BÁO CÁO Y HỌC: ": DIFFERENTIAL SPLICING OF THE APOPTOSIS-ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE RECRUITMENT DOMAIN (ASC) REGULATES INFLAMMASOMES" DOC
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and persisted for more than 24 hr. This information provided a novel insight into the mechanisms of action of ethanol (1mM) in human hepatocellular carcinoma cells. Key words: Ethanol, HepG2 cells, protein kinases, signal transduction, transcription factors, gene expression 1. Introduction Ap[r]
date the mechanism of this network. However, a poor correlation between mRNA and protein abundance has also been reported [9]. Furthermore, a single gene can encode for more than one mRNA species through differential splicing, and proteins can undergo as many as 200 posttranslational m[r]
sity and is influenced by genetic and environmental factors, and in particular, changes in diet and physical activity [8,9]. Lipid abnormalities associated with obe-sity include increased overall production of lipids with elevated concentrations of fatty acids, triacyl-glycerols, and low-density lip[r]
nate length of time for widespread realization, it is now generally recognized that overweight/obesity have reached epidemic proportions in the United States [11]. Further, this health problem is not limited to America, because globally there are over one billion overweight adults according to many[r]
relatively similar pattern to that found in the untreated control cells. The pairwise comparison analysis demonstrated four significantly up-regulated (COBRA1, ITGB4, STAU2, and HMGN3) genes and one down-regulated (ANK3) gene. All these genes exert their function on transcriptional and translational[r]
glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrop[r]
A group of 16 females, aged 80-93 years old, was divided into 2 groups according to their baseline DHEA-S lev-els: Lower Halves (N = 8) and Upper Halves (N = 8), and participated in a 4-month exercise intervention trial. Insulin response with an oral glucose tolerance test (OGTT), chol[r]
pattern. It is possible that participants who have been diagnosed with a chronic disease may have changed their diet. To address this concern we adjusted for the presence of chronic disease (CHD, cancer, and stroke) and hypertension throughout the analyses. We also repeated the analyses exclu[r]
past decade. Where on one hand, this treatment has proven its effectiveness in ideal population; it has also identified some special populations by way of poor response or difficulties faced due to co morbid conditions. These special populations include patients with cirrhosis, non responders to pri[r]
As an example we presented the finding that maternal use of loratadine in early pregnancy was associated with a roughly doubled risk for infant hypospadias. We concluded: “The finding can still be random, but causality cannot be dismissed, even though the mechanism of action is not understood[r]
of wild type BRCA1 and BRCA2, DSBs can be efficiently repaired by RAD51 mediated homologous recombination (Fig. 1B). It has been shown that BRCA1 and BRCA2 interact with RAD51, and play essential role in homologous recombination [28, 30, 31]. Thus, in the event of DNA damage associated with PARP inh[r]
which is the final irreversible stage characterized by parenchymal nodules with encircling fibrous septa. The hepatitis C virus is not considered to directly injure the liver but it rather triggers an HCV-specific lymphoproliferation. Through profuse cytokine production and also a direct cyto[r]
margins is of paramount importance and that histological factors have an inconsistent influence on biologic behavior [3]. Sarcomatous stromal elements, including angiosarcoma, chondrosarcoma, leiomyosarcoma, osteosarcoma, and rhabdomyosarcoma, are rarely encountered in malignant phyllodes tumors [4][r]
the RM group (χ2=1.60, p=0.21). The genotypes of TNF-A T-1031C had no associations with the eradication rate. But among the RM group, the odd ratio (OR) of the TNF-A CT for the eradication rate relative to TT was marginally reduced (OR=0.05, 95% confidence interval, 0.002-1.19). Conclu[r]
3. Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Na-goya, 461-8673 Japan Correspondence to: Simon Itou, Department of Preventive Medicine / Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Ts[r]
Germany). HDL was measured following precipitation of apoB containing lipoproteins with phosphotungstate (Boehringer Mannheim). Apoliprotein AI (Apo AI) and Apo B were measured using the Beckmann Array 360 (Beckmann Instruments). Genotyping DNA was extracted from white blood cells using standard met[r]