A NOVEL SPHEROID-BASED CO-CULTURE MODEL MIMICS LOSS OF KERATINOCYTE DIFFERENTIATION, MELANOMA CELL INVASION, AND DRUG-INDUCED SELECTION OF ABCB5-EXPRESSING CELLS
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell i...":
A novel pancreatic tumour and stellate cell 3D co-culture spheroid model
Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitro 3D assay employing the main constituents of pancreatic ductal adenocarcinoma, namely panc[r]
INHIBITION OF NA+ /K+ -ATPASE INDUCES HYBRID CELL DEATH AND ENHANCED SENSITIVITY TO CHEMOTHERAPY IN HUMAN GLIOBLASTOMA CELLS
Results Ouabain-induced cell volume changes and toxicity in LN229 cells Exposure of glioblastoma LN229 cells to ouabain caused noticeable morphological changes including cell swelling an[r]
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Sodium iodide symporter (NIS) in extrathyroidal malignancies: Focus on breast and urological cancer
NIS and other malignancies
Tumors arising in different non-thyroidal organs, such as esophagus, colon, liver, pancreas, lung, ovary, and skin, showed NIS expression (Table 4), though the transporter was mainly and weakly detected only in the cytoplasm of neoplastic c[r]
Tumors arising in different non-thyroidal organs, such as esophagus, colon, liver, pancreas, lung, ovary, and skin, showed NIS expression (Table 4), though the transporter was mainly and weakly detected only in the cytoplasm of neoplastic c[r]
MESENCHYMAL STEM CELLS ENHANCE THE METASTASIS OF 3D-CULTURED HEPATOCELLULAR CARCINOMA CELLS
9. Zhu W, Xu W, Jiang R, Qian H, Chen M, Hu J, Cao W, Han C, Chen Y. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol. 2006;80:267 – 74.
10. Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hal[r]
10. Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hal[r]
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Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The prese[r]
lncRNA CRNDE promotes the proliferation and metastasis by acting as sponge miR539-5p to regulate POU2F1 expression in HCC
This article focuses on the roles and mechanism of lncRNA CRNDE on the progression of HCC. MTT assay, FCM analysis, Transwell migration and invasion assay were used to detect the effects of lncRNA CRNDE on cell viability, apoptosis, migration and invasion of HCC cells.
CHAPTER 069. TISSUE ENGINEERING (PART 1) DOC
For example, the cell-to-cell interactions and function of endothelial cells in the pulmonary microvasculature are different from those in the blood-brain barrier.
The microenvironment of the cell, including the presen[r]
The microenvironment of the cell, including the presen[r]
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IPILIMUMAB AND IMMUNE-MEDIATED ADVERSE EVENTS: A CASE REPORT OF ANTI-CTLA4 INDUCED ILEITIS
Ipilimumab is a fully human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 , a key negative regulator of T-cell activation approved by the Food and Drug Administration as of March 2011 for the treatment of metastatic melanoma.
HISTONE DEACETYLASE INHIBITORS INDUCE INVASION OF HUMAN MELANOMA CELLS IN VITRO VIA DIFFERENTIAL REGULATION OF N-CADHERIN EXPRESSION AND RHOA ACTIVITY
Therefore, in order to characterize the effect of HDACi on human melanoma cells, we have evaluated the invasive-ness of two human melanoma cell lines A375, derived from a primary tumor, [r]
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Generating in vitro solid tumor models on gelatin-alginate scaffolds
In recent years, three-dimensional (3D) in vitro tumor models have become more common in cancer research across the world. Selecting scaffolds, seeding cells into the scaffolds, and culturing them are pivotal for the morphologies and proliferation of cancer cell lines. Therefore, this experience has[r]
OPTIMISING IN VITRO CULTURE AND AGROBACTERIUM TUMEFACIENS-MEDIATED TRANSFORMATION PROTOCOLS OF TOBACCO BY 2 CELLS
In order to set up a system for production of recombinant proteins using suspension cell culture of Nicotiana tabacum cv. Bright Yellow 2 (BY-2), in vitro culture and genetic transformation protocols of such cells were optimised at the laboratory of Plant Cell Biotechnology, Institute of Biotechnolo[r]
A NUMERICAL STUDY OF FLUID FLOW AND MASS TRANSPORT IN A MICROCHANNEL BIOREACTOR
Figure 6.5 Dimensionless pressure gradients in terms of the roughness size ratio α
at different spacing ratio β in semicircle and triangle rough microchannels
Figure 6.6 Comparison of dimensionless shear stress τ s R , at base in one unit in different rough[r]
at different spacing ratio β in semicircle and triangle rough microchannels
Figure 6.6 Comparison of dimensionless shear stress τ s R , at base in one unit in different rough[r]
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Nhận biết và nuôi cấy đơn dòng tế bào gốc phân lập từ nút phôi của túi phôi chuột
and long term culture of embryonic stem cells derived from inner cell mass of mouse blastocysts (Mus. musculus)[r]
BÁO CÁO SINH HỌC SHRINKAGE CONTROL REGULATION OF INSULIN MEDIATED GROWTH BY FOXO TRANSCRIPTION FACTORS PPT
Insulin signaling regulates growth by controlling both cell size and cell number, and mutations in different compo- nents of this pathway in Drosophila have been shown to cause distinct effects on these parameters. For example, the small flies resulting from muta[r]
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BIO MEMS TECHNOLOGIES AND APPLICATIONS WANG AND SOPER EDS PART 16 PPTX
Pharmaceutical Analysis Using Bio-MEMS 455
(PCR). The resulting DNA related to the disease was detected following electrophoretic separation.
Wang et al. have coupled an enzymatic bioassay with an electrophoretic separation on-chip for the measurement of the renal markers creatine, cre-[r]
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BÁO CÁO KHOA HỌC POTX
Quantum dot labeling
MSCs were labeled with Q-Tracker 605 Cell Labeling kit (Invitrogen, Carlsbad, CA). These QDs, approximately 10–15 nm in diameter, are composed of a cadmium sele- nium core and an inner zinc sulfide shell (CdSe/ZnS). A custom peptide bonded to[r]
MSCs were labeled with Q-Tracker 605 Cell Labeling kit (Invitrogen, Carlsbad, CA). These QDs, approximately 10–15 nm in diameter, are composed of a cadmium sele- nium core and an inner zinc sulfide shell (CdSe/ZnS). A custom peptide bonded to[r]
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BÁO CÁO Y HỌC PREVENTING AUTOIMMUNE ARTHRITIS USING ANTIGEN SPECIFIC IMMATURE DENDRITIC CELLS A NOVEL TOLEROGENIC VACCINE PPTX
In order to determine the possible clinical relevance of such LF-treated DC for inducing antigen-specific tolerance or hyporesponsiveness, we assessed their ability to modulate disease progression in the murine CIA, as an experimental model of RA. CIA mirrors many aspects of<[r]
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Muscle extracellular matrix scaffold is a multipotent environment
The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the hos[r]
Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer
AF-6/afadin plays an important role in the formation of adherence junctions. In breast and colon cancer, loss of AF-6/afadin induces cell migration and cell invasion. We aimed to elucidate the role of AF-6/afadin in human endometrial cancer.
Titanium dioxide nanoparticles as radiosensitisers: An in vitro and phantom-based study
Radiosensitisation caused by titanium dioxide nanoparticles (TiO2-NPs) is investigated using phantoms (PRESAGE® dosimeters) and in vitro using two types of cell lines, cultured human keratinocyte (HaCaT) and prostate cancer (DU145) cells.