FLUORESCENT CXCR4 TARGETING PEPTIDE AS ALTERNATIVE FOR ANTIBODY STAINING IN EWING SARCOMA
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "Fluorescent CXCR4 targeting peptide as alternative for antibody staining in Ewing sarcoma":
PHASE II STUDY OF OLAPARIB IN PATIENTS WITH REFRACTORY EWING SARCOMA FOLLOWING FAILURE OF STANDARD CHEMOTHERAPY
Preclinical studies have documented antitumor activity of PARP inhibition both in vitro and in vivo, against Ewing sarcoma cells. This study aimed to translate that observation into a clinical trial to assess the efficacy and tolerability of olaparib, a PARP inhibitor, in patients with advanced Ewin[r]
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BÁO CÁO KHOA HỌC: AFFINITY PURIFICATION-MASS SPECTROMETRY POWERFUL TOOLS FOR THE CHARACTERIZATION OF PROTEIN COMPLEXES PPT
of synaptic plasticity by binding to the adaptor proteinPSD95. This protein contains several PDZ domains oneof which binds to the few most C-terminal amino acidsof the NMDA receptor. This particular feature wasexploited for the retrieval of a PSD95-containing complexby immobilizing a hexapept[r]
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BÁO CÁO KHÓA HỌC DIFFERENTIAL CARBOHYDRATE EPITOPE RECOGNITION OF GLOBOTRIAOSYL CERAMIDE BY VEROTOXINS AND A MONOCLONAL ANTIBODY PDF
receptor fatty acid content. Biochemistry 31, 1363–1370.61. Mamelak, D., Mylvaganam, M., Whetstone, H., Hartmann, E.,Lennarz, W., Wyrick, P., Raulston, J., Han, H., Hoffman, P. &Lingwood, C. (2001) Hsp70s contain a specific sulfogalactolipidbinding site. Differential aglycone influence on sulfog[r]
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RANDOMISED CLINICAL TRIAL ASSESSING USE OF AN ANTI-INFLAMMATORY AGENT IN ATTENUATING PERI-OPERATIVE INFLAMMATION IN NONMETASTATIC COLON CANCER – THE S.U.R.G.U.V.A.N.T. TRIAL
Peri-operative inflammation has been extensively highlighted in cancer patients as detrimental. Treatment strategies to improve survival for cancer patients through targeting peri-operative inflammation have yet to be devised.
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TÀI LIỆU BÁO CÁO KHOA HỌC THE ALZHEIMER B PEPTIDE SHOWS TEMPERATURE DEPENDENT TRANSITIONS BETWEEN LEFT HANDED 31 HELIX B STRAND AND RANDOM COIL SECONDARY STRUCTURES DOC
CD experiments have led to estimations of the propen-sity of the amino acids for the PII-helix [14]. Usingthese results to predict the secondary structure of theAb-peptide shows that the PII content of the fulllength peptide should be % 40% at low temperatureand predominantly
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Ewing sarcoma of the liver with multilocular cystic mass formation: A case report
Case presentation: A 27-year-old Japanese woman was admitted with sudden onset right upper abdominal pain. Clinical examination revealed a multilocular cystic mass consisting of thickened, irregular septa and nodal walls in the right hepatic lobe. Ultrasound-guided aspiration biopsy of the li[r]
A FIRST-IN-HUMAN STUDY INVESTIGATING BIODISTRIBUTION, SAFETY AND RECOMMENDED DOSE OF A NEW RADIOLABELED MAB TARGETING FZD10 IN METASTATIC SYNOVIAL SARCOMA PATIENTS
Synovial Sarcomas (SS) are rare tumors occurring predominantly in adolescent and young adults with a dismal prognosis in advanced phases. We report a first-in-human phase I of monoclonal antibody (OTSA-101) targeting FZD10, overexpressed in most SS but not present in normal tissues, labelled with ra[r]
Radiofrequency ablation for liver metastases in patients with gastric cancer as an alternative to hepatic resection
The purpose of this retrospective study was to determine whether RFA could provide an alternative treatment modality for selected patients who are not candidates for hepatic resection.
Detection of bovine Herpesvirus-1 infection in bovine clinical samples by direct fluorescent antibody test
Detection of viral antigen by direct fluorescent antibody test (FAT) from clinical samples collected from cattle and buffaloes of Navsari, Surat and Valsad Districts of Southern Gujarat were carried out. Out of a total of 116 clinical samples (44-cattle, 72-buffaloes) tested, fluorescence was observ[r]
BÀI GIẢNG XÉT NGHIỆM VÀ CHẨN ĐOÁN BỆNH GIANG MAI PART 5 PPSX
Test đặc hiệuNguyên lý Xác định kháng thể Kháng nguyên là T. pallidumBao gồm TPHA, TPPA, FTA-ABS, EIA FTA-ABS: Fluorescent Treponemal Antibody absorption TPHA: Treponema pallidum haemagglutination assay TPPA: Treponemal Pallidum Particle Agglutination EIA: Enzyme immunoassayFTA[r]
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A STUDY OF DOCETAXEL AND IRINOTECAN IN CHILDREN AND YOUNG ADULTS WITH RECURRENT OR REFRACTORY EWING SARCOMA FAMILY OF TUMORS
Patients with Ewing sarcoma family of tumors (ESFT) who are resistant even to salvage chemotherapy, have dismal prognoses and few therapeutic options. Because the docetaxel/irinotecan (DI) combination has not been previously evaluated in ESFT, we prospectively evaluated its use in patients with recu[r]
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BÁO CÁO HÓA HỌC: " DESIGNED HYBRID TPR PEPTIDE TARGETING HSP90 AS A NOVEL ANTICANCER AGENT" DOCX
Department of Pharmacoepidemiology, Graduate School of Medicine andPublic Health, Kyoto University, Yoshida Konoecho, Sakyo-ku, Kyoto, 606-8501, JapanHoribe et al. Journal of Translational Medicine 2011, 9:8http://www.translational-medicine.com/content/9/1/8© 2011 Horibe et al; licensee BioMed Centr[r]
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BÁO CÁO HÓA HỌC TARGETING CEA IN PANCREAS CANCER XENOGRAFTS WITH A MUTATED SCFV FC ANTIBODY FRAGMENT PPTX
105 kDaFigure 1 A chimeric intact antibody and single-chain Fv-Fc (scFv-Fc) fragment. (a) Schematic representation of a chimeric intact antibodyand single-chain Fv-Fc (scFv-Fc) fragment. The table below the figure indicates the molecular weight and half-life of the antibodies. Also asshown, m[r]
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BIOLUMINESCENCE RECENT ADVANCES IN OCEANIC MEASUREMENTS AND LABORATORY APPLICATIONS PART 5 PPT
Bioluminescent Proteins: High Sensitive Optical Reporters for Imaging Protein-Protein Interactions and Protein Foldings in Living Animals 61 chamber, allowing for quantitative analysis of the data. The method of imaging bioluminescence sources in living subjects with a C[r]
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INTERLEUKIN 8 IS A BIOMARKER OF TELOMERASE INHIBITION IN CANCER CELLS
Telomerase activity is required for both initiation and maintenance of tumorigenesis and over 90% cancers overexpress telomerase. Therefore, telomerase targeting has emerged as a potential strategy for cancer treatment.
Extraction and purification of recombinant single chain antibody recognizing blood type a antigen
Denaturing purification of recombinant antiA-scFv
The inclusion bodies of recombinant antiA-scFv in 50 ml cell lysate were pelleted by centrifugation. The pelleted protein was solubilized in 15 ml of denaturing buffer, 6 M Guanidine-HCl. Residual insoluble mat[r]
The inclusion bodies of recombinant antiA-scFv in 50 ml cell lysate were pelleted by centrifugation. The pelleted protein was solubilized in 15 ml of denaturing buffer, 6 M Guanidine-HCl. Residual insoluble mat[r]
BÁO CÁO KHOA HỌC: IDENTIFICATION OF PREFERRED SUBSTRATE SEQUENCES FOR TRANSGLUTAMINASE 1 – DEVELOPMENT OF A NOVEL PEPTIDE THAT CAN EFFICIENTLY DETECT CROSS-LINKING ENZYME ACTIVITY IN THE SKIN POT
lope formation in stratified squamous epithelia. This enzyme catalyzesthe cross-linking of glutamine and lysine residues in structural proteinsin differentiating keratinocytes. To gain insight into the preferredsubstrate structure of TGase 1, we used a phage-displayed randompeptide libr[r]
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RETROSPECTIVE STUDY OF RAS/PIK3CA/BRAF TUMOR MUTATIONS AS PREDICTORS OF RESPONSE TO FIRST-LINE CHEMOTHERAPY WITH BEVACIZUMAB IN METASTATIC COLORECTAL CANCER PATIENTS
After analysis of minor RAS mutations (KRAS exon 3, 4/NRAS) in the FIRE-3 and PRIME studies, an expanded range of RAS mutations were established as a negative predictive marker for the efficacy of anti-EGFR antibody treatment. BRAF and PIK3CA mutations may be candidate biomarkers for anti-EGFR targe[r]
SENSITIVITY COMPARISON OF IMMUNO-HISTOCHEMICAL AND HISTOPATHOLOGICAL APPROACHES FOR DIAGNOSIS OF RABIES IN ANIMALS
To study the approach of immunohistochemistry (IHC) in comparison with study of pathomorphological alterations, for diagnosis of rabies, 50 brain samples from different animals like dog, cattle, buffalo and mongoose suspected for rabies were collected at post mortem hall. Out of the 50 animal brain[r]
MOLECULAR STOOL TESTING AS AN ALTERNATIVE FOR SURVEILLANCE COLONOSCOPY: A CROSS-SECTIONAL COHORT STUDY
As in many other European countries, a nationwide screening program for colorectal cancer (CRC) has recently been introduced in the Netherlands. As a side effect, such a screening program will inherently yield an increase in the demand for surveillance after removal of polyps/adenomas or CRC.
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