A database consisting of 23 tripeptides was used to study the quantitative relationships between electric surface potential descriptors and antioxidant activity QESARs. The important structural descriptors SaaNH_acnt, SsOH_acnt, SaaN, SaaN_acnt, SsssCH, SaaaC, SsNH3p, SdO, SdO_acnt were selected for[r]
and data handling systems. Because separation and detec- tion occur at or slightly above ambient temperature, this method is ideally suited for compounds of limited thermal stability. The ability to inject large sample amounts (up to 1–2 ml per injection) makes HPLC a very sensitive analysis techn[r]
and the United Kingdom Prospective Diabetes Study 5 confirmed the value of glycemic control in the delay or prevention of complications of diabetes. The limiting pharmacokinetic and pharmacodynamic features of standard insulins, which frequently lead to hypogly- cemia as glycosylate[r]
Antimalarial agents are used as therapy for several skin diseases, including the skin manifestations of lupus and polymorphous light eruption, but they can also induce cutaneous reactions. The most frequent is pruritus, which occurs in up to 50% of African patients r[r]
The new optical design of the Agilent 1100 Series fluores- cence detector is illustrated in figure 62. A Xenon flash lamp is used to offer the highest light intensities for exci- tation in the UV range. The flash lamp ignites only for microseconds to provide light energy. Each flash causes fluoresce[r]
79 convert the carbodiimide into guanidine prior to cleavage. This was achieved by the addition of (2-methyl)propylamine to the carbodiimide to give guanidine. Subsequently the guanidine was cleaved from the resin and subjected to LCMS analysis. The use of methanol-water mixture as m[r]
These ownership interests can be very lucrative because they allow managers to share in the profits of possibly successful television programs and motion pictures. 40 Although some managers make a living by charging commissions, they do not face agent-like conflicts of interest. In the least, the[r]
conditions. Ga-PP is very toxic to Gram-negative bacteria (MIC < 2 l m ) and some Gram-positive bacte- ria such as Staphylococcus species (MIC < 3 l m ) [11]. Ga-PP seems to be transported into Gram-negative bacteria via haem uptake systems [11]. The toxicity of Ga-PP has been suggest[r]
The Kaleckian conception was developed especially by Joan Robinson’s in some articles (particularly ‘Normal Prices’ and ‘A Model of Accumu- lation’) collected together in Essays in the Theory of Economic Growth (1962). In the models of growth with unemployment and under-utilization of plant, the k[r]
Apart from reasons to develop and/or offer agents, there are also good reasons - for some - not to do so. Usage of the three layer model, and of agents, leads to a very transparent market, as users - by means of the middle layer and/or agents, can get a detailed overvie[r]
We see several exciting research problems that are addressed by our recent work in this area: one problem is that global configurations of elements are dependent on local interaction, and simple processors inside each element will not suffice to calculate and control the overall configuration. That[r]
Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as dis[r]
Synthesis of tubulysin analogues from tripeptide 89 _ Coupling reaction of trifluoroacetic salt of 89 with 5-methylpyrazin-1-carboxylic and isoquinoline -1-carboxylic acid using HATU in [r]
Mechanically recovered meat Meat recovered from bone using separation machinery. Mechanical recovery increases the efficiency of separation and thereby allows the recovery of extra meat per carcass; it is also less time consuming than hand boning of meat. In many systems, meat and bone are fo[r]
in animals, phosphinothricins as herbicides, spinosyns as insecticides, and cyclosporin as an immunosuppressant. Cyclosporin A virtually revolutionized the practice of organ transplantation in medicine. Broad screening allowed the polyether monensin to take o[r]
Arsenic trioxide produces meaningful responses in up to 85% of patients refractory to tretinoin. The use of arsenic trioxide is being explored as part of initial treatment in clinical trials of APL. Additionally, studies combining arsenic trioxide with tretinoin in t[r]
Neuropeptides (protein molecules) are synthesised in the neurons, helps to communicate the impulse from the stimulant to the receptor. Neuropeptides are responsible for regulating a various physiological functions including development, metabolism, water and ion homeostasis, and as neuromodulators i[r]
Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents Discovery an[r]
Vegetable oils as clearing agents 2016 achievements in the life sciences Vegetable oils as clearing agents 2016 achievements in the life sciences Vegetable oils as clearing agents 2016 achievements in the life sciences Vegetable oils as clearing agents 2016 achievements in the life sciences Vegetabl[r]