIPLEX GENOTYPING METHOD FOR SIMULTANEOUS DETERMINATION OF HUMAN PAPILLOMAVIRUS INFECTIONS AND VIRAL LOADS
Persistent high-risk human papillomavirus (HPV) infection is correlated with an increased risk of developing intraepithelial lesion or malignancy (NILM). The aims of the current study is to establish a method named BioPerfectus Multiplex Real Time (BMRT) HPV assay for simultaneous typing and quantif[r]
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ABERRANT GSTP1 PROMOTER METHYLATION IS ASSOCIATED WITH INCREASED RISK AND ADVANCED STAGE OF BREAST CANCER: A METAANALYSIS OF 19 CASE-CONTROL STUDIES
Glutathione S-transferase P1 (GSTP1) has been reported to function as a tumor suppressor gene in various types of human cancers. Aberrant methylation of tumor-related genes at the promoter regions can inactivate genes, which is important in the carcinogenesis of breast cancer.
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Knowledge, attitudes, and practices toward cervical cancer prevention among women in Kampong Speu Province, Cambodia
In general, the poor uptake of the Pap test could be explained by the fact that people worldwide do not usually undergo health checkups until they experience health problems; therefore, the absence of systematic and active promotion of a screening program in the co[r]
DIETARY CALCIUM INTAKE AND THE RISK OF COLORECTAL CANCER: A CASE CONTROL STUDY
High intake of dietary calcium has been thought to be a protective factor against colorectal cancer. To explore the dose-response relationship in the associations between dietary calcium intake and colorectal cancer risk by cancer location, we conducted a case-control study among Korean population,[r]
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FEASIBILITY AND ACCURACY EVALUATION OF THREE HUMAN PAPILLOMAVIRUS ASSAYS FOR FTA CARD-BASED SAMPLING: A PILOT STUDY IN CERVICAL CANCER SCREENING
Liquid-state specimen carriers are inadequate for sample transportation in large-scale screening projects in low-resource settings, which necessitates the exploration of novel non-hazardous solid-state alternatives. Studies investigating the feasibility and accuracy of a solid-state human papillomav[r]
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TÀI LIỆU PREVENTING CERVICAL CANCER: UNPRECEDENTED OPPORTUNITIES FOR IMPROVING WOMEN’S HEALTH DOCX
along with Pap screening. VIA involves applying 3% to 5% acetic acid (vinegar) to the cervix using a spray or a cotton swab and observing the cervix with the naked eye aer one minute. If charac-teristic, well-dened aceto-white areas are seen adjacent to the trans[r]
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10A CASESTUDY IN IVF PATERNALISM AND AUTONOMYIN A ‘HIGHRISK’ PREGNANCY
10A case-study in IVF: paternalism and autonomyin a ‘high-risk’ pregnancyGillian M. LockwoodMidland Fertility Services, Aldridge, UKIntroductionRenal transplantation, the treatment of choice for patients with end-stagerenal failure, can correct[r]
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RELEVANCE OF MIR-21 IN REGULATION OF TUMOR SUPPRESSOR GENE PTEN IN HUMAN CERVICAL CANCER CELLS
Expression of the microRNA miR-21 has been found to be altered in almost all types of cancers and it has been classified as an oncogenic microRNA or oncomir. Due to the critical functions of its target proteins in various signaling pathways, miR-21 is an attractive target for genetic and pharmacolog[r]
BÁO CÁO HÓA HỌC: " CHARACTERIZATION OF NEUTRALIZING EPITOPES WITHIN THE MAJOR CAPSID PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 33" POT
AbstractBackground: Infections with papillomaviruses induce type-specific immune responses, mainlydirected against the major capsid protein, L1. Based on the propensity of the L1 protein to self-assemble into virus-like particles (VLPs), type-specific vaccines have already been developed. Ino[r]
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The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation
High-risk human papillomaviruses (HPVs) are strongly associated with the development of some malignancies. The E6 and E7 viral oncoproteins are the primary proteins responsible for cell homeostasis alteration and immortalization.