HIGH EXPRESSION OF NQO1 IS ASSOCIATED WITH POOR PROGNOSIS IN SEROUS OVARIAN CARCINOMA

benign ovarian tumors in fresh tissues. These results indi- cate that NQO1 may be a useful biomarker for poor prog- nosis in patients with ovarian carcinoma.
Previously, we have shown that high expression of NQO1 protein was str[r]

Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated.

Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis in several malignant tumors. The aim of this study was to evaluate the expression and prognostic value of Talin-1 in nasopharyngeal carcinoma (NPC).

2007, 67:8699-707.38. Nam EJ, Yoon H, Kim SW, Kim H, Kim YT, Kim JH, Kim JW, Kim S:MicroRNA expression profiles in serous ovarian carcinoma.Clin Cancer Res 2008, 14(9):2690-5.39. Taylor DD, Gercel-Taylor C: MicroRNA signatures of tumour-derived exosomes as d[r]

in our TMA immunoscreen will help us to identify novelJournal of Translational Medicine 2009, 7:8 http://www.translational-medicine.com/content/7/1/8Page 11 of 15(page number not for citation purposes)TRIP-Br2 expression is dysregulated in many human[r]

high-throughput molecular profiling of tumor specimens. Nat Med 1998, 4:844-847.15. Kobel M, Kalloger SE, Boyd N, McKinney S, Mehl E, Palmer C, Leung S, Bowen NJ, Ionescu DN, Rajput A, et al.: Ovarian carcinoma subtypes are different diseases implications for biomarker st[r]

Epithelial ovarian cancer (EOC) is the most common cause of gynecological malignancy-related mortality. Ovarian clear cell carcinoma (CCC) has unique clinical characteristics and behaviors that differ from other histological types of EOC, including a frequent association with endometriosis and a hig[r]

Hepatocellular carcinoma has a dismal prognosis due to recurrence rates of up to 70% after curative resection. Early recurrence is driven by synchronous microscopic intrahepatic metastases. The predictive value of histological parameters is discussed controversially and adjuvant therapy is not estab[r]

EMT. Instead, our cells expressing SOX2 showed a lower proliferative rate, were less adherent and displayed a more spheroid growth pattern compared to wild type cells. These are all characteristics of CSCs. CSCs possess stem cell-like features, like the ability of self-renewal and mu[r]

Mantle Cell Lymphoma (MCL) is often associated with progression, temporary response to therapy and a high relapse rate over time resulting in a poor long-term prognosis. Because MCL is classified as an incurable disease, therapeutic resistance is of great interest.

The function of hornerin (HRNR), a member of the S100 protein family, is poorly clarified in the development of human tumors. The role of HRNR in hepatocellular carcinoma (HCC) progression is investigated in the study.

Ovarian low-grade serous carcinoma (LGSC) has fewer mutations than ovarian high-grade serous carcinoma (HGSC) and a less aggressive clinical course. However, an overwhelming majority of LGSC patients do not respond to conventional chemotherapy resulting in a poor long-term prognosis comparable to wo[r]

This study aims to evaluate the impact of colony stimulating factor-1 (CSF-1) expression on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. Methods: We retrospectively enrolled 267 patients (195 in the training cohort and 72 in the validation cohor[r]

Angiogenesis is essential for tumor growth. Hepatocellular carcinoma (HCC) is characterized by hypervascularity; high levels of angiogenesis are associated with poor prognosis and a highly invasive phenotype in HCC. Up-regulated gene-4 (URG4), also known as upregulator of cell proliferation (URGCP),[r]

Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with cancer.

Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to evaluate whether 5-aza-2-deoxycytidine (5-aza-2-dC) can reverse methylation of the HIN-1 gene t[r]

Biochem Biophys Res Commun 1997, 236:804-807.14. Ponten F, Jirstrom K, Uhlen M: The Human Protein Atlas–a tool forpathology. J Pathol 2008, 216:387-393.15. Bjorling E, Lindskog C, Oksvold P, Linne J, Kampf C, Hober S, Uhlen M,Ponten F: A web-based tool for in silico biomarker discovery based[r]

The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated myofibroblasts (CAFs) are present. Recent studies showed promising results after liver transp[r]

Hyaluronan metabolism in cutaneous melanoma seems to differ from the main adenocarcinomas, such as the breast carcinoma. Increased stromal hyaluronan content has been associated with poor survival and tumor differ- entiation in various human adenocarcinomas,[r]

Cdk1 (cyclin-dependent kinase 1) is critical regulator of the G2-M checkpoint. Cyclin-dependent kinase pathways are considered possible targets for cancer treatment; however, the prognostic role of Cdk1 in colorectal cancer is still controversial. Therefore, we attempted to determine the impact of C[r]