SELECTION EMERGENCE AND EVOLUTION OF DRUG RESISTANCE

Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cancer, and emergence of drug resistance underscore the need to develop new, potentially less to[r]

This study was conducted to evaluate the effect of salinity on germination and emergence of chilli cultivars and to investigate the ability for genetic salt tolerance during germination and seedling growth. Although some of the chilli genotypes have salinity tolerance to some extent, more attention[r]

The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive cancers display de novo resistance to tamoxifen, and acquired resistance evolves in 40 % o[r]

In breast cancer, the epithelial to mesenchyme transition (EMT) is associated to tumour dissemination, drug resistance and high relapse risks. It is partly controlled by epigenetic modifications such as histone acetylation and methylation.

This study aimed to investigate the bacterial contamination of flake and cube ice being used daily in the community. Thirty-one ice samples were collected from different areas in the city of Can Tho, Vietnam. The enumeration of total aerobic mesophilic counts, presence of coliforms and Escherichia c[r]

Escherichia coli is the most common organism causing urinary tract infection (UTI). This organism has the ability to produce Extended Spectrum Beta Lactamases (ESBLs), which confer multiple drug resistance making urinary tract infection difficult to treat. So treatment of UTI requires constant updat[r]

Drug resistance is a cause of ovarian cancer recurrence and low overall survival rates. There is a need for more effective treatment approaches because the development of new drug is expensive and time consuming.

squamous cell cancer
Akhileshwar Namani 1 † , Md. Matiur Rahaman 2 † , Ming Chen 2* and Xiuwen Tang 1*
Abstract
Background: NRF2 is the key regulator of oxidative stress in normal cells and aberrant expression of the NRF2 pathway due to genetic alterations in the KE[r]

Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular active metabolite ara-G triphosphate (ara-GTP) by both cytosolic deoxycytidine kinase and mitoch[r]

The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular processes such as DNA replication and transcription. These DNA adducts can effectively induce cancer cell death, however, there are a range of clinical side effects and drug res[r]

The expression alterations of B4GALT1 have been noted in some types of cancer and they are related to cancer cell proliferation, invasiveness, metastasis, and drug resistance. We aimed to establish the expression of B4GALT1 in bladder cancer and its connection to patient outcomes, as well as forecas[r]

The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Polycomb group of proteins plays an important role in the regulation of stem cell self-renewal and is elevated in several cancers. In the current study, we have explored the role of Bmi1 in regulating the stemness a[r]

Coagulase Negative Staphylococci (CONS) are the indigenous flora of the human skin and mucous membrane. They are usually contaminants, when isolated from clinical specimens. CONS have become important nosocomial pathogens, accounting for 9% of all nosocomial infections. These infections are difficul[r]

The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is inevitable for many cancer patients, despite many improvements in drugs and their use over the last 40 years.

The main structural proteins are formed by cleavage of the Pr55 Gag polyprotein into matrix (MA; p17), capsid (CA; p24), nucleocapsid (NC; p7), p6 Gag, and two spacer peptides, p2 and p1.

High phenotypic coefficient of variation and genotypic coefficient of variation were observed for percent potato apical leaf-curl disease (PALCD) incidence at 40, 60 and 80 DAP, whitefly population at 20 and 30 DAE and phenols. High heritability (broad sense) along with genetic advance as per cent o[r]

Efficiency of colorectal carcinoma treatment by chemotherapy is diminished as the resistance develops over time in patients. The same holds true for 5-fluorouracil, the drug used in first line chemotherapy of colorectal carcinoma.

Development of resistance to conventional drugs and novel biological agents often impair long-term chemotherapy. HMGA gene overexpression is often associated with antineoplastic drug resistance and reduced survival.

Glioma stem cells (GSCs) contribute to tumor recurrence and drug resistance. This study characterizes the tumorigenesis of CD133+ cells and their sensitivity to pharmacological inhibition.

Doxorubicin (Dox) is widely used to treat progressed bladder cancer after transurethral resection. The use of Dox-chemotherapy has been limited due to induced drug resistance and cumulative cardiotoxic effects. N-benzyladriamycin-14-valerate (AD198), a novel derivative of Dox, has a potential to bec[r]