DERIVATION AND MAINTENANCE OF EMBRYONIC STEM CELLS

stem cells. Mouse ES cells can form teratomas when injected into immunosuppressed animals. Potency and Differentiation of Stem Cells Developmental Potency The term potency is used to indicate a cell's ability to differentiate into specialized cell typ[r]

caution as it may not be function for stem cells. Cultured Stem Cells It is desirable to culture and expand stem cells in vitro to obtain a sufficient quantity for analysis and potential therapeutic use. Although the derivation of[r]

Germ cell neoplasia in situ (GCNIS), is preinvasive stage of testicular germ cell tumours (TGCTs). Fibrillins, which are integral components of microfibrils are suggested to be involved in cancer pathogenesis and maintenance of embryonic stem cells pluripotency. The aim of this study was to examine[r]

Private health companies will patent procedures andfix their own prices for treatment. Is this acceptable?✁Student AEmbryonic stem cells: These are the first cells of life, found in a newly fertilisedhuman egg. Each embryonic stem cell has the capacity, with[r]

, vols 1 and 2. London, Elsevier Academic Press, 2004 Marshak DR et al (eds): Stem Cell Biology, New York, Cold Spring Harbor Laboratory Press, 2001 Odorico J et al (eds): Human Embryonic Stem Cells. New York, BIOS Scientific Publishers, 2005

Nutrition Exercise Physiology and Sarcopenia Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USAStephen M. RothDepartment of Kinesiology, School of Public Health, University of Maryland, Colle[r]

In the present study, we demonstrate that S100A4 is up-regulated in MB49 bladder cancer stem cells (MCSCs). Additionally, overexpression of S100A4 en- hances the proliferation capacity of MCSCs in vitro, and also upregulates inhibitor of nuclear factor kap[r]

The side population (SP) of cancer cells is reportedly enriched with cancer stem cells (CSCs), however, the functional role and clinical relevance of CSC marker molecules upregulated in the SP of head and neck squamous carcinoma (HNSCC) cells are yet to be elucidated.

Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) Harrison's Internal Medicine > Chapter 67. Applications of Stem Cell Biology in Clinical Medicine Applications of Stem Cell Biology in Clinical Medicine: Introduction Organ[r]

Stem cell protein Piwil1 functions as an oncogene in various tumor types. However, the exact function and mechanism of Piwil1 in endometrial cancer remains unclear. Our results suggested that stem cell protein Piwil1 play important roles in regulating EMT and the acquisition of stem-like properties[r]

Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) Strategies for Stem Cell Replacement Stem cell transplantation is not a new concept and it is already part of established medical practice. Hematopoietic stem cells ([r]

Emerging evidences proposed that microRNAs are associated with regulation of distinct physiopathological processes including development of normal stem cells and carcinogenesis. In this study we aimed to investigate microRNA profile of cancer stem-like cells (CSLCs) isolated form freshly resected la[r]

Cancer stem cells are hypoxia-resistant and present a preponderant glycolytic metabolism. These characteristics are also found in basal-like breast carcinomas (BLBC), which show increased expression of cancer stem cell markers.

Chapter 108. Hematopoietic Cell Transplantation (Part 2) With current techniques, the risk of graft rejection is 1–3%, and the risk of severe, life-threatening acute GVHD is ~15% following transplantation between HLA-identical siblings. The incidence of graft rejection <[r]

Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse.

Elucidating the precise properties of cancer stem cells (CSCs) is indispensable for the development of effective therapies against tumors, because CSCs are key drivers of tumor development, metastasis and relapse.

Label-retaining cancer cells (LRCC) have been proposed as a model of slowly cycling cancer stem cells (CSC) which mediate resistance to chemotherapy, tumor recurrence, and metastasis. The molecular mechanisms of chemoresistance in LRCC remain to-date incompletely understood.

Chapter 068. Hematopoietic Stem Cells (Part 5) Some limited understanding of self-renewal exists and, intriguingly, implicates gene products that are associated with the chromatin state, a high-order organization of chromosomal DNA that influences transcription. T[r]

Recent evidence in cancer research, developed the notion that malignant tumors consist of different subpopulations of cells, one of them, known as cancer stem cells, being attributed many important properties such as enhanced tumorigenicity, proliferation potential and profound multidrug resistance[r]

Emerging evidence indicates that inappropriate cell-cell fusion might contribute to cancer progression. Similarly, mesenchymal stem cells (MSCs) can also fuse with other cells spontaneously and capable of adopting the phenotype of other cells. The aim of our study was to investigate the role of MSCs[r]