PATHOGENIC MECHANISMS OF ACTION

The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1MET as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells. Methods: We investigated effects of PRIMA-1MET on apoptosis, cell cycle, and induction of oxidative stress and autophagy in a panel of 6 STS[r]

PASSIVE VOICEWHAT IS VOICE? WHEN DO WE USE PASSIVE VOICE?VOICE IS the grammatical relationPassive voice is mainly used:3. WRITE THE FOLLOWING SENTENCES IN THE PASSIVE VOICE.FORM PAY ATTENTION TO VERB TENSES.(active or passive) of thea. When the action or theWe form the passive using BE[r]

development of antibiotic resistance among various strains of bacteria and fungi [8].This further escalates the problem, as existent drugs no longer remain effective in2controlling the spread of such deadly infections. Hence, development of alternativestrategies for restr[r]

Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers of high-risk mutations in other breast cancer susceptibility genes.

particle. It’s present that under nano-level, the properties of substances depend mainlyon the surface, and it lead to a completely various physic-chemical properties andfunctionalities (Buzea et al, 2007). Therefore, the effect, which is related to thesurface, referred to surface effects is[r]

Literature ReviewThe pathway for flavivirus entry into host cells is through clathrin-mediatedendocytosis, which is triggered by an internalization signal (di-leucine or YXXΦ) inthe cytoplasmic tail of the receptor (Chu and Ng, 2004a). Clathrin is assembled on theinside face of the pla[r]

3. Verbs of thought/belief: ĐT bày tỏ suy nghĩThinkBeliveUnderstaindSupposeEx: I (think) that she is beautiful nowThinkI (think) of a beautiful girl nowAm thinking4. Verbs of senseSense of smell  smellSense of taste  tasteSense of sight/seeing  seeSense <[r]

Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential prognostic biomarkers.

Five lines were crossed with four testers in L x T fashion to assess the general combining ability of parents, specific combining ability of crosses and to determine the mode of gene action involved in the inheritance of yield attributes and nutritional traits. The analysis of variance for combining[r]

One of the major controversies of contemporary medicine is created by an increased consumption of nicotine and growing evidence of its connection to cancer, which urges elucidation of the molecular mechanisms of oncogenic effects of inhaled nicotine.

Obesity and diabetes are two risk factors for cancer. To evaluate the association of body mass index (BMI) with cancer risk in diabetic patients may improve current understanding of potential mechanisms.

In the active voice, the stronger form, the subject of the sentence takes the action of the verb.. Our army won the battle.[r]

Our previous study suggested that the recurrent CHEK2 H371Y mutation is a novel pathogenic mutation that confers an increased risk of breast cancer. The purpose of this study was to investigate whether breast cancer patients with CHEK2 H371Y mutation were more likely to respond to neoadjuvant chemot[r]

Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings.

The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcriptional silencing of critical genes.

Cow urine therapy and all traditional practices from Indian systems of medicine have a strong scientific base. The cow has proved to be a boon in the areas of agriculture, science and technology, industry, energy, medicine etc. for the development of any nation, in addition being eco-friendly in nat[r]

MicroRNAs can be used in the prognosis of malignancies; however, their regulatory mechanisms are unknown, especially in pancreatic ductal adenocarcinoma (PDAC).

The present study was undertaken to evaluate the in vitro antibacterial activity of seventeen genotypes of Coriander leaves and seeds collected from Tarai and Kumaun regions of Uttarakhand state of India. The methanolic extracts of leaves and seeds genotypes were screened against four human pathogen[r]

aseptically cultured potato microtubers in vitro were used asdescribed by Lawrence et al. [14]. The microtubers wereimmersed for 5–10 min in a suspension of 14-day-old agarculture (mainly, spore mass) grown on Czapek’s agar [6]followed by incubation at 100% relative humidity for5 days at 22–2[r]

Making Master planFormal Kick offImplementation &amp; Deployment of TPMactivities all over the organisation:Jishu HozenOEE / Kobetsu KaizenPlanned MaintenanceTraining &amp; Skill developmentOffice TPMInitial Project ManagementSafety and EnvironmentalManagementComplete implementation <[r]