UPREGULATION OF THE PROTO-ONCOGENE BMI-1 PREDICTS A POOR PROGNOSIS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA

Discussion
New biomarkers could be helpful in predicting treatment outcomes earlier and more precisely, which is of great interest to physicians and researchers in the field. This re- port describes for the first time that the proto-oncogene Bmi<[r]

The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse effects of chemotherapy

This study aims at determining the health-related quality of life (HRQOL) of children with acute lymphoblastic leukemia (ALL) after the induction therapy, assessing the agreement between child self-reports and family proxy-reports HRQOL, and determining the factors related to this agreement, especia[r]

evant areas during cancer treatment such as pain, nausea,treatment and procedural anxiety, worry, cognitive prob-lems, perceived physical appearance and communication.Items are scored using a four point Likert scale and reflecton the past week. Higher scores indicate better QoL. Thesca[r]

This meta-analysis included 11 studies with 997 patients, and the systematically evaluated outcomes demonstrated the high level of NPM was significantly
correlated to poor overall survival in various solid tumors. It suggested that NPM overexpression was a[r]

groups: standard risk (SR) and high risk (HR). Both pro-tocols consist of an induction, consolidation, re-induc-Health and Quality of Life Outcomes 2008, 6:96 http://www.hqlo.com/content/6/1/96Page 3 of 8(page number not for citation purposes)tion (only for HR) and mainte[r]

L1 cell adhesion molecule (L1CAM) overexpression has been reported to be strongly associated with poor prognosis in early stage endometrial cancer (EC). We aimed at the validation of L1CAM as a marker of poor prognosis in an independent study population.

Background
Pilocytic astrocytoma (PA) is the most common type of brain tumor in the pediatric population, comprising ap- proximately 25 % of all primary tumors, with the most fre- quent occurrence taking place between 5 – 10 years of age. F[r]

không thể có hai trường hợp ung thư nào giống hệt nhau về mặt di truyền cho dù đều thuộc cùng loại bệnh. Tuy nhiên, nghiên cứu cho thấy có một nhóm gen gây ra các rối loạn hoạt động tế bào trong ung thư. Các gen điều hòa bình thường có thể phân chia thành hai nhóm theo tác dụng của sản phẩm của chún[r]

The simultaneous Occurrence of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) has been rarely reported. Most of these cases have been occurring more frequently as a secondary event in patients receiving chemotherapeutic agents for CLL.

Email: Mei N Sitaresmi* - msitaresmi@yahoo.com; Saskia Mostert - smostert@vumc.nl; Chad M Gundy - c.gundy@nki.nl; Sutaryo - sutaryo@indosat.net.id; Anjo JP Veerman - ajp.veerman@vumc.nl* Corresponding author AbstractBackground: Most studies on Health-related Quality of Life (HRQOL) in[r]

The association between body mass index (BMI) at the time of breast cancer diagnosis and the prognosis of breast cancer patients remains controversial. Furthermore, the association between BMI and prognosis with respect to different breast cancer subtypes is not clearly defined.

LeukemiaIncidence of leukemia around the world was believed to have experienced an increasewhen the new technology was introduced in the late 1970s which helped indiagnosing cancer effectively. Earlier report by SEER found a short-term increase ofleuk[r]

months will have evidence of reflux. Whether true dis-ease, in one form or another, exists deserves furtherstudy. However, approximately 33% will seek medicalattention and the regurgitation symptoms in most(&gt;70%) of these children will resolve with minimalin[r]

Differentiation syndrome (DS) is the main life-threatening adverse event that occurs in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA). Cytokine imbalances have been reported to play role during the developing of acute promyelocytic leukemia differentiation s[r]

The study was reviewed and approved by the Hartfordhospital IRB. We included patients with spontaneousICH from Jan 2005 to April 2010. We excluded* Correspondence: lmccullough@uchc.edu1Department of Neurology, University of Connecticut, 263 FarmingtonAvenue, Farmin[r]

5. Bostrom BC, Sensel MR, Sather HN, Gaynon PS, La MK, Johnston K,Erdmann GR, Gold S, Heerema NA, Hutchinson RJ, Provisor AJ, TriggME: Dexamethasone versus prednisone and daily oral versusweekly intravenous mercaptopurine for patients with stand-ard-risk acute lymphoblastic leukemia[r]

colony-stimulating factor (G-CSF) receptor and, often, neutrophil elastase that may evolve into AML. Myeloproliferative syndromes may also evolve into AML (Chap. 103). Germ-line mutations of CCAAT/enhancer-binding protein α (C/EBP α), runt-related transcription factor 1 (RUNX1), and tu[r]

Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML).

Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, which recognizes the acetylated lysine residues, has been shown to induce cell cycle arrest in[r]