PROTEOMIC CHARACTERIZATION OF PAIRED NONMALIGNANT AND MALIGNANT AFRICAN-AMERICAN PROSTATE EPITHELIAL CELL LINES DISTINGUISHES THEM BY STRUCTURAL PROTEINS
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "Proteomic characterization of paired nonmalignant and malignant African-American prostate epithelial...":
CPA-7 INFLUENCES IMMUNE PROFILE AND ELICITS ANTI-PROSTATE CANCER EFFECTS BY INHIBITING ACTIVATED STAT3
Platinum-based chemotherapy is emerging as the first line of treatment for castration resistant prostate cancer. Among the family of platinum (IV)-based compounds, a member known as CPA-7 inhibits the growth of multiple cancer cell lines. However, how and to what extent CPA-7 elicits its anti-prosta[r]
S6KS ISOFORMS CONTRIBUTE TO VIABILITY, MIGRATION, DOCETAXEL RESISTANCE AND TUMOR FORMATION OF PROSTATE CANCER CELLS
The S6 Kinase (S6K) proteins are some of the main downstream effectors of the mammalian Target Of Rapamycin (mTOR) and act as key regulators of protein synthesis and cell growth. S6K is overexpressed in a variety of human tumors and is correlated to poor prognosis in prostate cancer.
BÁO CÁO HÓA HỌC DEVELOPMENT OF TARGETED THERAPY FOR OVARIAN CANCER MEDIATED BY A PLASMID EXPRESSING DIPHTHERIA TOXIN UNDER THE CONTROL OF H19 REGULATORY SEQUENCES DOC
Discussion
The present work shows the use of the regulatory sequences of the H19 gene for the development of DNA- based therapy for human ovarian cancer related ascites. The successful development of anti-tumor gene therapy depends on the use of a combinatorial a[r]
The present work shows the use of the regulatory sequences of the H19 gene for the development of DNA- based therapy for human ovarian cancer related ascites. The successful development of anti-tumor gene therapy depends on the use of a combinatorial a[r]
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Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling
Coronin proteins are known as regulators of actin-based cellular processes, and some of them are associated with the malignant progression of human cancer. Here, we show that expression of coronin 2A is up-regulated in human colon carcinoma.
BÁO CÁO Y HỌC LOCAL LEPTIN PRODUCTION IN OSTEOARTHRITIS SUBCHONDRAL OSTEOBLASTS MAY BE RESPONSIBLE FOR THEIR ABNORMAL PHENOTYPIC EXPRESSION DOC
A relationship exists between obesity/fat mass and bone mass, while the mechanisms responsible for this are still not fully understood, and OA patients have a better preserved bone mass [5,6], independently of body weight [7], than healthy individuals. High body mass index (BMI)[r]
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CLINICAL OUTCOME OF PATIENTS WITH PANCREATIC METASTASES FROM RENAL CELL CANCER
Renal cell cancer (RCC) is one of the most frequent primary sites for metastatic pancreatic tumors although metastatic tumors are rare among pancreatic malignant tumors. The purpose of this study is to disclose the characterization and treatment outcomes of pancreatic metastases from RCC.
BÁO CÁO KHOA HỌC: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF HUMAN IBA PROTEINS PPT
Unusual dimerization of Iba2
In crystal form Iba2 t , which contains one monomer per asymmetric unit, a homodimer is assembled that contains a central disulfide bridge between Cys35 resi- dues of adjacent molecules related by crystallographic symmetry along a twofold rotation a[r]
In crystal form Iba2 t , which contains one monomer per asymmetric unit, a homodimer is assembled that contains a central disulfide bridge between Cys35 resi- dues of adjacent molecules related by crystallographic symmetry along a twofold rotation a[r]
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Lentiviral vectors mediate long-term and high efficiency transgene expression in HEK 293T cells
Lentiviral vectors have been used successfully to rapidly produce decigram quantities of active recombinant proteins in mammalian cell lines. To optimize the protein production platform, the roles of Ubiquitous Chromatin Opening Element (UCOE), an insulator, and selected promoters were evaluated bas[r]
CISPLATIN-RESISTANT CELLS IN MALIGNANT PLEURAL MESOTHELIOMA CELL LINES SHOW ALDHHIGHCD44+ PHENOTYPE AND SPHERE-FORMING CAPACITY
Conventional chemotherapy in malignant pleural mesothelioma (MPM) has minimal impact on patient survival due to the supposed chemoresistance of cancer stem cells (CSCs). We sought to identify a sub-population of chemoresistant cells by using putative CSC markers, aldehyde dehydrogenase (ALDH) and CD[r]
NOVEL C-MET INHIBITOR SUPPRESSES THE GROWTH OF C-MET-ADDICTED GASTRIC CANCER CELLS
KRC-00509 and KRC-00715 were selected as excellent c-Met inhibitors through biochemical assay, and exhibited to be exclusively selective to c-Met by kinase panel assay. Cytotoxic assays using 18 gastric cancer cell lines showed our c-Met inhibitors suppressed specifically the growth of c-Met overexp[r]
Estimating statistical significance of local protein profile-profile alignments
Alignment of sequence families described by profiles provides a sensitive means for establishing homology between proteins and is important in protein evolutionary, structural, and functional studies.
RECAPITULATING EPITHELIAL TUMOR MICROENVIRONMENT IN VITRO USING THREE DIMENSIONAL TRI-CULTURE OF HUMAN EPITHELIAL, ENDOTHELIAL, AND MESENCHYMAL CELLS
Results and discussion Characterization of STEMs Since epithelial tumors are heterogeneous with respect to their cell population and also comprise mesenchymal cells, endothelial cell, im[r]
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BÁO CÁO KHOA HỌC KINETIC CHARACTERIZATION STRUCTURE MODELLING STUDIES AND CRYSTALLIZATION OF TRYPANOSOMA BRUCEI ENOLASE DOCX
With the benefit of the model, steric and chemical differences between trypanosomal and mammalian enolases near the catalytic site, which might facilitate the design of species-specific inhibitors, were sought. The nearest atypical residue to the catalytic site is Lys155, w[r]
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BÀI GIẢNG QUY ĐỊNH PHÁP LUẬT VỀ GIẢI QUYẾT TRANH CHẤP KHIẾU NẠI TỔ CHỨC BTT TRONG LĨNH VỰC CHỨNG KHOÁN VÀ THỊ TRƯỜNG CHỨNG KHOÁN
Cell Cycle Analysis
Cells were seeded in 96-well plates in the recommended growth media and incubated at 37°C in 5% CO2 over- night. The following day, three fold serial dilutions from 556 nM to 7 nM of GSK1070916 were added and the plates incubated for 24, 48 and
Cells were seeded in 96-well plates in the recommended growth media and incubated at 37°C in 5% CO2 over- night. The following day, three fold serial dilutions from 556 nM to 7 nM of GSK1070916 were added and the plates incubated for 24, 48 and
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A small multigene hydroxyproline-Ogalactosyltransferase family functions in arabinogalactan-protein glycosylation, growth and development in Arabidopsis
Arabinogalactan-proteins (AGPs) are ubiquitous components of cell walls throughout the plant kingdom and are extensively post translationally modified by conversion of proline to hydroxyproline (Hyp) and by addition of arabinogalactan polysaccharides (AG) to Hyp residues.
High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor
Epidermal growth factor (EGF) receptors contribute to the development of malignant glioma. Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to the activity of the unfolded protein response (UPR) sensor IRE1α. We also examined EREG sta[r]
CHARACTERIZATION OF THE PUTATIVE LIPASE MOTIF OF AGROBACTERIUM VIRULENCE PROTEIN VIRJ
Till now, little is known about the function of AcvB and VirJ. Previous studies showed that acvB mutant blocked the T-DNA transfer at some step other than vir gene induction, and AcvB is not required for the transfer of the conjugal DNA or for the viability in the[r]
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CAISMOV24, A NEW HUMAN LOW-GRADE SEROUS OVARIAN CARCINOMA CELL LINE
The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma.
Metformin inhibits epithelial to mesenchymal transition of keloid fibroblasts via the HIF-1α/PKM2signaling pathway
Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cells lose cell-cell contacts and acquire expression of mesenchymal components and manifest a migratory phenotype. Recent studies indicated that EMT is involved in the development of keloids.
Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathway
Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) has been found to promote BC cell proliferation and invasion by regulating the microRNA (miR)-101/zinc-finger enhancer binding axis i[r]