BÁO CÁO Y HỌC: " APOPTOSIS OF VIRAL-INFECTED AIRWAY EPITHELIAL CELLS LIMIT VIRAL PRODUCTION AND IS ALTERED BY CORTICOSTEROID EXPOSURE" POT

Jamison K, Hawley-Foss N, Lynch DH, Badley AD: Induction of celldeath in human immunodeficiency virus-infected macro-phages and resting memory CD4 T cells by TRAIL/Apo2l. JVirol 2001, 75(22):11128-11136.23. Servet-Delprat C, Vidalain PO, Bausinger H, Manie S, Le De[r]

The F protein from the PIV5 strain WR, whichnormally requires the presence of an HN protein forfunction, can promote HN-independent membranefusion when present at elevated temperature [80], sug-gesting that the requirement for HN triggering of Fcan also be replaced by conditions[r]

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USAEmail: W James Cook - JCook@glycofi.com; Martha F Kramer - martha_kramer@hms.harvard.edu; Russell M Walker - Walker@mpi.com; Timothy J Burwell - Burwell@mpi.com; Holly A Holman - holmanholly[r]

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USAEmail: W James Cook - JCook@glycofi.com; Martha F Kramer - martha_kramer@hms.harvard.edu; Russell M Walker - Walker@mpi.com; Timothy J Burwell - Burwell@mpi.com; Holly A Holman - holmanholly[r]

of recurrence, the differences in survival were not significant; however, the shortfollow-up period was a problem. The conduct of a high-quality RCT that is ableto rigorously evaluate the outcome of RFA and liver resection is awaited in thefuture.The recommen[r]

adept at entering epithelial cells than are more virulent strains; examples include pathogens that lack the surface polysaccharide capsule needed to cause serious disease. Thus, for Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus agalactiae (group B Streptococcus), a[r]

been repeatedly verified, the cellular protein that is responsible for this binding has not been found yet. The limited availability of primary human tissue almost certainly hampers progress. Research has thus relied heavily upon human hepatoma cell lines [44]. Using a synthesized pept[r]

not a single new HCoV had been described. The genomefeatures of SARS-CoV and its transcription strategy havebeen described in detail [1,5,7]. Here, we present such ananalysis for HCoV-NL63.HCoV-NL63 is a member of the coronaviridae family thatclusters together with arteri[r]

4. Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL,Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE: Unique and con-served features of genome and proteome of SARS-coronavi-rus, an early split-off from the coronavirus group 2 lineage. JMol Biol 2003, 331:991-100[r]

programmed cell death 4 gene. Oncogene 2008, 27:4373-4379.23. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, et al:Circulating microRNAs as stable blood-based markers for cancerdetection. Proc Natl Acad Sci USA 2008, 105:105[r]

directly assess the role of NE in reovirus infection of U937 cells, we examined viral growth in thepresence of N-Ala-Ala-Pro-Val chloromethylketone, a NE-specific inhibitor. Reovirus replication inthe presence of E64 was significantly reduced by treat[r]

Konstantin G Kousoulas* - vtgusk@lsu.edu* Corresponding author AbstractBackground: The NV1020 oncolytic herpes simplex virus type-1 has shown significant promisefor the treatment of many different types of tumors in experimental animal models and humantrials. Previously, we desc[r]

tion with PacI (New England BioLabs, Bervery, MA, USA)and transfected into subconfluent 293A cells (Invitrogen)with Lipofectamine 2000 (Invitrogen) in Opti-MEM med-ium (Invitrogen). After 1–2 weeks of culture in RPMI-1640containing 10% fetal bovine serum until most cells h[r]

– ++– – – ++– ++– – α-Puma α−β-actinFig. 6. Knockdown of DNp63a expression cooperates with TNF-a treatment and induces expression of the proapoptotic gene Puma. (A)RNA was isolated from ME180 cells prepared as in Fig. 5, and real-time RT-PCR was performed for candi[r]

ml ARB. This was observed for HCVpp derived from twodifferent HCV genotype 1b isolates (AY734975 andAF333324). As a positive control, ARB also completelyinhibited the fusion of pseudoparticles bearing the influ-enza virus hemagglutinin (HA) protein (Fig. 5B). Theinhibition was observed immedi[r]

homologue for the enzyme, competing with eIF2α, and inhibiting the translational block. It has beenshown that during the interaction with PKR, Tat becomes phosphorylated at three residues: serine62, threonine 64 and serine 68. We have investigated the effect of this phosphorylat[r]

BioMed CentralPage 1 of 14(page number not for citation purposes)Virology JournalOpen AccessResearchNeutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cellsJoseph W Golden and Leslie A Schiff*Address: Depart[r]

J Biol Chem 1997, 272:8388-8395.23. Roy S, Katze MG, Parkin NT, Edery I, Hovanessian AG, Sonenberg N:Control of the interferon-induced 68-kilodalton proteinkinase by the HIV-1 tat gene product. Science 1990,247:1216-1219.24. Kao SY, Calmna AF, Luciw PA, Peterlin BM: Anti-termination of[r]

tor Labs, Burlingame, CA) also for 15 min. Monolayers ofHFF cells on coverslips were transfected with Lipo-fectamine 2000 according to the manufacturer's protocol(Invitrogen). Transfected cells were fixed and permeabi-lized by the same methods described above. Monoclonala[r]

the most widely used retroviral vector pseudotypes ingene therapy trials. Achievement of controlled but effi-cient gene delivery will, however, depend on a detailedinsight into virus biology. We have previously shown thatA-MLV entry is closely associated with cholesterol-richmicrodomai[r]