CELL BIOLOGY OF PROSTATE CANCER AND MOLECULAR TARGETS

Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previous studies have linked chromosomal instability (CIN), which generates aneuploidy following[r]

Circular RNAs (CircRNAs) are biologically active RNAs. CDR1as is one such circRNA previously reported to be a microRNA-7 (miR-7) sponge, thereby regulating associated gene expression. The specific underlying molecular mechanisms of CDR1as biology, however, remain largely unknown.

Practical and laboratory diagnosis of tuberculosis from sputum smear to molecular biology 2015
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Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets HER2, has been shown pre-clinically to induce vascular changes that can increase delivery of[r]

In this paper, we present a targeted PCa imaging strategy using a real-time molecular photoacoustic imaging system integrated with a handheld US probe (PAI/US) and synthesized an integrin αvβ3 targeted probe based on ICG (cRGD–ICG).

contains DNA (deoxyribonucleic acid), a molecule whichcontains the instructions that control the activities of thecell (see Chapter 6). Within the nucleus an even moredeeply staining area is visible, the nucleolus, which ismade of loops of DNA from several chromosomes. Thenumber[r]

IntroductionAnimals are capable of producing proteins in response toenvironmental changes such as temperature elevation [1],exposure to oxidative stress [2], and myocardial ischemia[3, 4]. These proteins are highly conserved among variousS. Jiang (&) Á L. Qiu Á F. Zhou Á J. Hua[r]

Adult stem cells are crucial for maintaining proper function and repair of tissues. The epithelium of the adult mammalian intestine is a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation and ultimately cell death. The epit[r]

Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion.

... interaction for intracellular uptake after the nanocarriers reach the target site from blood circulation and extravasation There are advantages and drawbacks for each of this strategy that will... and Y Y Yang, “Advanced Materials for Co -Delivery of Drugs and Genes in Cancer Therapy,” Advanced[r]

The objective of this study was to investigate real-world EGFR mutation testing in patients with metastatic non-small cell lung cancer (NSCLC) upon progression on first−/second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI), and subsequent treatments received.

We investigated whether head and neck squamous cell carcinoma (HNSCC) patient-derived xenografts (PDXs) reaffirm patient responses to anti-cancer therapeutics.

Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-receptors, inhibiting development of new blood vessels.