DOES ANTIHYPERTENSIVE TREATMENT WITH RENIN-ANGIOTENSIN SYSTEM INHIBITORS PREVENT THE DEVELOPMENT OF DIABETIC KIDNEY DISEASE?

Although renin-angiotensin II-aldosterone system inhibitor (RASI) use for renal protection is welldocumented, adherence to RASI therapy in the pediatric population is unclear. This study aimed to evaluate patient characteristics associated with adherence to chronic RASI use in patients with childhoo[r]

Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side ef[r]

cells to T-cell receptor stimulation [43], earlier studies have questioned the impact of synovial T cells on the local inflammatory process. More recent reports have identified
‘ pro-inflammatory ’ Th1 and Th17 cells as well as ‘ anti- inflammatory ’ regulatory T cells (Treg[r]

Th e current fi ndings are of potential importance in our understanding of the role of circulating and tissue sources of ACE2, particularly in various disease states. Increased circulating levels of ACE2 may refl ect a compensatory mechanism to a[r]

To achieve this goal, the Kidney Disease Outcomes Quality Initiative K/DOQI working group of the National Kidney Foundation of the United States defined CKD as “evidence of structural or[r]

Immune checkpoint inhibitors are standard treatments for non-small cell lung cancer. Unique cases with paradoxical acceleration of the disease after immunotherapy have been reported. These have been described as cases of hyperprogressive disease.

In Kawasaki disease (KD), a vasculitis of unknown etiology, the most serious complication is the development of coronary artery aneurysm (CAA). To date, the exact pathomechanism of KD is unknown. Both environmental and genetic factors seem to be associated with the development of the disease.

The advent of tyrosine kinase inhibitors (TKIs) has changed the treatment of RAI refractory, unresectable recurrent differentiated thyroid cancer (DTC), which was formerly treated with multidisciplinary remedies.

Colorectal cancer (CRC) is a major health problem in developed countries. Adenomatous lesions in the large bowel are the main precursors of CRC and the adenoma-adenocarcinoma sequence still provides a solid model for research on carcinogenesis.

Besides the evaluation of the effects of different immuno- suppressive protocols on HRQL after transplantation, it is feasible to discuss the potential importance of HRQL eval- uations before transplantation and the probable implica- tion of[r]

For educational purposes for trainees it is very valu- able to include these scoring systems in the clinical assess- ment, but their limitations due to complexity must be acknowledged. In specialized centers, measurement of biochemical markers has become a standard for pro[r]

Several studies have indicated that triggering is more common in patients with known coro- nary artery disease than in those without it. 1,15,16 Our results are consistent with these findings: cardiovascular events on days of soccer matches with German participa[r]

The proteasome is a validated anti-cancer target and various small-molecule inhibitors are currently in clinical development or on the market. However, adverse events and resistance associated with those proteasome inhibitors indicate the need for a new generation of drugs.

Most rice growing areas frequently encounter the bacterial leaf blight, Xanthomonas oryzae pv oryzae (Xoo). To prevent the disease, development of resistant varieties is considered to be the most economical and environmentally safe solution.

Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating disease. The aim of this study was to evaluate hyperprogression in patients with malignant tu[r]

Recently, two randomised controlled trials have studied the effects of carvedilol, a â blocker with á blocking and vasodilator properties, in patients with symptomatic heart failure. The US multicentre carvedilol study programme was stopped early because of[r]

Despite an increase in the development of biological therapies for autoimmune disease (AID), a proportion of patients remain treatment refractory, resulting in long term morbidity and increased rates of mortality. Furthermore, maintenance biologic therapies are associated with treatment-related side[r]

(BQ) Part 2 book “ABC of kidney disease “ has contents: Chronic kidney disease, dialysis and transplantation in children, dialysis, conservative (‘non dialytic’) treatment for patients with chronic kidney disease, renal transplantation, the organization of services for people with chronic kidney di[r]

Nowadays there is a growing interest in exploring causes of fatigue symptoms and the possible linked aspects in patients with Chronic Kidney Disease (CKD) receiving hemodialysis (HD) treatment. Inflammatory processes were demonstrated to influence motivational systems functioning in chronic conditio[r]

On correlating indexed SBP to different cardiovascular risk markers by multiple linear regression analysis, we found that C-allele, serum urea, hs-CRP and CK-MB were variables that were independently associated with indexed SBP. In hypertensive patients it is suggested that the combination