IN CLINICAL FEATURES OF ALZHEIMER S DISEASE

cells. This was true in both normal and Alzheimer’s disease brain sections.We also demonstrate that RCAN1-1 mRNA levels are approximately two-fold higher in neurons from Alzheimer’s disease patients versus non-Alzhei-mer’s disease[r]

association study identifies variants at CLU and PICALM associated withAlzheimer’s disease. Nat Genet 2009, 41:1088-1093.6. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M,Combarros O, Zelenika D, Bullido MJ, Tavernier B, et al: Genome-wideassociation study identi[r]

whereby osteoarthritis resulted in neuroinflammation as well as exacerbation and acceleration of AD pathology.Results: Induction of osteoarthritis exacerbated and accelerated the development of neuroinflammation, asassessed by glial cell activation and quantification o[r]

17. Kamer A, Craig R, Dasanayake A, Brys M, Glodzik-Sobanska L, de Leon M:Inflammation and Alzheimer’s disease: Possible role of periodontaldiseases. Alzheimers Dement 2008, 4:242-250.18. Pepys M, Hirschfield G: C-reactive protein: a critical update. J Clin Invest2003, 11[r]

nal degeneration marker tau. More importantly, cogni-tively healthy elderly individuals, with increased risk ofdeveloping AD in the future, had elevated CSF MMP-3and MMP-9 levels and an increased CSF MMP-3/TIMP-1 ratio, indicating that MMP-3 and MMP-9might be involved in early pathogen[r]

cc107, Universite´de Montpellier II, place E.Bataillon, 34095 Montpellier cedex 5, FranceFax: +33 0467144727Tel: +33 0467144775E-mail: marcilhac@univ-montp2.fr(Received 23 March 2006, accepted 31 May2006)doi:10.1111/j.1742-4658.2006.05352.xApoptotic neuronal cell death is the cardinal feature of<[r]

Tanzi R, Jones K, Hyman BT, Albert MS. 2000. Use of structuralmagnetic resonance imaging to predict who will get Alzheimer’sdisease [see comments]. Ann Neurol 47(4):430–9.[34] Kleinbaum DG, KLL, MKE. 1988. Applied Regression Analysis andOther Multivariable Methods, p. 601–31, second ed[r]

with tau in homogenates of the medial temporal cortex from 20 AD and10 control brains. We found that levels of p-mTOR (Ser2481), and p-4E-BP1 (Thr70 and Ser65) dramatically increase in AD, and are positively sig-nificantly correlated with total tau and p-tau. Levels of<[r]

2006). The active form of IL-18 induces signal transduction by binding to itsreceptor, IL-18α/β receptor (IL1Rrp/IL1RAPL) expressed by diverse cell types,including neurons and glia cells. In adult brains of untreated BALB/c mice, IL-18 isconstitutively the most highly expressed[r]

Modulation of a-synuclein aggregation by dopamine in thepresence of MPTP and its metabolitePrashant N. Jethva, Jay R. Kardani and Ipsita RoyDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar,[r]

cursor to amyloidosis: a discussion of the occurrence, role, andimplications. In Molecular Chaperones in the Cell (Lund, P., ed.),Frontiers in Molecular Biology Series, pp. 257–278. OxfordUniversity Press, Oxford.63. Carrel, R.W. &amp; Gooptu, B. (1998) Conformational[r]

, J. MAROCO4, M.R. SIMOES5,D. GALASKO6, A. DE MENDONCA1,71. Dementia Clinics, Institute of Molecular Medicine and Faculty of Medicine of Lisbon, Lisbon, Portugal; 2. Neurology Clinics, Hospital of Santo André, Leiria, Portugal; 3. Laboratoryof Language, Institute of