11 FUTURE POTENTIAL IN REGENERATIVE MEDICINE AND COMPARISONS TO HUMAN EMBRYONIC STEM CELLS

Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs.

(See figure on previous page.)
Figure 1 HNSCC cell lines contain cell populations with low proteasome activity and higher sphere-forming capacity. HNSCC cell lines were engineered to express the fusion protein ZsGreen and the c-terminal of the degron ornithine decarboxylase (c[r]

BIO-RAIDs is a prospective European study, involving oncology centers from France, Germany, Serbia, the Netherlands, Romania and Moldova. 700 patients with previously untreated, advanced stage CC (stage IB2-IV) will be enrolled. The recommendations for standards of treatment by stage of disea[r]

While microRNA (miRNA) expression is known to be altered in a variety of human malignancies contributing to cancer development and progression, the potential role of miRNA dysregulation in malignant mast cell disease has not been previously explored.

Considering international interest in herbal medicine research on this underutilized plant as a source of bioactive chemicals was carried out with the objective of evaluating its potential antibiotic activities to make a diagnosis of the chemistry related to the plant extract of E. variegata in orde[r]

Knowledge about signaling pathways in malignant cells may provide prognostic and diagnostic information in addition to identify potential molecular targets for therapy. B-cell receptor (BCR) and co-receptor CD40 signaling is essential for normal B cells, and there is increasing evidence that signali[r]

transformed cells, and are alternatively and/or coordi- nately expressed in several cancers, raising the possibility that a feedback loop might exist in this network [40-44].
It is well established that activation of the STAT3 sig- naling pathway promotes tumor[r]

Emerging evidence indicates that inappropriate cell-cell fusion might contribute to cancer progression. Similarly, mesenchymal stem cells (MSCs) can also fuse with other cells spontaneously and capable of adopting the phenotype of other cells. The aim of our study was to investigate the role of MSCs[r]

detected this phenomenon in MDA-MB-231, an ER- negative BC cell line (Additional file 1: Figure S3).
Activation of YB-1 suppresses Sox2 expression
To address if YB-1 activation, as evidenced by phosphor- ylation at its serine-102 residue [31,32], modulates Sox2 expression, we treat[r]

The cancer stem cells (CSCs), a small subpopulation of cells in tumor are responsible for the tumor initiation, growth, recurrence and metastasis of cancer, as well as resistance of cancers to drugs or radiotherapy. CSCs are an important target for the development of novel strategies in cancer treat[r]

MicroRNAs have recently succeeded in grabbing the center stage in cancer research for their potential to regulate vital cellular process like cell cycle, stem cell renewal and epithelial mesenchymal transition. Breast cancer is the second most leading cause of cancer related mortality in women.

Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This study analyzed the DNA damage response following ionizing radiation (IR) in 10 GSC lines der[r]

Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this study, we focused on the evaluation of the[r]

Talin-1 (TLN-1) and TLN-2 are implicated in many cellular processes, but their roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to assess cell cycle distribution, anoikis, invasion and migration in human HCC MHCC-97 L cells.

The presence of tumor supporting cells in various cancer, including in hepatocellular carcinoma (HCC), has become an important target in the study of carcinogenesis. The cancer-associated fibroblast (CAF), one of the most important cellular components in the cancer stroma, might contribute to the pr[r]

Insinuate perineural invasion and distant metastasis are characteristic of clinical features of ACC, and are the major challenge to very poor long-term outcome of patients with this disease [1,2,4]. Studies over more than 40 years revealed mounting evidence implicating matrix me[r]

Like normal hematopoietic stem cells, leukemia cells proliferate in bone marrow, where oxygen supply is limited. However, the growth and energy metabolism of leukemia cells under hypoxia have not been well understood.

Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion.

Germ cell neoplasia in situ (GCNIS), is preinvasive stage of testicular germ cell tumours (TGCTs). Fibrillins, which are integral components of microfibrils are suggested to be involved in cancer pathogenesis and maintenance of embryonic stem cells pluripotency. The aim of this study was to examine[r]

Recently, the cancer stem cell hypothesis has become widely accepted. Cancer stem cells are thought to possess the ability to undergo self-renewal and differentiation, similar to normal stem cells. Nucleostemin (NS), initially cloned from rat neural stem cells, binds to various proteins, including p[r]