COMPARATIVE ANALYSIS OF HOMOLOGOUS VERTEBRATE GENES

ator protein-2 mRNA levels are downregulated during the differentiationprocess. After completion of deletion construct analysis and mutagenesisand mobility shift assays, we concluded that collapsin response mediatorprotein-2 basal promoter activity is regulated by the transcription fac[r]

ing the leaves to hang downward. Other than thepetiole, the leaves seemed to develop normally and to beperfectly healthy, wit h no indicatio ns of altered waterrelations. On average, the transge nic poplars hadpetioles that were 15% shorter, and the angle betweenthe adaxial sid e of th[r]

The 14-3-3 family is a group of intracellular proteins found in all eukaryotic organisms. Humans have seven isoforms that serve as scaffolds to promote interactions of regulatory phospho-proteins involved in many vital cellular processes and previous studies have shown that disturbances in native 14[r]

The present study was concluded to document the hematological evaluation of three different treatment regimens in clinical cases of diaphragmatic hernia in buffaloes which were brought to TVCC, LUVAS Hisar during the research period. Three different NSAIDs were tried and categorized in three groups[r]

STAT1 has been attributed a function as tumor suppressor. However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes belonging to the interferon-related signature for a poor response to therapy.

Aberrant DNA methylation profiles are a characteristic of all known cancer types, epitomized by the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). Hypermethylation has been observed at CpG islands throughout the genome, but it is unclear which factors determine whether an individ[r]

Breast cancer (BC) is the most prevalent cancer in women and a major public health problem in Morocco. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels.

Glioblastoma is a highly malignant brain tumor for which no cure is available. To identify new therapeutic targets, we performed a mutation analysis of kinase genes in glioblastoma. Methods: Database mining and a literature search identified 76 kinases that have been found to be mutated at least twi[r]

Quantitative methylation-specific PCR (qMSP) analysis for determining the methylation status of (candidate) tumor suppressor genes has potential as objective and valuable test to triage high-risk human papillomavirus (hrHPV) positive women in cervical screening.

and all other reported dmdR-like genes. However, thefinding that protein P1 encoded by ORF3, locatedimmediately upstream of dmdR2, increases in responseto dmdR1 disruption suggests that the ORF3–dmdR2cluster is negatively regulated by the DmdR1 regulator.Indeed, Western blot analysis[r]

Glutathione S-transferase P1 (GSTP1) has been reported to function as a tumor suppressor gene in various types of human cancers. Aberrant methylation of tumor-related genes at the promoter regions can inactivate genes, which is important in the carcinogenesis of breast cancer.

The Wnt/β-catenin signaling pathway is an evolutionary conserved pathway, which has important functions in vertebrate early development, axis formation, cellular proliferation and morphogenesis.

We sought to determine the comparative diagnostic performance of standard b-value (800–1000 s/mm2 ) versus low b-value (400–500 s/mm2 ) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC).

With the development of sequencing technologies, there may be some disputes on sequencing analysis. The aim of this study was to investigate different allele frequency thresholds of mutations in targeted genes on prognostic analyses using a panel of cancer associated gene exons (CAGE) in oral squamo[r]

Two molecular techniques, RAPD and ISSR were used to study the genetic relatedness in 37 genotypes of chrysanthemum. With 27 RAPDs and 10 ISSRs, a total of 271 and 107 polymorphic bands were generated accounting to 97.4% and 93.86% polymorphism respectively. Both kinds of markers could able to disti[r]

Inhibition (%) = (A 0 – A 1 / A 0 ) × 100
Where, A 0 is the absorbance of control and A 1 is the absorbance of sample.
In order to calculate IC 50 value, plant extract solution in methanol was further diluted and tested for DPPH assay to find out 50% inhi[r]

Histologically similar tumors even from the same anatomical position may still show high variability at molecular level hindering analysis of genome-wide data. Leveling the analysis to a gene regulatory network instead of focusing on single genes has been suggested to overcome the heterogeneity issu[r]

Osteosarcoma is a highly genetically unstable tumor with poor prognosis. We performed microarray-based comparative genomic hybridization (aCGH), transcriptome sequencing (RNA-seq), and pathway analysis to gain a systemic view of the pathway alterations of osteosarcoma.

E.coli type II L-asparaginase is widely used for treatment of acute lymphoblastic leukemia. However, serious side effects such as allergic or hypersensitivity reactions are common for L-asparaginase treatment.

Although oral cavity, pharyngeal, oesophageal and gastric cancers share some risk factors, no comparative analysis of mortality rate trends in these illnesses has been undertaken in Spain. This study aimed to evaluate the independent effects of age, death period and birth cohort on the mortality rat[r]