POST-TRANSLATIONAL MODIFICATION

lactosamine addition during maturation. This modificationof CD63 was accompanied by a change in morphology ofMHC class II compartments from typical multivesicularorganelles to structures containing densely packed lipidmoieties. Post-translational modification of CD63 may beinvolved in th[r]

RhoA mRNA levels (Fig. S3). Distinguishing betweenthe two latter possibilities proved to be more challeng-ing. Our results indicate that RhoA can be deubiquiti-nated by OTUB1 directly, but not by the catalyticallyinactive mutant (Fig. 7C). This is supported by the factthat the catalytically inactive[r]

2007, accepted 25 June 2007)doi:10.1111/j.1742-4658.2007.05952.xUbiquitin specific protease 7 (USP7) belongs to the family of deubiquitinat-ing enzymes. Among other functions, USP7 is involved in the regulation ofstress response pathways, epigenetic silencing and the progress of infectionsby DNA viru[r]

Website: http://www.mpi-marburg.mpg.de/(Received 11 June 2007, revised 23 July2007, accepted 26 July 2007)doi:10.1111/j.1742-4658.2007.06016.xMethyl-coenzyme M reductase (MCR) catalyzes the methane-forming stepin methanogenic archaea. Isoenzyme I from Methanothermobacter marbur-gensis2was shown to c[r]

egies for mimicking PTM. Taken from [4].D. P. Gamblin et al. Exploring post-translational modificationFEBS Journal 275 (2008) 1949–1959 ª 2008 The Authors Journal compilation ª 2008 FEBS 1951catalyze enhanced hydrolytic degradation of the targetprotein.More recently, the glycoMTS method[r]

variable block 1. However, the few glycosylation sitesobserved in MEME block 1 are not conserved and in factcontains the ASN site with the highest entropy and itsinvolvement in the co-mutating pairs suggests specific andselected base pair substitutions over the years. The rela-tively high co-mutatin[r]

ger S & Mann M(2007) Mass spectrometric mapping of linker histoneH1 variants reveals multiple acetylations, methylations,and phosphorylation as well as differences between cellculture and tissue. Mol Cell Proteomics6, 72–87.44 Snijders AP, Pongdam S, Lambert SJ, Wood CM, Bald-win JP &amp[r]

each other and, in the D71N mutant, the chargedArg361 is expected to have an isolated buried charge,which may destabilize the protein.ConclusionsCRMP-2 is a central regulator of axonal growth coneguidance, and its function is likely to involve bothhomo- and heterotetramerization, as well as post<[r]

AbstractCutaneous melanoma is a very aggressive neoplasia of melanocytic origin with constantly growing incidence and mortality rates world-wide. Epigenetic modifications (i.e., alterations of genomic DNA methylation patterns, of post-translational modifications of histones, and of mic[r]

(JTM)established "The Excellence in Translational MedicineAward" in 2006 [1]. With the thought to also recognizeexcellent studies, defined as those exclusively based on thestudy of human subjects, the Editorial Board has furtherestablished "The Bedside-to-Bench Award" in 2008 [2].The recipien[r]

clinical models that could help prioritize products forclinical testing, the lack of predictive biomarkers thatcould help patient selection and the lack of surrogatebiomarkers that could help with the assessment of prod-uct efficacy early in development.All of us who have been dedicated from the beg[r]

277Security ThreatsIt is possible that crackers will break into your system and format your hard drive. It isfairly likely that a careless programmer or administrator will delete something by acci-dent, and it is almost certain that you will occasionally lose a hard disk drive. Hard diskdrives rotat[r]

Once the path has been discovered, the source updates its routing table and includes the path details in the routing information field in the transmitted frame. 10.4.3 SRT and translational bridges When connecting Ethernet networks to token ring networks, either source-routing transparent (SR[r]

Chapter 2: Types of Attacks21MODIFICATION ATTACKSA modification attack is an attempt to modify information that an attacker is not autho-rized to modify. This attack can occur wherever the information resides. It may also be at-tempted against information in transit. This type of attac[r]

To investigate the relative efficiency of FIH-catalysed histidinyl versus asparaginyl and aspartyl hydroxyla-tions under standard conditions, we individually replaced the His residue at t[r]

TRANG 1 49 APPENDIX A COMPARISON OF INITIATIVES FOR THE 2008 CONTRACT AND 2009 MODIFICATION # 2008 CONTRACT INITIATIVES # SIGNIFICANT REVENUE GENERATING 2009 CONTRACT MODIFICATION INITIA[r]

specialized cells of the X organ–sinus gland neurosecretory system and thatthe d-forms of the two neuropeptides are not only present in the samecells, but, importantly, also are co-packaged within the same secretoryvesicles.AbbreviationsCHH, crustacean hyperglycaemic hormone; DAACP,D-amino acid cont[r]

residues in the C surface interactions and points tothem being necessary for helix or spiral formation.This, in turn, implicates structural changes resultingfrom this interaction in the activation of the enzymethat occurs on oligomerization.An open question is the reason for the cleavage atposition[r]