INITIAL CHARACTERISATION OF EXOSOMES RELEASED BY UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS AND MATURE DENDRITIC CELLS, UNDER ‘GOOD MANUFACTURING PRACTICE’ CONDITIONS
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Initial characterisation of exosomes released by umbilical cord-derived mesenchymal stem cells and mature dendritic cells, under ‘Good Manufacturing Practice’ conditions
Exosomes represent an important mode of intercellular communication and play key roles in many physiological and pathological processes. Exosomes have hitherto exhibited their capacity to modulate biological activities through their carrying of functional molecules such as proteins, lipids, and gene[r]
BÁO CÁO Y HỌC: " HUMAN EMBRYONIC STEM CELL (HES) DERIVED DENDRITIC CELLS ARE FUNCTIONALLY NORMAL AND ARE SUSCEPTIBLE TO HIV-1 INFECTION" POT
In this regard, the ability to generate cells of the hemat- opoietic system has considerable potential in several areas of clinical and experimental medicine as they can recon- stitute the entire blood system and can serve as primary targets in gene therapy in trea[r]
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BÁO CÁO Y HỌC: " MOLECULAR MECHANISMS OF HIV-1 PERSISTENCE IN THE MONOCYTE-MACROPHAGE LINEAGE" PPT
In this review, we focus on the molecular mechanisms responsible for viral persistence in cells of the monocyte- macrophage lineage since they are believed to be an important source of HIV-1 [14,19]. Several features make cells from this lineage a potential HIV-1 reservoi[r]
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DISTINCT PROSTATE CANCER-RELATED MRNA CARGO IN EXTRACELLULAR VESICLE SUBSETS FROM PROSTATE CELL LINES
Multiple types of extracellular vesicles (EVs), including microvesicles (MVs) and exosomes (EXOs), are released by all cells constituting part of the cellular EV secretome. The bioactive cargo of EVs can be shuffled between cells and consists of lipids, metabolites, proteins, and nucleic acids, incl[r]
CHAPTER 068. HEMATOPOIETIC STEM CELLS (PART 3) PDF
In most tissues the proliferative cell population is a more immature progenitor population. In general, cells within the highly proliferative progenitor cell compartment are also relatively short-lived, making their way through the differentiation process in[r]
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Long-term expansion enhances the expression of tumor suppressor genes in human bone marrow-derived mesenchymal stem cells
Mesenchymal stem cells (MSCs) are possibly the most potent type of stem cells for the treatment of many diseases since they possess many advantageous properties, such as abundant source, ease of isolation, and potential to differentiate and trans-differentiate into different types of cells.
BÁO CÁO Y HỌC: " BET HEDGING IN THE UNDERWORLD" PDF
A further and related issue concerns the capacity for a developmentally controlled phenotypic switch to be tuned to prevailing environmental conditions. Simple models [8] predict that, in organisms capable of bet hedg- ing, the rate of switching between pheno[r]
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ADVANCES IN REGENERATIVE MEDICINE POT
4.1 Intramyocardial injection
Direct transplantation of HUCB stem cells into the myocardium of the infarcted heart has been widely investigated in in vivo studies due to the advantage that it provides a direct route to the damaged area. Hirata et al . showed the th[r]
Direct transplantation of HUCB stem cells into the myocardium of the infarcted heart has been widely investigated in in vivo studies due to the advantage that it provides a direct route to the damaged area. Hirata et al . showed the th[r]
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BÁO CÁO Y HỌC: "RELATIVE PERCENTAGE AND ZONAL DISTRIBUTION OF MESENCHYMAL PROGENITOR CELLS IN HUMAN OSTEOARTHRITIC AND NORMAL CARTILAGE" POTX
Conclusions
The present study suggests that CD166 is a suitable bio- marker for the identification and localization of resident MPCs with high chondrogenic potential in human articular cartilage. In addition, the percentage of MPCs in OA and normal cartilage is substant[r]
The present study suggests that CD166 is a suitable bio- marker for the identification and localization of resident MPCs with high chondrogenic potential in human articular cartilage. In addition, the percentage of MPCs in OA and normal cartilage is substant[r]
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Histological study on the changes of elastic fibers in localized scleroderma model in thin skin of adult male albino rat and the possible curative role of bone marrow-derived mesenchymal
Scleroderma is an autoimmune disease manifested by painful digital ulcers, joint contracture and skin thickening. Bone marrow-derived mesenchymal stem cells (BMMSCs) have become a recent focus of interest in tissue regeneration. The aim of this work was to study the changes of elastic fibers in loca[r]
Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment
Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The prese[r]
MOTILITY AND ALIGNMENT OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC) ON 3D SCAFFOLDS
TRANG 1 MOTILITY AND ALIGNMENT OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS HUVEC ON 3D SCAFFOLDS ZHENG ZHONG TRANG 2 MOTILITY AND ALIGNMENT OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS HUVEC [r]
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Nhận biết và nuôi cấy đơn dòng tế bào gốc phân lập từ nút phôi của túi phôi chuột
and long term culture of embryonic stem cells derived from inner cell mass of mouse blastocysts (Mus. musculus)[r]
Placenta-derived mesenchymal stem cells reduce the interleukin-5 level experimentally in children with asthma
Mesenchymal stem cells (MSCs) have been investigated as a new treatment option for various diseases in recent years. However, the role of placenta-derived MSCs in children with asthma remains unclear.
The release of tryptase from mast cells promote tumor cell metastasis via exosomes
Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown.
Reprogramming factors remodel melanoma cell phenotype by changing stat3 expression
The limited availability of melanoma stem cells is a major challenge for therapeutic reagent screening and study of molecular mechanisms. It has been shown that induced expression of four stem cell factors (Oct4, Sox2, Klf4, and c-Myc) changes the phenotype of osteosarcoma and breast cancer cells to[r]
MECHANISM OF RECIPIENT CELL-DEPENDENT DIFFERENCES IN EXOSOME UPTAKE
Exosomes, small-membrane vesicles, are secreted by cells and include several types of proteins and nucleic acids. Exosomes transfer cellular information derived from donor cells and are involved in various physiological and pathological events, such as organ-specific metastasis.
BÁO CÁO HÓA HỌC ADIPOSE DERIVED MESENCHYMAL STEM CELL PROTECTS KIDNEYS AGAINST ISCHEMIA REPERFUSION INJURY THROUGH SUPPRESSING OXIDATIVE STRESS AND INFLAMMATORY REACTION DOCX
Background: Reactive oxygen species are important mediators exerting toxic effects on various organs during ischemia-reperfusion (IR) injury. We hypothesized that adipose-derived mesenchymal stem cells (ADMSCs) protect the kidney against oxidative stress and inflam[r]
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IN VITRO DIFFERENTIATION OF STEM CELLS TOWARDS ISLET LIKE CELLS
Mesenchymal stem cells are multipotent non-hematopoietic progenitor cells that show the potential in treatment for autoimmune diseases because of their ability to differentiate along different lineages in addition to the low immunogenic potential and[r]
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Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis
The tumor microenvironment and its stromal cells play an important role in cancer development and metastasis. Bone marrow-derived cells (BMDCs), a rich source of hematopoietic and mesenchymal stem cells, putatively contribute to this tumoral stroma.