IN SILICO

doi:10.1111/j.1742-4658.2007.05713.xPreviously, we have shown by sensitivity analysis, that the oscillatorybehavior of nuclear factor (NF-jB) is coupled to free IkappaB kinase-2(IKK2) and IkappaBalpha(IjBa), and that the phosphorylation of IjBa byIKK influences the amplitude of NF-jB oscillations. We[r]

* Corresponding author AbstractBackground: In silico techniques are highly suited for both the discovery of new and developmentof existing vaccines. Enterohemorrhagic Escherichia coli O157:H7 (EHEC) exhibits a pattern oflocalized adherence to host cells, with the formation of microcolo[r]

less than previously thought, but did not allow us tofurther explore the limits of evolution in sequence space. Incontrast, using computational design methodologies, whichcan search much larger volumes of sequence space, wehave been able to produce a protein with a fold notpreviously seen [r]

identification and lead optimization. This approach, therefore builds upon the progress made in computational chemistry to achieve more accurate in silico docking and in information technology to design and operate large-scale Grid infrastructures. One potential limitatio[r]

by the cytomegalovirus promoter)-transfected cell lines were also implanted into the left thigh of mice as controls. The bioluminescenceactivity of three cell lines transfected with the firefly luciferase vector, controlled by the miRNA23 promoter, was greater than for cells trans-fected with promoter[r]

This work presents a computational analysis of the molecular characteris-tics shared by the adenylation domains from traditional nonribosomal pep-tide synthetases (NRPSs) and the group of the freestanding homologousenzymes: a-aminoadipate semialdehyde dehydrogenase, a-aminoadipatereductase and the p[r]

colon adenocarcinoma. JAMA 299, 425–436.55 Zhang L, Huang J, Yang N, Greshock J, Megraw MS,Giannakakis A, Liang S, Naylor TL, Barchetti A, WardMR et al. (2006) microRNAs exhibit high frequencygenomic alterations in human cancer. Proc Natl AcadSci USA 103, 9136–9141.56 Lujambio A, Ropero S, Ba[r]

nylylation state of GS is the major regulator but that a total of 40% of theregulation is mediated by ADP (22%), glutamate (10%), glutamine (7%) andATP (1%). The total steady-state ammonium assimilation flux is remarkablyrobust against changes in the ammonium concentration, but the fluxesthroug[r]

or a1–6 core fucose units [38] for distinct lectins and alsothe natural cell surface panel. In comparison withpublished data for the core-fucosylated neoglycoproteinBiF10-BSA [38], the properties of BiB10-BSA binding toacute myelogenous leukemic KG-1 cells, breast carcinomaDU4475 cells and co[r]

Nitrogen is an essential macromolecule necessary for suitable growth and development of plants by playing a vital role in biochemical and physiological functions throughout the life cycle. Early node 93 (ENOD93-1) gene is well known for significantly responding to both N induction and N reduction in[r]

characterize new sites of phosphorylation.Results: Mass spectrometry and in silico sequence analysis were used to identify phosphate siteson the BPV E1 protein and kinases that may recognize these sites. Five new and two previouslyknown phosphorylation sites were identified. A phosphat[r]

eases. In silico analysis using different computationalmethods, as well as laboratory experiments, indicatesthat many G-rich regions of chromosomes – rDNA, sin-gle-copy genes, recombination sites like those involvedin immunoglobulin class-switching and repetitivesequences including sat[r]

characterize new sites of phosphorylation.Results: Mass spectrometry and in silico sequence analysis were used to identify phosphate siteson the BPV E1 protein and kinases that may recognize these sites. Five new and two previouslyknown phosphorylation sites were identified. A phosphat[r]

of the soluble transhydrogenase UdhA. FEMS Microbiol. Lett.204, 247–252.35. Dauner, M., Storni, T. & Sauer, U. (2001) Bacillus subtilis meta-bolism and energetics in carbon-limited and excess-carbonchemostat culture. J. Bacteriol. 183, 7308–7317.36. Wendisch, V.F., de Graaf, A.A., Sah[r]

Chuyên đề 1: Ứng dụng quy trình Multiplex – PCR phát hiện đồng thời các tác nhân gây ngộ độc thực phẩm.CHUYÊN ĐỀ 2: ỨNG DỤNG KỸ THUẬT PCR HỖ TRỢ ĐỊNH DANH MỘT SỐ LOÀI VI SINH VẬTChuyên đề 3: Ứng dụng kỹ thuật PCR hỗ trợ định danh một số loài vi khuẩn lactic, từ đó ứng dụng trong lĩnh vực chăm sóc sứ[r]

14. Hartlieb B, Modrof J, Mühlberger E, Klenk HD, Becker S: Oligomer-ization of Ebola virus VP30 is essential for viral transcriptionand can be inhibited by a synthetic peptide. J Biol Chem 2003,278:41830-41836.15. Lupas A, Van Dyke M, Stock J: Predicting coiled coils from pro-tein sequences. Scienc[r]

is the homooligomerization of NP, which self-assemblesinto helical tubules, which are 17 nm in diameter,observed both in cells expressing recombinant NP and inMARV infected cells [8,9]. The formation of the large NP-induced tubules, which are composed of several hundredNP molecules, mo[r]

áp lực mực, và làm “chết” các bộ phận nén áp ở trong máy.Luôn để máy ở chế độ không tải:Nên để máy ở chế độ không tải kể cả lúc bạn không dùng tới nó, để bảo vệ đầu phun, giúp máy không bị ẩm mốc, tăng tuổi thọ máy, giúp mực không bị khô và biến chất. Điện năng và nhiệt cho hoạt động không tải rất n[r]