LESSONS FROM AUTOIMMUNITY AND IMPLICATIONS FOR BRAIN TUMOR THERAPY

(1997) ÔCross talkÕ between opioid peptide and adrenergic recep-tor signaling in isolated rat heart. Circulation 95, 2122–2129.30. Yu, X.C., Li, H.Y., Wang, H.X. & Wong, T.M. (1998) U50,488Hinhibits effects of norepinephrine in rat cardiomyocytes – crosstalk between j-opioid and[r]

compared with either one in limiting brain infarction area (BIA) and preserving neurological function in rat afterischemic stroke (IS).Methods: Fifty adult-male SD rats were equally divided into sham control (group 1), IS plus intra-peritonealphysiological saline (at 0.5/24/48 h after[r]

Neoadjuvant chemoradiotherapy (NACRT) followed by surgical resection is the standard therapy for locally advanced rectal cancer. However, tumor response following NACRT varies, ranging from pathologic complete response to disease progression.

14. Debinski W, Obiri NI, Powers SK, Pastan I, Puri RK: Human glioma cellsoverexpress receptors for interleukin 13 and are extremely sensitive to anovel chimeric protein composed of interleukin 13 and pseudomonasexotoxin. Clin Cancer Res 1995, 1:1253-8.15. Cobbs CS, Harkins L, S[r]

© 2011 De Backer et al; licensee Springer. This is an Open Acce ss arti cle distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/li censes/by/2.0), which permits unrestricted use, di stribution, and rep roduction inany medium, provided the origina[r]

Published: 28 January 2009Journal of Translational Medicine 2009, 7:11 doi:10.1186/1479-5876-7-11Received: 27 December 2008Accepted: 28 January 2009This article is available from: http://www.translational-medicine.com/content/7/1/11© 2009 Li et al; licensee BioMed Central Ltd. This is an Open[r]

We also verified that both the patient ’ s biopsy material as well as the xenografted GBM cells injected into mouse
brain were negative for IDH1 – R132H mutation. This re- cently described mutation in isocitrate desidrogenase enzyme type 1 (IDH1) seems to be frequent in diffuse gli-[r]

Chapter 092. Testicular Cancer (Part 6) Fertility Infertility is an important consequence of the treatment of GCTs. Preexisting infertility or impaired fertility is often present. Azoospermia and/or oligospermia are present at diagnosis in at least 50% of patients with testicular GCTs. Ejacu[r]

after thrombolysis is related to severity and duration of ischemia: MRIFigure 10 The proposed mechanisms underlying the protective actions of cyclosporine and erythropoietin in rats after ischemicstroke.Yuen et al. Journal of Translational Medicine 2011, 9:141http://www.translational-m[r]

To prospectively assess circulating tumor cell (CTC) status at baseline (CTCBL) and after one cycle of a new line of systemic therapy (CTC1C), and changes from CTCBL to CTC1C (CTC kinetics, CTCKIN) for their utility in predicting response, progression-free (PFS) and overall survival (OS) in metastat[r]

Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient subgroups who benefit from anti-angiogenic therapy are not yet defined.

mL normal saline, and this solution is injected through the chest tube. The chest tube is clamped for 4 h if tolerated, and the patient is rotated onto different sides to distribute the sclerosing agent. The chest tube is removed 24–48 h later, after drainage has become slight ([r]

Chapter 077. Approach to the Patient with Cancer (Part 11) Effusions Fluid may accumulate abnormally in the pleural cavity, pericardium, or peritoneum. Asymptomatic malignant effusions may not require treatment. Symptomatic effusions occurring in tumors responsive to systemic therapy usually[r]

Polymorphisms in MTHFR gene influence risk and overall survival of patients with brain tumor. Global genomic DNA (gDNA) methylation profile from tumor tissues is replicated in peripheral leukocytes.

Many patients with cancer suffer from distress, anxiety and depression. However, studies on patients with brain metastases are lacking. In this exploratory study we prospectively assessed distress, anxiety and depression in patients with brain metastases from different solid primary tumour treated w[r]

least one first-line anti-TB drug. As an effective DOTS-based response to MDR TB, global health authorities adopted DOTS-Plus, which adds the diagnostics and drugs necessary to manage drug-resistant disease. Even before DOTS-Plus could be brought to scale in resource-constrained settings, how[r]

Africa and Central Asia are over-represented in global tuberculosis statistics. Although the Africanregion contributes only about 11% of the world population, it accounts for at least 25% of annualTB notifications, a proportion that continues to increase due to poor case management [r]

methodologies had to resort to both top down and bot-tom up accounting, which allow for more reliable, if time-consuming, cost calculations [26,27]. Furthermore, onlythe basic areas of wage bills, initial and on-the-job-train-ing (elsewhere referred to as 'continuous medical edu[r]

™ACTIVATINGVOCABULARYPhotocopiable Teacher Resources:FOR ESOL LEARNERS

Undifferentiated pleomorphic sarcoma (UPS) is a heterogeneous tumor group, and little is known about molecular target therapy for UPS. Heat shock protein 90 (HSP90) is an expressed chaperone that refolds certain denatured proteins under stress conditions.