FABRICATION OF ELECTROSPUN NANOFIBRES OF BCS II DRUG FOR ENHANCED DISSOLUTION AND PERMEATION ACROSS SKIN

The objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized by low solubility and high permeability, using carvedilol, a weak base with a pKa value of 7.8, as a model drug. A s[r]

Certain drugs, such as NSAIDs, ACE inhibitors, angiotensin II antagonists, and radiographic dyes, may induce urticarial reactions, angioedema, and anaphylaxis in the absence of drug-specific antibody. Although ACE inhibitors, aspirin, penicillin, [r]

The purpose of this study is to i) fabricate a biodegradable nanoparticle formulation of Ketoprofen, ii) evaluate its characteristics, iii) investigate its in vitro dissolution and in vivo pharmaceutical property. The nanoparticle formulation was prepared by spray drying method using Eudragit L100 a[r]

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioav[r]

Abstract Syngas and hydrogen production by methane reforming of a biogas (CH4CO2 = 2.85) using
carbon dioxide was evaluated in a fixed bed reactor with a PdAg membrane in the presence of a nickel
catalyst (Ni 3.31% weight)γAl2O3) at 773 K, 823 K, and 873 K and 1.01×105 Pa. Operation with hydrogen
p[r]

developed to evaluate the material compositions at specific location. However, the algorithm was computationally intensive and required large memory for handling complex objects. Shin and Dutta (2001) proposed a constructive representation scheme for FGM objects. Con[r]

Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery. However, the applicability of metabolite-likeness in drug discovery has been largely unexplored.

Our objectives in this study are to: • Investigate the feasibility of using the electrospun TG-NF construct as a cost-effective scaffold for fibroblast integration and proliferation to e[r]

Of the autoimmune diseases associated with diffuse hyperpigmentation,
biliary cirrhosis and scleroderma are the most common, and occasionally both
disorders are seen in the same patient. The skin is dark brown in color, especially in sun-exposed are[r]

Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational methods to accurately and efficiently predict the metabolic decomposition of drug-like mole[r]

Human tumour xenografts in immune compromised mice are widely used as cancer models because they are easy to reproduce and simple to use in a variety of pre-clinical assessments. Developments in nanomedicine have led to the use of tumour xenografts in testing nanoscale delivery devices, such as nano[r]

There are no reports on investigations of the characteristics of adverse drug reaction (ADR) reports for pediatric patients in the Japanese Adverse D.rug Event Report database (JADER) and the utility of database for drug safety surveillance in these patients

(E) shows a TEM micrograph for “ analytically pure ” TiO 2
commercial powder. The particle size is about 10 μ m.
Compared with Kasuga et al. [7] , who have prepared titanium oxide nanotubes with a diameter of ≈ 8 nm and a length of ≈ 100 nm when sol – gel-derived fine[r]

μ g·l -1 , respectively. Conclusions
A simple one-step electroless deposition process has been applied to prepare Ag/GL substrates for arsenate SERS sensing. Monolayer, double-layer, and multilayer AgNPs films with different nanostructural characteristics could be controllably deposi[r]

Changes in skin
Evidence of increasing age includes wrinkles and sagging skin. Aging skin appears thinner, more pale, and clear (translucent). Thus, skin is at higher risk for injury. Large pigmented spots (called age spots, liver spots, or[r]

Viruses of the flaviviridae family are responsible for some of the major infectious viral diseases around the world and there is an urgent need for drug development for these diseases. Most of the virtual screening methods in flaviviral drug discovery suffer from a low hit rate, strain-specific effi[r]

class, since this style information is inherited.
4.3. Mozilla Skins
At an earlier point in Mozilla's history, all interface files -- the XUL, the CSS, and the images -- were stored in directories named after the main Mozilla packages in the application chrome directory. The best way t[r]

nomics of the process (Deshpande, Siva Raman, and Rao 1984; Schell et al. 1988; Wright, Wyman, and Grohmann 1988; Philippidis and Smith 1995). Because several inhibitory compounds are formed during hydrolysis of the raw material, the hydrolytic process has to be[r]

To identify predictive factors of radiation-induced skin toxicity in breast cancer patients by the analysis of dosimetric and clinical factors. In our experience dose inhomogeneity underneath G2 – G3 skin reactions seems to be the most important predictor for acute skin damage and in these patients[r]

In summary, we have described a novel approach to chemical sensors based on aligned ZnO NRAs grown on Pt-coated Si substrates with a top–top electrode configu- ration. The O 2 and NO 2 sensing properties of the fabricated sensor showed both a high sensitivity and an excellent re[r]