MICRORNA EXPRESSION IN DISEASE

Current evidence implicates aberrant microRNA expression patterns in human malignancies; measurement of microRNA expression may have diagnostic and prognostic applications. Roles for microRNAs in head and neck squamous cell carcinomas (HNSCC) are largely unknown.

Predictive value of GCDFP-15 expression
We further evaluated if GCDFP-15 expression might have predictive value for response to NACT and performed lo- gistic regression analysis. In the total study group, there was a non-significant trend towards a reduced probability of pCR <[r]

Evaluate plasma microRNA-21 and microRNA-122 expression levels in hepatitis B virus-related hepatocellular carcinoma patients. Analyze the relationship between microRNA-21, microRNA-122 plasma with some clinical, subclinical and stage indicators in hepatitis B virus-related hepatocellular carcinoma[r]

In general, the miRNA strand, which has its 5 ¢ -ter- minus at the lowest thermodynamic stability, acts as the mature miRNA (guide strand), and the other strand (passenger strand) is degraded. However, a recent report has shown that both strands could be coaccumulated as miRNA pairs in[r]

Classification of biological samples of gene expression data is a basic building block in solving several problems in the field of bioinformatics like cancer and other disease diagnosis and making a proper treatment plan. One big challenge in sample classification is handling large dimensional and r[r]

For more than a decade, gene expression data sets have been used as basis for the construction of co-expression networks used in systems biology investigations, leading to many important discoveries in a wide range of subjects spanning human disease to evolution and the development of organisms.

MicroRNAs (miRNAs) offer great potential as cancer biomarkers. The importance of miRNAs profiling in tissue and body fluids in colorectal cancer (CRC) have been addressed respectively in many studies.

A key challenge of identifying disease–associated genes is analyzing transcriptomic data in the context of regulatory networks that control cellular processes in order to capture multi-gene interactions and yield mechanistically interpretable results.

Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby affecting and regulating the expression of mRNAs and target genes.

potential (Chaps. 79 and 80). Consequently, the major impact of genetic testing in these cases is to allow more intensive clinical screening, as it remains very challenging to predict disease penetrance, expression, or clinical course.
Although genetic diagno[r]

MicroRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. In terms of tumor-normal expression differences, many microRNAs exhibit evidence of being up-regulated in some subjects b[r]

the cancer statistics provided by American Cancer Soci- ety in 2012, the 5-year survival rate of NHL has im- proved from 47% in 1970s to 70% in recent years, and rituximab has been central to this improved prognosis. [2]. However, it is important to realize that after treat- m[r]

The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone.

presence of TLRs polymorphisms and susceptibility to a disease [20]. Since the available data indicate that there would not be a TLR polymorphism associated with COPD [21] in this study we analyzed whether the expression and/or functionality of TLRs was altered. We reasoned that[r]

Circulating microRNAs (miRNAs) play critical roles in pathogen–host interactions. Aberrant miRNA expression profiles might have specific characteristics for virus strains, and could serve as noninvasive biomarkers for screening and diagnosing infectious diseases. In this study, we aimed to find new[r]

Archival formalin-fixed paraffin-embedded (FFPE) cancer tissue samples are a readily available resource for microRNA (miRNA) biomarker identification. No established standard for reference miRNAs in FFPE tissue exists.

Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined.

Although microRNAs offer great potential as cancer biomarkers, effective clinical dignostics and tumor maker have not been verified to diagnose with colorectal cancer (CRC). The purpose of our study is to systematically assess the expression of miRNAs in matched cancer and normal tissue samples to i[r]

MicroRNAs are the key post-transcriptional regulators of gene expression in development and stress responses. Thus, precisely quantifying the level of each particular microRNA is of utmost importance when studying the biology of any organism.

Early diagnosis of RCC can be challenging. The classical clinical symptoms and signs of renal cancer are usually present only with late disease, when prognosis is poor; these symptoms ­ pain, palpable flank mass and hematuria ­ are present in only approximately 10%[r]