ANTI-HU ANTIBODY ASSOCIATED PARANEOPLASTIC CEREBELLAR DEGENERATION IN HEAD AND NECK CANCER

Paraneoplastic syndromes are most frequently associated with small cell lung carcinoma, hematologic and gynecologic malignancies while reports in head and neck cancer are rare. We present the case of a 60-year old female patient who developed paraneoplastic cerebellar degeneration upon locoregional[r]

In head and neck cancer little is known about the kinetics of osteopontin (OPN) expression after tumor resection. In this study we evaluated the time course of OPN plasma levels before and after surgery.

Head and neck cancer squamous cell carcinoma (HNSSC) patients report substantial rates of clinically significant depression and/or anxiety, with dysphagia being a predictor of distress and poorer quality of life. Evidence-based dysphagia interventions largely focus on the remediation of physical imp[r]

squamous cell cancer
Akhileshwar Namani 1 † , Md. Matiur Rahaman 2 † , Ming Chen 2* and Xiuwen Tang 1*
Abstract
Background: NRF2 is the key regulator of oxidative stress in normal cells and aberrant expression of the NRF2 pathway due to genetic alterations in[r]

Squamous cell carcinoma of the head and neck (SCCHN) remains a prevalent and devastating disease. Recently, there has been an increase in SCCHN cases that are associated with high-risk human papillomavirus (HPV) infection.

papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 12:701, 2006 [PMID: 16467079] Vokes E et al: Weekly carboplatin and paclitaxel followed by concomitant TFHX chemoradiotherapy: Curative and organ preserving therapy for a[r]

Human papillomavirus DNA detection in head and neck squamous cell carcinoma has been linked to improved patient prognosis. The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p53 function within tumours were associated with the widely reported improved patient surviva[r]

risk was observed in the analysis stratified by HNC sites or by the use of alcohol, betel quid, or cigarette.
To date, three studies have been published on the as- sociation between PA and HNC and the results have been inconsistent. Leitzmann et al. examined the associ- ation[r]

Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody used in association with chemothera[r]

Chapter 084. Head and Neck Cancer (Part 4) Table 84-2 Definition of TNM–Nasopharynx Primary Tumor (T) Stage Grouping TX Cannot be assessed Stage 0 Tis N0 M0 T0 No evidence Stage I T1 N0 M0 Tis Carcinoma in situ Stage IIA T2a N0 M0

Paraneoplastic neurological syndromes (PNS) are rare disorders associated with malignant tumours, which are triggered by autoimmune reactions. Paraneoplastic cerebellar degeneration (PCD) is the PNS type most commonly associated with ovarian and breast cancer.

The gene encoding fibroblast growth factor receptor 1 (FGFR1) is emerging as a therapeutic and prognostic biomarker in various cancer types, including head and neck squamous cell carcinoma (SCC).

Head and Neck cancer (HNC) is characterized by significant mortality and morbidity. Treatment is often invasive and interferes with vital functions, resulting in a delicate balance between survival benefit and deterioration in quality of life (QoL).

Pembrolizumab is an anti- Programmed Death 1 (PD-1) antibody approved in melanoma, non-small cell lung cancer and investigated in malignant pleural mesothelioma. The most frequent immunotherapy related autoimmune reactions include dermatitis, pneumonitis, colitis, hypophysitis, uveitis, hypothyreodi[r]

To evaluate the anticancer effect of measles vaccine virus in combination with Nimotuzumab in vitro. To evaluate the anticancer effect of measles vaccine virus in combination with Nimotuzumab on nude mouse model with head and neck cancer (in vivo).

• prompt treatment of mucositis symptoms and oral infections.Other Treatment OptionsIn addition to the use of an oral care protocol, the following interventions may offer some benefits. It should be noted that thesupport for some of these interventions is based on limited Level II evidence, <[r]

Induction chemotherapy incorporating docetaxel, cisplatin and 5- fluorouracil before radiotherapy may improve the outcome of patients with advanced head and neck cancer. Nevertheless, the addition of docetaxel increases hematological toxicity and infectious complications.

endoscopy or biopsy; these patients are considered to have carcinoma of unknown primary (Fig. 84-1). If the enlarged nodes are located in the upper neck and the tumor cells are of squamous cell histology, the malignancy probably arose from a mucosal surface in the head[r]

Anti-PD1 inhibitors have been approved for the treatment of recurrent or metastatic head and neck cancer (HNC), as a result of Global Phase III trials. However, the clinical outcomes of immune checkpoint inhibitors in patients who are not eligible for clinical trials or have various medical conditio[r]

The side population (SP) of cancer cells is reportedly enriched with cancer stem cells (CSCs), however, the functional role and clinical relevance of CSC marker molecules upregulated in the SP of head and neck squamous carcinoma (HNSCC) cells are yet to be elucidated.