A NOVEL CONCEPT IN INNATE RESPONSES TO VIRAL INFECTION

by addressing the classical roles of peripheral innate immune cells including macrophages anddendritic cells, which seem to define the edges of this continuum. We then discuss various typesof microglial stimulation, including Toll-like receptor engagement by pathogen-associatedmolecula[r]

The high incidence of breast cancer has sparked the development of novel targeted and personalized therapies. Personalization of cancer treatment requires reliable prediction of chemotherapy responses in individual patients.

13. Glick M, Cleveland DB, Salkin LM, Alfaro-Miranda M, Fielding AF:Intraoral cytomegalovirus lesion and HIV-associated perio-dontitis in a patient with acquired immunodeficiency syn-drome. Oral Surg Oral Med Oral Pathol 1991, 72:716-720.14. Chee MS, Bankier AT, Beck S, Bohni R, Brown[r]

transcytosis. J Clin Invest 1994, 93:247-255.64. Hallett MB: The Neutrophil : cellular biochemistry andphysiology. Boca Raton, Fla., CRC Press; 1989:266. 65. Owen CA, Campbell MA, Boukedes SS, Campbell EJ: Cytokinesregulate membrane-bound leukocyte elastase on neu-trophils: a novel mec[r]

dt ky − uv,1.12 Boundary Value Problemswhere susceptible cells xt are produced at a constant rate λ, die at a density-dependentrate dx, and become infected with a rate βuv; infected cells yt are produced at rate βuvand die at a density-dependent rate ay; free v[r]

Denmark has a population of 5.4 million [8] with an estimated HCV prevalence of0.3% [9]. Treatment of HCV-infected patients takes place in hospital departmentsspecialised in infectious diseases, gastroenterology or hepatology [10]. Althoughmedical care, including antiviral treat[r]

48. Zhang J, Yamada O, Sakamoto T, Yoshida H, Iwai T, Matsushita Y, Shi-mamura H, Araki H, Shimotohno K: Down-regulation of viral rep-lication by adenoviral-mediated expression of siRNA againstcellular cofactors for hepatitis C virus. Virology 2004,320:135-143.49. Kronke J, Kittler R, Buchhol[r]

When semantically indexed texts are probed with asingle query, exercise, the ranking result is expectedto be the same as the order of the relevance score to thegeneral topic exercise, which was rated by subjects.Table 4 lists the weight comparison to the indexterm exercise of five texts[r]

associated with different risk groups. J Acquir Immune Defic Syndr 2002,29:422-426.56. Petroni A, Deluchi G, Pryluka D, Rotryng F, Bortolozzi R, Lopardo G,Bouzas MB, Zapiola I, Garone D, Rodriguez C, Chiocconi E, Lazaro ME,Murano F, Maranzana A, Oliva SM, Aparicio M, Beltran M, Benetuc[r]

therapeutic potential as a sequence specific inhibitor of viral infection. Here, we examine the abilityof exogenous small interfering RNAs (siRNAs) to block the replication of West Nile virus in humancells.Results: WNV replication and infection was greatly r[r]

directly assess the role of NE in reovirus infection of U937 cells, we examined viral growth in thepresence of N-Ala-Ala-Pro-Val chloromethylketone, a NE-specific inhibitor. Reovirus replication inthe presence of E64 was significantly reduced by treatment of cells[r]

15. Lindqvist M, Navabi N, Jansson M, Samuelson E, Sjoling A, Orndal C,Harandi AM: Local cytokine and inflammatory responses to candidatevaginal adjuvants in mice. Vaccine 2009, 28:270-278.Wahren et al . Journal of Translational Medicine 2010, 8:72http://www.translational[r]

tagged LCMV-specific cytotoxic T lymphocytes (CTL) progressively lost function; however, theseverity of this loss in the CNS was never as substantial as that observed in the periphery. One ofthe most impressive features of this model system is that the peripheral T cell response eventu[r]

B-DNA induces inflammatory mediator production byprimary murine microglia and astrocytesTo begin to deter mine whether DAI is functiona l in glialcells, we have assessed the sensitivity of cultured astrocytesand microglia to intracellular administration of poly(dA:dT) double str[r]

has an essential role in maintaining a highly regulatedmicroenvironment for the proper neuronal functioning.The BBB is composed of astrocytic foot processes,endothelial cells, and their associated basement mem-branes [44]. Importantly, the receptor for LCMV clone 13,α-dystroglycan [45][r]

Cyclophosphamide treatment on a six-day repeating metronomic schedule induces a dramatic, innate immune cell-dependent regression of implanted gliomas. However, little is known about the underlying mechanisms whereby metronomic cyclophosphamide induces innate immune cell mobilization and recruitment[r]

65-day observation period with no evidence of viral infection although the immunocompetent micedeveloped cellular and humoral immunity to HSV-1. In contrast, BALB/c scid recipients of gangliacontaining reactivating virus invariably developed a local and, subsequent[r]

65-day observation period with no evidence of viral infection although the immunocompetent micedeveloped cellular and humoral immunity to HSV-1. In contrast, BALB/c scid recipients of gangliacontaining reactivating virus invariably developed a local and, subsequent[r]

A wide range of studies has investigated the diagnostic proficiency of extracellular microRNAs (miRNAs) in hepatocellular cancer (HCC). HCC is expected to increase in Sub-Saharan Africa (SSA), due to endemic levels of viral infection (HBV/HIV), ageing and changing lifestyles.

This study was designed to investigate the impact of liver cirrhosis due to chronic hepatitis C virus (HCV) infection on the disease-free and overall survival of ovarian cancer patients undergoing a standard primary operation followed by standard chemotherapy.