BÁO CÁO KHOA HỌC: "PHENOTYPE AND FUNCTIONAL EVALUATION OF EX VIVO GENERATED ANTIGEN-SPECIFIC IMMUNE EFFECTOR CELLS WITH POTENTIAL FOR THERAPEUTIC APPLICATIONS" PPS
Tìm thấy 10,000 tài liệu liên quan tới tiêu đề "báo cáo khoa học: "Phenotype and functional evaluation of ex vivo generated antigen-specific immune...":
Ex vivo activation and expansion of lymphocytes for adoptive cell therapy has demonstrated greatsuccess. To improve safety and therapeutic efficacy, increased antigen specificity and reduced non-specific response of the [r]
domain is also essential for receptor binding becausecleavage of peptides from the N terminus by extra-cellular proteases regulates chemokine bioavailability byeither increasing or decreasing the biological activity ofthe chemokine [17]. Furthermore, prokineticins arehighly basic. Inde[r]
=−τ,−τ +1, ,0.Equation (1.1) can be regarded as the discrete analogue of the following functionaldifferential equation with bounded delay:dxdt= Ᏺt,xt, t ≥ 0, xt(0) = x(t +0)= φ(t), −σ ≤ t ≤ 0. (1.2)Almost periodic solutions of (1.2) have been discussed in [1]. The aim of[r]
REVIE W Open AccessFuture research and therapeutic applications ofhuman stem cells: general, regulatory, andbioethical aspectsAntonio LirasAbstractThere is much to be investigated about the specific characteristics of stem cells and about the e[r]
analysis of plasma samples from restrained rats injected with peptide suggest the efficacy of thepeptide increases under conditions of high enzyme activity.Conclusion: Modeling studies by others have shown that uncompetitive inhibitors may be optimalfor enzyme inhibition[r]
Viral reverse transcriptases and RNA-dependent RNApolymerases (RDRP) show the highest mutation ratesfound in nature. Diversity generated allows these virusesto evade host defenses and poses a key problem in vaccinedesign. Infected individuals develop a titanic fight toavoid vira[r]
Some clones produced a TH0 profile of cytokines (simultaneous release of IL-4 and IFN-γ). A TH2 orientation was frequent in CD4+ clones while CD8+ clones were usually TH1 and often cytotoxic. Drug presentation to T cell was MHC-restricted, usually as expected by HLA class[r]
BioMed CentralPage 1 of 4(page number not for citation purposes)Virology JournalOpen AccessHypothesisOvercoming viral escape with vaccines that generate and display antigen diversity in vivoAlbert García-QuintanillaAddress: Atanasio Barrón 14, P4-5A, 41003 Sevilla,[r]
tissues was assessed by phospho-RTK array and immunohistochemistry, respectively. The inhibition effects ofSU11274 on RMS cells were studied with regard to intracellular signaling, cell proliferation, cell cycle and cellmigration.Results: A high level of phosphoryl[r]
HER-2/neu was used to prepare the cDNA. Extracellu-lar domain (ECD) and intracellular domain (ICD) ofHER-2/neu were amplified using specific primers.ECD-forward: 5’ AAA CTC GAG ATG GAG CTGGCG GCC TTG T 3’ and reverse: 5’ CTT AAG CTTCGT CAG AGG GCT GGC TCT CT 3’ ;ICD-forward:5’ A[r]
neu-specific T cell responses were determined by using IFN-g ELISA. Expression of IFN-g Ra in the tumors wasdetermined by immunohistochemistry analysis of paraffin-embedded tissues.Results: We determined that majority of (10 of 12) patients with HER-2/neu ne[r]
activity, which can alter the adaptive immune response,they may actually interfere with the host’s ability toclear the infection. There are a lot of beneficial biomedi-cal applications for using nanomaterials, but careful con-sideration to avoid potential un[r]
33. Kochenderfer JN, Yu Z, Frasheri D, Restifo NP, Rosenberg SA: Adoptivetransfer of syngeneic T cells transduced with a chimeric antigenreceptor that recognizes murine CD19 can eradicate lymphoma andnormal B cells. Blood 2010, 116:3875-3886.34. Kochenderfer JN, Wilson WH[r]
18. Koon EC, Ma PC, Salgia R, Welch WR, Christensen JG, Berkowitz RS, Mok SC:Effect of a c-Met-specific, ATP-competitive small-molecule inhibitorSU11274 on human ovarian carcinoma cell growth, motility, andinvasion. Int J Gynecol Cancer 2008, 18:976-984.19. Cao L, Yu Y, Darko I, Currie[r]
lineage restrictions (called transdifferentiation). For example, HS cells may be converted into neurons as well as germ cells. This feature may provide a means to use tissue stem cells derived directly from a patient for therapeutic purposes, thereby elimina[r]
REVIEW ARTICLEIt is all about resolutionMeeting report based upon presentations at the 10th InternationalGlobal BioMillennium 2006 symposium on molecular cell biology(Tbilisi, Georgia)Hermona Soreq1and Alik Honigman21 Department of Biological Chemistry, The Hebrew University of Jerusal[r]
immune regulation. We identified miRs differentially regulated between type-1 and type-2 T cells, and determinedhow the expression of such miRs is regulated.Methods: We performed miR microarray analyses on in vitro differentiated murine T helper type-1 (Th1) and[r]