ALTERATIONS IN VENTILATION AND DIFFUSION

Basaloid squamous cell carcinoma presents with a preference for the head and neck region, and shows a distinct aggressive behavior, with frequent local recurrences, regional and distant metastasis. The alterations in the cadherin-catenin complex are fundamental requirements for the metastasis proces[r]

Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA copy number, i[r]

In the continuing revision of Diagnostic and Statistical Manual (DSM-V) “identity” is integrated as a central diagnostic criterion for personality disorders (self-related personality functioning). According to Kernberg, identity diffusion is one of the core elements of borderline personality organiz[r]

Alterations in the host cellular immune response allow persistent infections with High-Risk Human Papillomavirus (HR-HPV) and development of premalignant cervical lesions and cervical cancer (CC). Variations of immunosuppressive cytokine levels in cervix are associated with the natural history of CC[r]

Recent work led to recognize sessile serrated adenomas (SSA) as precursor to many of the sporadic colorectal cancers with microsatellite instability (MSI). However, comprehensive analyses of DNA methylation in SSA and MSI cancer have not been conducted.

The 14-3-3 family is a group of intracellular proteins found in all eukaryotic organisms. Humans have seven isoforms that serve as scaffolds to promote interactions of regulatory phospho-proteins involved in many vital cellular processes and previous studies have shown that disturbances in native 14[r]

squamous cell cancer
Akhileshwar Namani 1 † , Md. Matiur Rahaman 2 † , Ming Chen 2* and Xiuwen Tang 1*
Abstract
Background: NRF2 is the key regulator of oxidative stress in normal cells and aberrant expression of the NRF2 pathway due to genetic alterations in[r]

The apparent diffusion coefficient (ADC) is a highly diagnostic factor in discriminating malignant and benign breast masses in diffusion-weighted magnetic resonance imaging (DW-MRI). The combination of ADC and other pictorial characteristics has improved lesion type identification accuracy.

The purpose of this study is to identify if participation in an eccentric exercise protocol altered the Coleimpedance model parameters that represent localized bicep tissue bioimpedance. This supports continued efforts to identify which features of tissue bioimpedance may be effective markers to non[r]

Discussion
Colorectal cancer is genetically recognised with many re- ported alterations and mutations. However, most gen- omic analyses have been performed on tumour tissue material – with thousands or millions of cells analysed mixed together. Tumour tissue consists of several dif[r]

Augusto LF Marino 1 , Adriane F Evangelista 1 , René AC Vieira 2 , Taciane Macedo 1 , Ligia M Kerr 3 ,
Lucas Faria Abrahão-Machado 3 , Adhemar Longatto-Filho 1,5,6,7 , Henrique CS Silveira 1 and Marcia MC Marques 1,4*
Abstract
Background: MicroRNAs (miRNAs) are small, non-coding RNA mol[r]

Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigenetic processes in tumour formation and to identify characteristic DNA methylation and miRNA[r]

Antiangiogenic treatments have been shown to increase blood perfusion and oxygenation in some experimental tumors, and to reduce blood perfusion and induce hypoxia in others. The purpose of this preclinical study was to investigate the potential of dynamic contrast enhanced magnetic resonance imagin[r]

Kapo Saukkonen 1,2* , Jaana Hagström 2,3 , Harri Mustonen 1 , Anne Juuti 1 , Stig Nordling 3 , Pauliina Kallio 2 , Kari Alitalo 2 , Hanna Seppänen 1 † and Caj Haglund 1,2 †
Abstract
Background: The Wnt/ β -catenin pathway has a key role in regulating cellular processes and i[r]

Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have been suggested to comprise tumor suppressor genes or oncogenes, respectively.

Only 5–10 % of breast cancer cases is linked to germline mutations in the BRCA-1 gene and occurs early in life. Conversely, sporadic breast tumors, which represent 90-95 % of breast malignancies, have lower BRCA-1 expression, but not mutated BRCA-1 gene, and tend to occur later in life in combinatio[r]

Deregulated signal transducer and activator of transcription 3 (STAT3) signaling has been well documented in certain cancers. Alterations in specific negative regulators, such as protein inhibitor of activated STAT3 (PIAS3), may contribute to cancer development.

The diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in the differential diagnosis of pulmonary tumors remained debatable among published studies. This study aimed to pool and summary the relevant results to provide more robust evidence in this issue using[r]

There are some weaknesses of our study which include its retrospective design. This contributes to differences in the timing and method of assessment of clinical re- sponse as well as the different b-values used for the DWI studies. Variation in b-values occurred due to the adop[r]

Alterations in methylation patterns, miRNA expression, and stem cell protein expression occur in germ cell tumors (GCTs). Our goal is to integrate molecular data across platforms to identify molecular signatures in the three main histologic subtypes of Type I and Type II GCTs (yolk sac tumor (YST),[r]