SURFACE WATER ADHESION MOLECULE

Colorectal cancer (CRC) is among the five most frequent causes for cancer-related deaths in Europe. One of the most important tumor-associated antigens for CRC is carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), which is involved in cell adhesion, migration, anoikis, tumor invasi[r]

http://www.translational-medicine.com/content/9/1/58Page 6 of 726. Siao CJ, Fernandez SR, Tsirka SE: Cell type-specific roles for tissueplasminogen activator released by neurons or microglia after excitotoxicinjury. J Neurosci 2003, 23:3234-3242.27. Flavin MP, Zhao G, Ho LT: Microglial tissue plasmi[r]

tochondrial PTP opening and cardiomyocyte hypercon-tracture. Several hours after the onset of myocardial re-perfusion, neutrophils accumulate in the infarcted myocardial tissue in response to the release of the che-moattractants (ROS, cytokines, and the activated com-plement). The up-regulated cell-[r]

Increased expression of METCAM/MUC18, a trans-membrane cell adhesion molecule in the Ig-like gene superfamily, has been associated with the malignant progression of epithelial ovarian carcinomas.

associated with functional outcome after ischemic stroke. Our aim was to study whether neuroserpin serum levelscould be associated to biomarkers of excitotoxicity, inflammation and blood brain barrier disruption.Methods: We prospectively included 129 patients with ischemic stroke (58.1% male; mean a[r]

Regulated intramembrane proteolysis of Epithelial cell adhesion molecule (EpCAM) results in release of its intracellular domain (Ep-ICD) which triggers oncogenic signalling. The clinical significance of Ep-ICD in breast cancer remains to be determined.

L1 cell adhesion molecule (L1CAM) overexpression has been reported to be strongly associated with poor prognosis in early stage endometrial cancer (EC). We aimed at the validation of L1CAM as a marker of poor prognosis in an independent study population.

(VCAM-1)-derived reactive oxygen species (ROS) in controllingtransendothelial migration (TEM). According to one model (Fig. 2A),VCAM-1 activates NADPH oxidase 2 (NOX2), which resides in theplasma membrane, in a Rac1-dependent manner. Extracellularlyproduced ROS activate metalloproteases, which degra[r]

The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-tomesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet its role in epithelial ovarian cancer (EOC) progression.

intercellular adhesion molecule-1 and vascular celladhesion molecule-1, is believed to be required for theinitiation of endothelial signaling. Both intracellularcalcium and the actin cytoskeleton, but also smallGTPases, reactive oxygen species and protein kinases,are involved in[r]

In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phenotype.

N-cadherin is a trans-membrane adhesion molecule associated with advanced carcinoma progression and poor prognosis. The effect of N-cadherin on matrix metalloproteinase 9 (MMP-9) regulation is implicated in human nasopharyngeal carcinoma (NPC) cell invasion.

The endothelial adhesion molecule, vascular adhesion protein-1 (VAP-1, AOC3) promotes lymphocyte recruitment to tumours, although the contribution that VAP-1 makes to lymphocyte recruitment in human colorectal cancer (CRC) is unknown.

Adhesion properties of adhesion-regulating molecule 1protein on endothelial cellsNathalie Lamerant and Claudine KiedaCentre de Biophysique Mole´culaire, CNRS UPR, Orle´ans Cedex, FranceTo fight infection, lymphocytes must continuously cir-culate through the body to maximize the o[r]

and improve central axonal sprouting in the facialmotor nucleus model [87], enhance functional recoveryafter spinal cord injury [106], but eliminate the condi-tional injury-induced spinal axon regeneration [107].While both BDNF and GDNF are robustly andreliably induced in the distal portion of the i[r]

able to interact with many CD98 molecules.If there is an association between CD98 and galec-tin 3, then disturbing it should disrupt cellular fusion.Indeed, by blocking galectin 3 CDR sites with 50 mmLac, we showed that we could reduce the fusion ofBeWo cells.Getting proteins to the correct place at[r]

␮m) are desir-able in order to obtain higher sensitivity. Consequently, thesemicrocantilevers are often very slender and compliant, vul-nerable to external forces during fabrication processes in-cluding final steps of releasing, handling, and device opera-tion. For instance, thermal stresses, surf[r]

dent, because the cell adhesion properties of syndecansare not only limited to the HS chains, but can also bemediated through the ectodomain core protein. Theevolutionarily conserved NXIP motif of syndecan-4has been shown to promote b1-integrin-dependent celladhesion [89]. Syndecan-1 ectodoma[r]

tity in shape of the spectra of the HlyA monomer and theoligomer (Fig. 3A) and the similarity in quenching charac-teristics of the two proteins indicated that the two toxinforms shared similar global conformations. Nevertheless,the HlyA monomer and the oligomer could be distinguishedby ANS. Although[r]