BÁO CÁO Y HỌC: "IDENTIFICATION OF SECONDARY TARGETS OF N-CONTAINING BISPHOSPHONATES IN MAMMALIAN CELLS VIA PARALLEL COMPETITION ANALYSIS OF THE BARCODED YEAST DELETION COLLECTION" PPSX
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References 1. Minella AC, Clurman BE. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle. 2005;4(10):1356-9. 2. Fuchs SY. Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor. Cancer Biol Ther. 2005;4(5):506-8. 3. Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed[r]
Figure 1 shows the hierarchical gene expression profile of 1 mM ethanol concentration treated HepG2 cells (group 1) and control cells (HepG2 cells without treatment; group 2) exposed for a 6 h period. Data are presented as a median of the signal obtained from the six different microarrays for each g[r]
The PTPN11 polymorphism was associated with gastric atrophy among seropositive subjects [18]. The two tyrosine residues (Tyr-627 and Tyr-659) in the carboxyl-terminal region of Gab1 are required for SHP-2 binding to Gab1 and for EGF-stimulated ERK activation, in which another study reported Gab1/SHP[r]
separation. An aliquot of the sorted cells was then analyzed by flow cytometry (FACSCalibur, Becton Dickinson, San Jose, CA) to verify the phenotype in each subset. The cells were analyzed using FlowJo software (Tree Star Inc, San Jose, CA) following stain-ing with the following antibodies (BD Biosc[r]
control cells. All points were done duplicate X three times, and the results are average +/- SD. “* “means p<0.05, and “n.s”: means statistically not sig-nificant. Altered expression of apoptosis-related proteins by hypoxia in the JAR cell line demonstrated using the PowerBlot Wester[r]
References 1. Labenz J, Borsch G. Evidence for the essential role of Helicobacter pylori in gastric ulcer disease. Gut. 1994; 35: 19-22. 2. IARC. Infection with Helicobacter pylori. In: IARC monographs on the evaluation of the carcinogenic risks to humans. Lyon, France: International Agency for Rese[r]
4. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology 1998;27:1435-1440. 5. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, Urushihara A, Ki[r]
and found similar trends. Thus, in this paper we present results that include all self-reported cases of type 2 DM. We excluded women from the current Int. J. Med. Sci. 2006, 3 154analysis who had diabetes or had a positive urinary glucose test at the baseline survey. The total follow-up was 4.6 ye[r]
and basal core promoter mutations on viral replicative interference. Hepatology 2001;34:404-410. 41. Crespo J, Lozano JL, Carte B, de las Heras B, de la Cruz F, Pons-Romero F. Viral replication in patients with concomitant hepatitis B and C virus infections. Eur J Clin Microbiol Infect Dis 1997;16:4[r]
and severity of disease. Am J Gastroenterol 2001; 96:2957. 10. Pagano G, Pacini G, Musso G, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association. Hepatology 2002; 35:367. 11. Marchesini G, Brizi M, Morselli-Labate AM, et al. A[r]
association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology 2002;122:889-96. 10. Berenguer M, Prieto M, San Juan F, Rayon JM, Martinez F, Carrasco D, Moya A, Orbis F, Mir J, Berenguer J. Contribution of donor age to the recent decrease in patient s[r]
4. Serfaty L, Aumaitre H, Chazouilleres O, Bonnand AM, Rosmorduc O, Poupon RE, et al. Determinants of outcome of compensated hepatitis C virus-related cirrhosis. Hepatology 1998;27:1435-1440. 5. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, Urushihara A, Ki[r]
with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia. J Hepatol. 2006;44(1):97-103. 10. Drusano GL, Preston SL. A 48-week duration of therapy with pegylated interferon alpha 2b plus ribavirin may be too short to maximize[r]
examined. 2. Materials and Methods Serum samples This study was conducted in conformity with Ethical Guidelines for Clinical Studies by the Ministry of Health, Labour and Welfare. Serum samples were collected from 40 patients (25 males and 15 females) visiting Kobe University Hospital from January t[r]
association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology 2002;122:889-96. 10. Berenguer M, Prieto M, San Juan F, Rayon JM, Martinez F, Carrasco D, Moya A, Orbis F, Mir J, Berenguer J. Contribution of donor age to the recent decrease in patient s[r]
We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymor-phisms in nucleotide excision repair pathway genes, focusing on x[r]
2) and Western blotting (Figure 3) only in subjects randomized to exercise. This confirmatory step could only be done in a small sample of exercise subjects (n=5) for whom skeletal muscle tissue was available. Figure 2 Int. J. Med. Sci. 2006, 3 87shows the immunohistochemical determination o[r]
was not significant in the multivariate analysis for hyperhomocysteinemia. Table 4 shows the ORs and 95% CIs for folate ≤ 4 mg/ml, adjusted for the same factors. Gastric atro-phy decreased a risk of lower serum folate (adjusted OR=0.21, 95% CI, 0.05-0.78). Smoking status was a significant factor of[r]
concentration expressed as a relative fold change compared to control HepG2 cells (not exposed to ethanol). White and black bars represent 6 and 24 hr exposure times, respectively. Results are the mean of six different experiments (n=6). Error bars represents standard deviations. Significance[r]