INSULIN-LIKE GROWTH FACTOR-2

Over-expression of insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Previous studies examining other cancer types have implicated IMP3 in the regulation of several cellular functions that are characteristic of tu[r]

Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investigate if the insulin-like growth factor-1 receptor (IGF1R) signaling pathway was activated or[r]

Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis.

Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated outcomes and survival, although its effects on IGF´s are not well understood.

TRANG 1 NỒNG ĐỘ HÓC MÔN “INSULIN-LIKE GROWTH FACTOR-I /IGF-I” HUYẾT THANH Ở TRẺ EM VIỆT NAM - LỨA TUỔI TIỀN HỌC Đ−ỜNG NGUYỄN XUÂN NINH _Khoa Vi chất dinh d−ỡng - Viện Dinh D−ỡng _ Nghiên[r]

TRANG 1 CHARACTERISTICS OF BINDING OF INSULIN-LIKE GROWTH FACTOR IGF-I AND IGF-II ANALOGUES TO THE TYPE 1 IGF RECEPTOR DETERMINED BY BIACORE ANALYSIS CORRELATION OF BINDING AF®NITY WITH [r]

Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibition of IGF-1R results in growth inhibition and ap[r]

Renal cell carcinoma (RCC) incidence is highest in highly developed countries and it is the seventh most common neoplasm diagnosed. RCC management include nephrectomy and targeted therapies. Type 1 insulin-like growth factor (IGF-1) pathway plays an important role in cell proliferation and apoptosis[r]

IN THIS STUDY, WE TAKE THE FIRST STEP TOWARD DEVELOPING A RELATIVE INDEX OF BODY GROWTH FOR LINGCOD_OPHIODON ELONGATUS_USING PLASMA INSULIN-LIKE GROWTH FACTOR 1 IGF1 WITH THE ULTIMATE GO[r]

A number of clinical investigations have evaluated the interaction between HS [10], inflammation [11], and the IGF-I pathway; however, considering the effect of aging on IGF-I status and[r]

Results:Compared with young controls, untreated old rats showed an increase of oxidative damage in isolated mitochondria with a dysfunction characterized by: reduction of mitochondrial m[r]

Prostate cancer (PCa) is characterized by clinical and biological heterogeneity and has differential outcomes and mortality rates. Therefore, it is necessary to identify molecular alterations to define new therapeutic strategies based on the risk of progression.

TRANG 1 PEPTIDE REGULATES ADULT DEVELOPMENT OF THE SILKMOTH BOMBYX MORI Naoki Okamoto1, Naoki Yamanaka2,*, Honoo Satake3, Hironao Saegusa1,, Hiroshi Kataoka2and Akira Mizoguchi1 1 Divisi[r]

Cancer metastasis is the main contributor to breast cancer fatalities as women with the metastatic disease have poorer survival outcomes than women with localised breast cancers. There is an urgent need to develop appropriate prognostic methods to stratify patients based on the propensities of their[r]

Results:Compared with young controls, untreated old rats showed an increase of oxidative damage in isolated mitochondria with a dysfunction characterized by: reduction of mitochondrial m[r]

About the biological role, notwithstanding the very high expression of IGF1R in GIST carrying a wild type KIT and PDGFRA status, suggesting a possible role as a therapeutic target, almos[r]

TRANG 1 SIALIDASE NEU2 EXPRESSION DURING MYOBLAST DIFFERENTIATION AND HYPERTROPHY Alessandro Fanzani, Francesca Colombo, Roberta Giuliani, Augusto Preti and Sergio Marchesini Department [r]

Gene Igf2 (Insulin-like growth factor 2) là gene in dấu, chỉ biểu hiện trên allele có nguồn gốc từ cá thể đực (bố). Nó giữ nhiều chức năng quan trọng, cơ chế kiểm soát biểu hiện của gene Igf2 khá phức tạp và được điều khiển trực tiếp bởi các promoter.

Tần số kiểu gen và alen tại các điểm đa hình này tuân theo định luật cân bằng Hardy-Weinberg Đây là tiền đề để phát triển các nghiên cứu sâu hơn về ảnh hưởng đa hình di truyền lên các tí[r]

A number of clinical investigations have evaluated the interaction between HS [10], inflammation [11], and the IGF-I pathway; however, considering the effect of aging on IGF-I status and[r]