THE EVIDENCE BASE FOR CIRCULATING TUMOUR DNA BLOOD-BASED BIOMARKERS FOR THE EARLY DETECTION OF CANCER: A SYSTEMATIC MAPPING REVIEW

development of rapid and reliable detection for mad cow disease, aproblem which has been waiting for a right solution.6. ConclusionThe development of ideal biosensors which are fast, easy to use,specific, and inexpensive, doubtlessly, requires the sign[r]

new technologies have been developed recently for the rapid andsensitive detection of nucleic acids, most notably reverse tran-scriptase PCR and nanoparticle-based biobarcodes [36], each ofwhich have a limit of detection in the tens o[r]

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DOI:http://dx.doi.org/10.7314/APJCP.2014.15.22.9607BRCA1 Promoter Hypermethylation for Detection of Breast Cancer in Viet NamRESEARCH ARTICLEBRCA1 Promoter Hypermethylation Signature for EarlyDetection of Breast Cancer in the Vietnamese Populat[r]

Radiotherapy is a chosen treatment option for prostate cancer patients and while some tumours respond well, up to 50% of patients may experience tumour recurrence. Identification of functionally relevant predictive biomarkers for radioresponse in prostate cancer would enable radioresistant patients[r]

Rebiopsy is highly recommended to identify the mechanism of acquired resistance to EGFR-TKIs in advanced lung cancer. Recent advances in multiplex genotyping based on circulating tumor DNA (ctDNA) provide a strong and non-invasive alternative for detection of the resistance mechanism.

and the clinical course after treatment. Some recently investigated new serum markers seem to be clinically useful, such as YKL-40 for cervical cancer and HE4 for endometrial and ovarian cancers. Recent breakthroughs in proteomics and bioinformatics technology will expand[r]

Since recent studies revealed the feasibility to detect blood-based microRNAs (miRNAs, miRs) in breast cancer (BC) patients a new field has been opened for circulating miRNAs as potential biomarkers in BC. In this pilot study, we evaluated to our knowledge for the first time whether distinct pattern[r]

Quality of cancer care (QoCC) has become an important item for providers, regulators and purchasers of care worldwide. Aim of this study is to present the results of some evidence-based quality indicators (QI) for prostate cancer (PC) at the population-based level and to compare the outcomes with da[r]

The detection of circulating tumor cells (CTCs) in peripheral blood (PB) of patients with breast cancer predicts poor clinical outcome. Cancer cells with stemness and epithelial-to-mesenchymal transition (EMT) features display enhanced malignant and metastatic potential.

Lung cancer is the second most common cancer and the leading cause of cancer death for both men and women. Although low-dose CT (LDCT) is recommended for lung cancer screening in high-risk populations and may decrease lung cancer mortality, there is a need to improve the accuracy of lung cancer scre[r]

1 min and the supernatant is aspirated with the aid of an elongated Pasteur pipette. Samples are then further centrifuged at 4000 g,at4°Cin a refrigerated centrifuge. Aliquots for gel analysis are freeze dried while the rest is kept at )80 °C until further u[r]

Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of colorectal cancer incidence and mortality attributable to the known risk factors in China.

Pathologic complete response (pCR) after neoadjuvant chemotherapy for breast cancer is associated with improved prognosis in aggressive tumor subtypes, including ERBB2- positive tumors. Recent adoption of pCR as a surrogate endpoint for clinical trials in early stage breast cancer in the neoadjuvant[r]

Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection a[r]

all tobacco products should carry specific warnings but only required the warnings to cover 4-8% of the front and back of the pack. Initially, the healthwarnings were in text form.The Tobacco Product Directive (2001/37/EC) introduced bolder health mes[r]

are diagnosed at advanced stages when the prognosis for 5-year survival is poor, whereas those women diagnosed withStage I cancer have a more than 90% chance of 5-year survival.Implementation of a highly sensitive and specific test for theearly[r]

This non-systematic review article aims to summarise the progress made in understanding the functional consequences of microRNA (miRNA) dysregulation in prostate cancer development, and the identification of potential miRNA targets as serum biomarkers for diagnosis or disease stratification.

The assessment of circulating tumor cells (CTCs) has been shown to enable monitoring of treatment response and early detection of metastatic breast cancer (MBC) recurrence. The aim of this study was to compare a well-established CTC detection method based on immunomagnetic isolation with a new, filt[r]

Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating microRNAs (miRNAs) in plasma suggested a promising role as GC biomarkers.

Gastric cancer remains the second leading cause of cancer-related deaths in the world. Successful early gastric cancer detection is hampered by lack of highly sensitive and specific biomarkers. Plasma membrane proteins participate and/or have a central role in the metastatic process of cancer cells[r]