ROLE OF IL 7 IN IMMUNE RECONSTITUTION AFTER HAART OR HAART PLUS IL 2 AND PRECLINICAL ASSESSMENT OF I...

ST2, a member of the interleukin (IL)-1receptor family, regulates Th1/Th2 immune responses in autoimmune and inflammatory conditions. However, the role of ST2 signaling in tumor growth and metastasis of breast cancers has not been investigated. This study investigated the possible role of soluble ST[r]

Discussion
Our present data provide the first evidence that ATL inhibits the infiammatory activation of microglia. To date, two separate LXA 4 receptors (ALX1/FPR-rs1 and ALX2/FPR2) have been identified in mice [15,29]. Mouse ALX2/FPR2 is expressed by neutrophi[r]

subsequently reinfused into patients. Preclinical studies have shown that, when laboratory animals are immunized with dendritic cells previously pulsed with MHC class I–restricted peptides derived from tumor-specific antigens, pronounced antitumor cytotoxic T-lymphocyte responses and[r]

Trout IL-11 cDNA cloning
To clone full-length trout IL-11 cDNA, a SMART cDNA library was constructed from bacterial-challenged liver tis- sues, as high expression of IL-11 was seen after bacterial infection in initial RT–PCRs. Briefly, SMART cDNA was synthe[r]

Considering the potential of p16 as a marker for diagnosis, prognosis and therapeutic response, the aim of this study was to assess its presence, via immunocytochemistry, in metastatic carcinoma of different primary sites and histological types obtained from effusions and peritoneal washings.

The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors (INSR, IGF1R, IGF2R), ligands (INS, IGF1, IGF2), and binding proteins (IGFBP1–7, IGF2BP1–3[r]

In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype.

The anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2; MDC-22), a novel derivative of aspirin, and evaluated its chemotherapeutic and chemopreventive efficacy in preclinical models of triple nega[r]

In this article, we propose a mechanism by which Av17 triggers macrophages to produce IL-10, but how this immunomodulatory protein binds to the macro- phage is still an open question. The malarial parasite Plasmodium falciparum produces proteins that bind to the scavenger receptor CD36[r]

investigation. Therefore, we evaluated tumor suppression role of TM in bladder cancer in the present study. The data obtained from cellular experiments using bladder cancer cell lines revealed that the expression of TM was inversely correlated with the invasive a[r]

Galectin-7 (Gal-7) is negatively regulated in cervical cancer, and appears to be a link between the apoptotic response triggered by cancer and the anti-tumoral activity of the immune system. Our understanding of how cervical cancer cells and their molecular networks adapt in response to the expressi[r]

Analysis of RNA expression for MMPs, TIMPs, and aggrecanases using RT-PCR
Using RT-PCR technology, we investigated the effect of selec- tive inhibition of TNF-α and/or IL-1 on MMPs, TIMPs, and ADAMTS metalloproteinases in the OA synov[r]

Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-inflammatory drugs (NSAIDs) as potential anti-tumor therapeutic agent is being evaluated glob[r]

The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancers but its role in malignant pleural tissue has yet to be established.

IL-6 triggers oncogenic/angiogenic signals and the cytokine-dependent pro-cachexia cascade. The prognostic role of the functional IL-6 (promoter) rs1800795 and the IL-6R (receptor) rs8192284 single nucleotide polymorphisms (SNP) was studied in patients with advanced gastric cancer treated with palli[r]

Brain levels of IL-1 β and IL-1ra were determined in frontal cortex using commercially available sandwich enzyme-linked immunosorbent assays (ELISA) (Rat IL-1 β /IL-1F2 and Human IL-1ra/IL-1F3 Quantikine ELISA Kits, respectivel[r]

The functional superiority of TLR7/8-activated IL-15 DCs over conventionally matured IL-15 DCs was evidenced by their _i _higher migratory potential, _ii _advantageous cytokine secretion[r]

Interleukin-22 (IL-22) is involved in lung diseases such as pneumonia, asthma and lung cancer. Lavage mirrors the local environment, and may provide insights into the presence and role of IL-22 in patients.