EFFECTS OF THE LYSOSOMAL DESTABILIZING DRUG SIRAMESINE ON GLIOBLASTOMA IN VITRO AND IN VIVO

BioMed CentralPage 1 of 9(page number not for citation purposes)Journal of NeuroinflammationOpen AccessResearchInhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9Timothy J Cunningham*, Jaquie Maciejewski and Lihua YaoAddr[r]

Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent inducer of autophagy and its expression results in necroptotic cell death in vitro and tumor dormancy in vivo.

the inhibitor studies, 20 lm IC-261, a CKIe ⁄ d-selective inhib-itor [19], was added for the final hour of labeling.Xenopus embryo injections and analysis of phenotypeswere performed as previously described [14]. MTXDshcDNA was obtained from S Sokol (Department o[r]

DNA species were incubated with TF-SPO11-1 underthese and modified conditions (Fig. S1). We did notdetect any activity for covalent attachment to theDNA-binding surface of Arabidopsis SPO11 protein Y. Shingu et al.2364 FEBS Journal 277 (2010) 2360–2374 ª 2010 The Authors Journal[r]

97(23):12846-51.16. Aboody KS, Najbauer J, Danks MK: Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther 2008, 15(10):739-52.17. Arbab AS, Pandit SD, Anderson SA, Yocum GT, Bur M, Frenkel V, Khuu HM, Read EJ, Frank JA: Magnetic resonance imaging and confocal micro[r]

failure or cancer. These decisions illustrate the continuing highly personal nature of the relationship between the prescriber and the patient. Some adverse effects are so common and so readily associated with drug therapy that they are[r]

The netrin-1 receptor UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. However, the functional significance of UNC5B overexpression in bladder cancer remains unclear. In this study, we investigated the role of UNC5B in bladder cancer in vitro and in vi[r]

than systemic administration. For example, initial clini-cal trials for RNAi-based treatment of age-related mac-ular degeneration have exclusively used local injectionsof siRNA directly into the eye [10]. Other promisinglocal routes include intranasal siRNA administrationfor pulmonary[r]

Internet's ability to give people world wide access to anything. This is justone more example of electronic information flowing into a country where itnot allowed. Because of the ease at which banned books can now beobtained anywhere, the future of what we now know[r]

alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science 2002,296:151-155.14.Aumailley M, Gurrath M, Muller G, Calvete J, Timpl R, Kessler H: Arg-Gly-Aspconstrained within cyclic pentapeptides. Strong and selective inhibitorsof cell adhesion to vitronectin and laminin fragmen[r]

not shown), this is unlikely to contribute significantlyto the increased kinase activity of the IR, as Grb7 isboth less potent and less efficient than Grb14 in its abil-ity to inhibit in vitro activation of IR tyrosine kinase[7]. At the pr[r]

GAG TGC AGT GTG AAA ACG GAC TAA TAC AGTG-3¢) forward and NR (5¢-CAT GCC ATG GTG GCGSp regulation of the AbH-J-J locus P1 promoter G. Feriotto et al.4486 FEBS Journal 274 (2007) 4476–4490 ª 2007 The Authors Journal compilation ª 2007 FEBSGAC CTC CTT CAG TGC-3¢) reverse pri[r]

operators and farmers. Am J Respir Crit Care Med 1995, 151:47-53.23. Kennedy SM, Christiani DC, Eisen EA, Wegman DH, Greaves IA,Olenchock SA, Ye TT, Lu PL: Cotton dust and endotoxin expo-sure-response relationships in cotton textile workers. Am RevRespir Dis 1987, 135:194-200.24[r]

Former studies already revealed the anti-neoplastic properties of the anti-infective agent Taurolidine (TRD) against many tumor species in vitro and in vivo. Its anti-proliferative and cell death inducing capacity is largely due to its main derivative Taurultam (TRLT).

Chromosome 7 open reading frame 24 (C7orf24) was originally identified as a highly expressed protein in various types of cancer, and later shown to be a γ-glutamylcyclotransferase (GGCT). GGCT depletion in cancer cells has anti-proliferative effects in vitro and in vivo, and it is therefore consider[r]

22. Ryan KE, Casey SM, Canty MJ, Crowe MA, Martin F, Evans ACO: Aktand Erk signal transduction pathways are early markers ofdifferentiation in dominant and subordinate ovarian folliclesin cattle. Reproduction 2007, 133:617-626.23. Glister C, Tannetta DS, Groome NP, Knight PG: Interacti[r]

FEDORAK R.N., MADSEN K.L.: Probiotics and prebiotics in gastrointestinal disorders. Curr.Opin.Gastroenterol. 20, 146–155 (2004). ISOLAURI E., ARVOLA T., SUTAS Y., MOILANEN E., SALMINEN S.: Probiotics in the management of atopic eczema. Clin.Exp.Allergy 30, 1604–161[r]

Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, ca[r]

Cholangiocarcinoma is characterized by late diagnosis and a poor survival rate. MicroRNAs have been involved in the pathogenesis of different cancer types, including cholangiocarcinoma. Our aim was to identify novel microRNAs regulating cholangiocarcinoma cell growth in vitro and in vivo.

inger H, Burton DR: Anti-human immunodeficiency virus type1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly fewcrucial residues in the membrane-proximal external regionof glycoprotein gp41 to neutralize HIV-1. J Virol 2005,79:1252-1261.25. Cardoso RM, Zwick MB, Stanfield RL[r]