treatment has the potential to cause harm, and treatment may be given that produces toxicity with no benefit. The therapeutic index of many interventions is quite narrow, and most treatments are given to the point of toxicity. Conv[r]
hypermutations in favor of A G transitions, by increas- ing the intracellular ratio of dCTP/dTTP.[27] An alternative important cause of G A hypermutation may involve a cellular factor, APOBEC3G, a cytidine deaminase that converts cytosine to uracil. The activity of<[r]
ter of the universe is in motion seems to take us beyond mere extension in three dimensions (see *Cartesianism)— something which leads Descartes to invoke the power of the Deity: ‘in the beginning God created matter, along with its motion and rest, and now . . . he cons[r]
Drug toxicities did not appear to have a significant impact on median MHS scores over the first 48 weeks of HAART. The 11 participants with drug toxicity had a lower median MHS score pre-HAART than the 281 participants without drug toxicity, but this difference was not statistically sig- nifi[r]
Secondary prophylaxis refers to the administration of CSFs in patients who have experienced a neutropenic complication from a prior cycle of chemotherapy; dose reduction or delay may be a reasonably considered alternative. G-CSF or GM-CSF is conventionally started 24–72[r]
2. Autologous T cells are removed from the tumor-bearing host, manipulated in several ways in vitro, and given back to the patient. The two major classes of autologous T cell manipulation are (a) to develop tumor antigen–specific T cells and expand them to l[r]
metabolism or excretion into the bile. This elimination in intestine and liver, which reduces the amount of drug delivered to the systemic circulation, is termed presystemic elimination , or first-pass elimination . Drug movement across the membrane of a[r]
The antitumor therapeutic potential of type III IFN gene transfer into experimental tumors was further evaluated in animal models by another research group using various approaches, comprising both the use of genetically modified cells and in vivo delivery of type II[r]
) white blood cell count (WBC) Infection parameters are sensitive but not specific These inflammation markers are sensitive but non-specific and are more helpful in terms of the temporal course rather than as absolute (single) values. The parameters can reliably be used to monitor[r]
He led the creation of the _Princeton Principles on Universal Jurisdiction_5 and co-authored the United Nations _Basic Principles and Guidelines on the Right to a Remedy and_ _Reparation[r]
References 1. Dean GL, Edwards SG, Ives NJ, Matthews G, Fox EF, Navaratne L, Fisher M, Taylor GP, Miller R, Taylor CB, de Ruiter A, Pozniac AL: Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapy. AIDS 2002, 16(1):[r]
Antithrombotic Drugs Antiplatelet drugs are the drugs of choice for prevention and treatment of arterial thrombosis. Anticoagulants are the drugs of choice for prevention and treatment of venous thromboembolism and...
Adherence to antiretroviral therapy (ART) in children is complicated may be because of many factors such as child characteristics, caregiver and family characteristics, regimen characteristics, etc.
In adults, most dental compensations, functional problems and facial deformities are already in development. There are some options of treatment that have been reported. Previously, some authors advocated that corrective surgery could be deferred until growth was complete; th[r]
least 30 days should be allowed to avoid interference in the response to one or another of the administered vaccine strains. Because high doses of immune globulin can inhibit the efficacy of measles and rubella vaccines, an interval of a[r]
Treatment B1 increased the value of Neutrophils by 83.7% compared to the comparison treatment (0.0). B1M showed the highest increase in Basophils values of 41.26% followed by treatment of B1A and B1MA increased by 38.09% and 34.92%. Treatment B1A showed the highest increase in Eosinophils values by[r]
Targeted trainings were also provided on the basis of weaknesses identified via pre- and post-test evaluations and in-service support and supervision visits. These cov- ered specific issues, such as drug management, monitor- ing and evaluation, laboratory investi[r]
The enormosity of infectious diseases continues to be a major constraint to the economical viability of livestock industry. Combined vaccines against more than one infectious disease reduce the cost, time, and labour of vaccination. In present study, formalized vaccines against Haemorrhagic Septicae[r]
to immunize children 6 months to 5 years of age with influenza vaccine and to expand routine use of the vaccine for their household contacts and out-of-home caregivers; to administer Tdap to protect health care personnel from pertu[r]
Objectives: To study prevalence of drug resistance and genotype testing for drug resistance HIV on HIV/AIDS patients with first-line antiretroviral treatment failure at Dongda Hospital, Hanoi. Subjects and methods: Cross-sectional, descriptive, prospective study on 47 HIV/AIDS patients with first-li[r]