GENE EXPRESSION PROFILING LEADS TO DISCOVERY OF CORRELATION OF MATRIX METALLOPROTEINASE 11 AND HEPARANASE 2 IN BREAST CANCER PROGRESSION

Emerging technologies, such as gene expression profiling, are increasingly valued as powerful tools for new biomarker identification [20–24]. Data from gene expression profiling is generated from the analysis of hybridization microarray, which is a po[r]

Author details
1 Cancer Biology Lab, Institute of Life Sciences, Nalco Square,
Chandrasekharpur, Bhubaneswar, Odisha 751023, India. 2 Present address: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center (UNMC), Omaha,[r]

Most dietary tryptophan enters the kynurenine pathway,leading to the biosynthesis of NAD or resulting in thecomplete oxidation of amino acids for energy production.Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) can both function as the initi[r]

Long noncoding RNAs (lncRNAs) have been suggested to be involved in the development and progression of malignancies. However, the investigation of small nucleolar RNA host gene 20 (SNHG20) on cancer progression remains unknown.

against low-Nm23-expressing human breast carcinoma and melanoma cell lines.Nature Med. 3, 395–401 (1997).19. Koo, H M. et al. Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine andtopoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes.J. Nat[r]

Genomic DNA extraction, PCR (Polymerase Chain Reaction) amplification of the TP53 exons 2 – 11, and mutational analysis by direct sequencing
DNA extraction from formalin-fixed paraffin-embedded (FFPE) tissue samples on histological sections was per- formed. For microdis[r]

A capillary network is needed in cancer growth and metastasis. Induction of angiogenesis represents one of the major hallmarks of cancer. CDK11p58, a Ser/Thr kinase that belongs to the Cell Division Cycle 2-like 1 (CDC2L1) subfamily is associated with cell cycle progression, tumorigenesis, sister ch[r]

Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in pancreatic cancer models in vitro and in vivo.

Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. CNOB (3.3 mg/kg) was injected iv in mice implanted with humanized ChrR6 (HChrR6)-expressing 4T1 tumors.

Molecular characterization of circulating tumor cells (CTC) is promising for personalized medicine. We aimed to identify a CTC gene expression profile predicting outcome to first-line aromatase inhibitors in metastatic breast cancer (MBC) patients.

Due to lack of a targeted therapy for the triple-negative breast cancer (TNBC) patients, it is important to explore this aggressive breast cancer type in more detail and to establish novel therapeutic approaches. TNBC is defined negative for the protein expression of oestrogen receptor (ER), progest[r]

Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ESR2) and the androgen receptor gene (AR) with colorectal cancer risk and prognosis.

DOI:http://dx.doi.org/10.7314/APJCP.2014.15.22.9607BRCA1 Promoter Hypermethylation for Detection of Breast Cancer in Viet NamRESEARCH ARTICLEBRCA1 Promoter Hypermethylation Signature for EarlyDetection of Breast Cancer in the Vietnamese Populat[r]

H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression. Our findings point to epigenetic mark H3K27me3 as an important event in prostate carcinogenesis and progression. The results repo[r]

The origin and development of breast cancer remain complex and obscure. Recently, microRNA (miRNA) has been identified as an important regulator of the initiation and progression of breast cancer, and some studies have shown the essential role of miR-124-3p as a tumor suppressor in breast tumorigene[r]

have been used in Affymetrix RNA profiling studies (Mainz cohort) [19]. Results of immunostaining were assessed using an intensity score (IS: 0-3) and a proportion score (PS: 0-4). Intensity scores of 0-3 were observed for 18.1, 23.2, 33.7 and 24.9% of