2. Epidemiology Dual infection with HBV and HCV is not uncommon in geographic areas where a high endemic level of both infections is reported, such as Southeast-Asia and Mediterranean. In general, the prevalence is around 10-20% in patients with chronic HBV infection (see table1) [1-10[r]
Kevin Robertson5, Robert Paul6, Cecilia Shikuma1, Victor Valcour1 1. Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA; 2. Armed Forces Research Inst. Med. Sciences, Bangkok, Thailand; 3. Phramongkutklao Hosp., Bangkok, Thailand; 4. Royal Thai Army Med. Dep[r]
studies [3, 4] which were anyway published had in fact no power whatever to detect the assumed effect of loratadine, and a larger retrospective case-control study [5] was restricted to relatively severe cases and used retrospective data on drug exposure. The most recent study [1] was based on[r]
resistance to some antibiotics. Indeed, H. pylori strains resistant to clarithromycin and metronidazole have been increasing [11-18]. In the near future, antibiotic resistance will be the utmost impediment in the chemotherapy of H. pylori infection. In addition, new triple therapies occasionally cau[r]
genotypes 2 and 3 and 48 weeks in genotype 1 infection. Hematologic inclusion criteria included ANC > 800 cells/mL, hemoglobin > 10 g/dL and platelets > 35,000/mL. Growth factors were allowed in the management of therapy-induced cytopenias. The investigators estimated tha[r]
and persisted for more than 24 hr. This information provided a novel insight into the mechanisms of action of ethanol (1mM) in human hepatocellular carcinoma cells. Key words: Ethanol, HepG2 cells, protein kinases, signal transduction, transcription factors, gene expression 1. Introduc[r]
past decade. Where on one hand, this treatment has proven its effectiveness in ideal population; it has also identified some special populations by way of poor response or difficulties faced due to co morbid conditions. These special populations include patients with cirrhosis, non responders to pri[r]
duplicate using a highly sensitive, quantitative sandwich enzyme immunoassay technique (Human Adiponectin/Acrp30 Quantikine Immunoassay, R&D Systems, Minneapolis, MN) with CV of 3%. HOMA-IR Whole-body insulin resistance was estimated using the homeostasis model assessment of insulin resistan[r]
FBW7, FBXW7) has recently emerged as a potent new potential tumor suppressor gene [1, 2]. The highly conserved protein consists of an NH2 terminal F-box and seven WD40 repeats in the COOH terminal region and acts as an adaptor protein providing substrate specificity for SCF (Skp–Cullin–F-box)[r]
based regimens were unfavorable, leading to concern for the safety of such an approach. Crippin and colleagues randomized end-stage liver disease patients on the transplant waiting list to three dose regimens: interferon alfa-2b, 1 million units (MU) daily, interferon alfa-2b 3MU t.i.w., and[r]
2005; 352(20):2049–2060. 15. Sarnak MJ, Katz R, Stehman-Breen CO, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005; 142(7):497–505. 16. Mooradian AD. Digitalis. An update of clinical pharmacokinetics, therapeutic monitoring techniques and treat[r]
Key words: phyllodes tumor, liposarcoma, tubular adenoma 1. Introduction Phyllodes tumors are rare entity in the breast. They make up less than 1% of all breast tumors [1]. The majority of these lesions behave in a completely benign fashion in that they do not have metastatic potential[r]
such as poorly controlled hypertension or diabetes, obstructive pulmonary disease, or significant heart disease. Patients with autoimmune hepatitis or other conditions known to be exacerbated by interferon and ribavirin or known to have hypersensitivity to these drugs should not receive treatment. T[r]
24, the likelihood of an SVR is virtually nil and treatment can be stopped or continued with the only aim to slow liver disease progression in patients with a severe prognosis, without any hope to eradicate infection (Figure 1A) [18, 22]. Ongoing trials are studying whether a prolonged antivi[r]
each county. These systems include information on WHO’s Anatomical Therapeutic Chemical (ATC) classification code, the amount of the drug prescribed, the personal identification number, and the date of drug dispension. Since January 1 1989 all data from North Jutland County have been stored i[r]
acute HCV infection persists and 4% to 20% of patients with chronic hepatitis C will develop liver cirrhosis within 20 years. In patients with liver cirrhosis, the risk to develop HCC is 1-5% per year. Current standard therapy is the combination of pegylated interferon-α (PEG-IFN-α) and ribav[r]
among natural weight loss supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbo-hydrate-derived calories and/or by providing resistant starches to the lower gastro[r]