ROLE OF CA 2 IN CELL REGULATION

CHAPTER 23 – ROLE OF ABCA1 IN CELL TURNOVER AND LIPID HOMEOSTASIS CHAPTER 23 – ROLE OF ABCA1 IN CELL TURNOVER AND LIPID HOMEOSTASIS CHAPTER 23 – ROLE OF ABCA1 IN CELL TURNOVER AND LIPID HOMEOSTASIS CHAPTER 23 – ROLE OF ABCA1 IN CELL TURNOVER AND LIPID HOMEOSTASIS CHAPTER 23 – ROLE OF ABCA1 IN CELL T[r]

Uterine carcinosarcoma (UCS) represents a true example of cancer associated with epithelial-mesenchymal transition (EMT), which exhibits cancer stem cell (CSC)-like traits. Both Sox and β-catenin signal transductions play key roles in the regulation of EMT/CSC properties, but little is known about t[r]

Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL.

Cell lines and cell types are extensively studied in biomedical research yielding to a significant amount of publications each year. Identifying cell lines and cell types precisely in publications is crucial for science reproducibility and knowledge integration.

Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms for the highly invasive behavior of gliomas are still poorly understood.

Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of peptidylarginine deiminase 2 (PAD2, aka PADI2) activity appears to maintain basement membrane integrit[r]

When compared with relative gene abundance of FGF-2 treated cells Figure 3 we found that in general, BMP-2 maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significan[r]

Neovascularization and peritumoral edema are hallmarks of glioblastoma (GBM). Programmed cell death 10 (PDCD10) plays a pivotal role in regulating apoptosis, neoangiogenesis and vessel permeability and is implicated in certain tumor signaling pathways.

A comparable theory can be proposed for p53. p53 may promote oxidative stress while inducing apopto- sis 102–104 , but it also has an important role in reducing oxi- dative stress as a defence mechanism 105,106 . Glutaminase 2 (Gls2) is upregulated by p53 and drives de novo synthesis of GsH 107[r]

Epigenetic modifications play important roles in the regulation of gene expression determining cellular phenotype as well as various pathologies such as cancer. Although the loss of keratin 13 (KRT13) is reportedly linked to malignant transformation of oral epithelial cells, the molecular mechanisms[r]

The purpose of this study was to investigate the role of isocitrate dehydrogenase 1 (IDH1) expression on prognosis of patients with clear cell renal cell carcinoma (ccRCC) following nephrectomy.

Interestingly, in E2A/, the noticeable alterations in gene expression of survivin and IAP2 accompanied by unchanged gene expression of caspase-8 and also various B cell-specific factors, [r]

The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Polycomb group of proteins plays an important role in the regulation of stem cell self-renewal and is elevated in several cancers. In the current study, we have explored the role of Bmi1 in regulating the stemness a[r]

Applications of Stem Cell Biology in Clinical Medicine APPLICATIONS OF STEM CELL BIOLOGY IN CLINICAL MEDICINE: INTRODUCTION TRANG 2 SOURCES OF STEM CELLS FOR TISSUE REPAIR Different type[r]

Oestrogen receptors (ER) have a well-established role to the initiation, progression and regulation of responses to treatment of breast, prostate, and lung cancers. Previous data indicates altered ER expression in oesophageal cancers (OC).

To improve current treatment strategies for patients with aggressive colorectal cancer (CRC), the molecular understanding of subgroups of CRC with poor prognosis is of vast importance. SOX2 positive tumors have been associated with a poor patient outcome, but the functional role of SOX2 in CRC patie[r]

Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism.

Cervical carcinoma is the second most common cancer and is an important cause of death in women worldwide. CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular differentiation and proliferation in a variety of tissues. However, the role of C/EBPα gene[r]

Immunologic factors can promote the progression of oral squamous cell carcinomas (oscc). The phylogenetic highly conserved protein Galectin 3 (Gal3) contributes to cell differentiation and immune homeostasis. There is evidence that Gal3 is involved in the progression of oscc and influences the regul[r]

... Establishing the stress models 2.2 Investigation of the role of the NI in stressor-induced HP-mPFC LTP modulation Role of the NI in stress-induced modulation of mPFC-mediated working memory The current... research implicates the potential role of an emerging structure, the nucleus incertus (NI)[r]