CURRENT TREATMENT OPTIONS FOR METASTATIC HEAD AND NECK CANCER

Dysphagia or difficulty in swallowing affects quality of life for most patients with head and neck cancer. SIP SMART – [Swallowing Intervention Package: Self-Monitoring, Assessment, Rehabilitation Training] aims to improve post-treatment swallowing outcomes through a targeted and tailored pre-treatm[r]

Drugs for Psoriasis
Mild to moderate psoriasis is generally treated with topical corticosteroids. Vitamin D analogs and tazarotene are topical alternatives that can be used in combination with topical...
Nivolumab (Opdivo) for Metastatic Melanoma and Metastatic NSCLC
The FDA has approved nivoluma[r]

Head and Neck cancer (HNC) is characterized by significant mortality and morbidity. Treatment is often invasive and interferes with vital functions, resulting in a delicate balance between survival benefit and deterioration in quality of life (QoL).

Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-receptors, inhibiting development of new blood vessels.

Modified docetaxel, cisplatin, and 5-fluorouracil (mDCF) regimen has become a new standard for the treatment of metastatic or unresectable locally advanced recurrent squamous cell carcinoma of the anus (SCCA) after demonstrating improved efficacy (12-month PFS of 47%) in the Epitopes-HPV02 trial.

Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of metastatic PNEC with multiple visceral and subcutaneous secondary lesions, focusing on the[r]

Two New GLP-1 Receptor Agonists for Diabetes
Two new injectable GLP-1 (glucagon-like peptide-1) receptor agonists, dulaglutide (Trulicity [trū li si tee] – Lilly) and albiglutide (Tanzeum [tan'' zee um] – GSK), have been...
A Combination of Ledipasvir and Sofosbuvir (Harvoni) for Hepatitis C
The[r]

Insulin Degludec (Tresiba) - A New Long-Acting Insulin for Diabetes
The FDA has approved insulin degludec (Tresiba – Novo Nordisk) for treatment of adults with type 1 or type 2 diabetes. Insulin degludec is the third long-acting human insulin analog to...
Drugs Past Their Expiration Date
Healthca[r]

We investigated whether head and neck squamous cell carcinoma (HNSCC) patient-derived xenografts (PDXs) reaffirm patient responses to anti-cancer therapeutics.

chemotherapeutic drug is independent of freeradical action; antioxidants help maintain thehealth of normal tissues and protect them fromthe toxic effects of free radical–producingcytokines that circulate in cancer patients andincrease with the severity of the disease(Sozen et al., 2004[r]

.. .DELIVERY OF PROAPOPTOTIC BIOMOLECULES AND DRUGS USING AMPHIPHILIC BLOCK COPOLYMER NANOPARTICLES FOR ANTI- CANCER THERAPY ASHLYNN LINGZHI LEE (B.Eng (Chemical), Hons., NUS) A THESIS SUBMITTED FOR. .. fabricated and used for the codelivery of various anti- cancer drugs and therapeutic proteins for[r]

Colon adenocarcinoma (COAD) is one of the most lethal cancers. It is particularly important to accurately predict prognosis and to provide individualized treatment. Several lines of evidence suggest that genetic factors and clinicopathological characteristics are related to cancer onset and progress[r]

: Patients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2–3 years. A subgroup of those patients with mCRPC presents with oligoprogressive disease.

Mucinous adenocarcinoma (MAC) is a distinct type of colorectal cancer (CRC) associated with poor response to treatment and poorer prognosis. MAC is diagnosed by WHO definition when the extracellular mucin is more than 50% of the lesion.

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients with HCC show reduced sensitivity to sorafenib during treatment.

A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying chemotherapy resistance will improve treatment efficacy through genetic testing and nov[r]

Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previous studies have linked chromosomal instability (CIN), which generates aneuploidy following[r]

The Clever Crocodile SongI’m a clever crocodile, I run, I swim, I smile,This is my head, my ear, my tooth,My neck, my tummy, my back,I’m a clever crocodile, I run, I swim, I smile.Bugs World 2, MacmillanThe Clever Crocodile SongI’m a clever crocodile, I run, I swim, I smile,This is my[r]

In Brief: Generic Celecoxib
The FDA has authorized two manufacturers (Teva, Mylan) to market generic formulations of celecoxib (Celebrex – Pfizer), the only COX-2 selective inhibitor remaining on the US market....
Extended-Release Oxycodone and Acetaminophen (Xartemis XR)
The FDA has approved a f[r]

Although cancer-related fatigue (CRF) has gained increased attention in the past decade, therapy remains a challenge. Treatment programs are more likely to be effective if the needs and interests of the persons involved are well represented.