STEM CELL

Chapter 066. Stem Cell Biology (Part 2) Self-Renewal and Proliferation of Stem Cells Symmetric and Asymmetric Cell Division The most widely accepted stem cell definition is a cell with a unique capacity to produce unaltered daughter cells (self-renew[r]

40-52.10. Sadikovic B, Thorner P, Chilton-Macneill S, Martin JW, Cervigne NK, Squire J,Zielenska M: Expression analysis of genes associated with humanosteosarcoma tumors shows correlation of RUNX2 overexpression withpoor response to chemotherapy. BMC Cancer 2010, 10:202.11. Won KY, Kim YW, Park YK:[r]

Chapter 068. Hematopoietic Stem Cells (Part 4) Hierarchy of hematopoietic differentiation. Stem cells are multipotent cells that are the source of all descendant cells and have the capacity to provide either long-term (measured in years) or short-term (measured in months) cell[r]

40-52.10. Sadikovic B, Thorner P, Chilton-Macneill S, Martin JW, Cervigne NK, Squire J,Zielenska M: Expression analysis of genes associated with humanosteosarcoma tumors shows correlation of RUNX2 overexpression withpoor response to chemotherapy. BMC Cancer 2010, 10:202.11. Won KY, Kim YW, Park YK:[r]

cells were compared with HbE/b-thalassemia and normal HSCs.Results: A significant change in abundance of 229 phosphoproteins was demonstrated. Importantly, the analysis ofthe candidate proteins revealed a high abundance of proteins that are commonly found in apoptotic cellsincluding cytochrome C, ca[r]

Vats A et al: Stem cells. Lancet 366:592, 2005 [PMID: 16099296]

cells were compared with HbE/b-thalassemia and normal HSCs.Results: A significant change in abundance of 229 phosphoproteins was demonstrated. Importantly, the analysis ofthe candidate proteins revealed a high abundance of proteins that are commonly found in apoptotic cellsincluding cytochrome C, ca[r]

to characterize and classify various stem cells and the molecular mechanisms that give them their unique characteristics. Stemness This term has been used to designate the essential molecular characteristics of stem cells. It is also used to indicate common genetic programs shared amon[r]

2003, 100:3983-3988.22. Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ: Prospectiveidentification of tumorigenic prostate cancer stem cells. Cancer Res 2005,65:10946-10951.23. Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A,Huang EH, Simeone DM, Shelton AA, Parmian[r]

Polypyrimidine tract-binding protein is essential for earlymouse development and embryonic stem cell proliferationMasaki Shibayama*, Satona Ohno*, Takashi Osaka, Reiko Sakamoto, Akinori Tokunaga,Yuhki Nakatake, Mitsuharu Sato and Nobuaki YoshidaLaboratory of Developmental Genetics, Cen[r]

Multipotent adult stem cells (MAPC) MAPCs can be derived by culturing bone marrow mononuclear cells, after depleting CD45+ and GlyA+ cells, with FCS, EGF, and PDGF-BB (h). MAPCs are very rare cells that are present within MSC cultures from postnatal bone marrow (m, h). MAPCs can also be isola[r]

Page 2 of 9immune-competent mice. In the evolution of the tumor,the phenotype and genotype of precancerous stem cellshad developed towards primary cancer stem cells.Interestingly, Shen et al [62] discovered that the pre-cancerous stem cells could differentiate into tumo r vas-cu[r]

free mouse embryonic stem cells. Parallel activity of STAT3 andSmad leads to inhibition of differentiation programs induced by theother pathway, thereby upholding the pluripotent state of the cells.The balance is easily broken upon signal increase in any direction.BMP signaling in stem[r]

ES cells has been controversial, and their use in clinical applications would be unacceptable to some patients and physicians despite their enormous potential. Somatic cell nuclear transfer ("therapeutic cloning") represents an alternative method for creating ES cell lines that are gen[r]

At present, many types of primary cancer stem cellswith specific surface mark ers have been isolated and thecancer stem cell hypothesis is widely accepted. However,many questions remain in the field of cancer stem cellsresearch. For example, where primary cancer stem