BÁO CÁO Y HỌC: " PREDICTING TRANSCRIPTION FACTOR ACTIVITIES FROM COMBINED ANALYSIS OF MICROARRAY AND CHIP DATA: A PARTIAL LEAST SQUARES APPROACH" POTX
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Synthesis Kit (Affymetrix). Fifteen micrograms of labeled and fragmented cRNA were subsequently hybridized to a Human Genome U133 plus 2.0 microarray (Affymetrix). After the hybridization, the DNA microarrays were washed and stained on a Fluidics Station (Affymetrix) according to manufacturer[r]
change in muscle strength (r=0.73, P=0.001). Group assignment was be the only independent predictor of hSGLT3 transcript levels, explaining 68% of its variability (P=0.01). Our data show that hSGLT3, but not GLTU4, expression was enhanced in skeletal muscle after 16 weeks of resistance training. Thi[r]
QuantiTect SYBR green RT-PCR kit (Qiagen, Hilden, Germany). Specific primers for transcription factor (AP1, SRF, Elk1, Stat1 and NFκB) and members of the Fas receptor signaling pathway (Fas receptor, Fas Int. J. Med. Sci. 2006, 3 162ligand, FADD and caspase 8) were used. Primer design was performed[r]
Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the 1045 patients enrolled into the initial “lead-in” phase had biopsy proven cirrhosis. Preliminary results show t[r]
there is data suggesting that obesity accelerating fibrosis. 6. Research Direction Although significant advances in therapeutic options have improved the outcome in the management of HCV infection, many challenges remain ahead. The proportion of chronic HCV not responding to the available drugs is f[r]
95% confidence interval (CI) = 1.14 - 1.49). We found a protective effect of the XPA 23G/G genotype (OR = 0.75, 95% CI = 0.59 - 0.95). Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation[r]
Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the 1045 patients enrolled into the initial “lead-in” phase had biopsy proven cirrhosis. Preliminary results show t[r]
Germany). HDL was measured following precipitation of apoB containing lipoproteins with phosphotungstate (Boehringer Mannheim). Apoliprotein AI (Apo AI) and Apo B were measured using the Beckmann Array 360 (Beckmann Instruments). Genotyping DNA was extracted from white blood cells using standard met[r]
by all nucleated cells and is secreted into the blood at a constant rate [1, 2]. Cys-C is freely filtered through the normal glomerular membrane and completely reabsorbed, followed by catabolization by the proximal tubular cells [1, 2]. The biological fates of Cys-C are favorable as an endoge[r]
to compute intake of red meat (pork, beef, lamb, organ meat), poultry (chicken, duck, goose), and total unprocessed meat (red meat and poultry combined). We also obtained information on the frequency of consumption of processed meat. Processed meats included smoked meat/bacon, salted meat/preserved[r]
1. INTRODUCTION Hb J-Meerut results from a C ->A mutation (GCG->GAG) at codon 120 of the α1 or α2 globin gene, changing the alanine to glutamic acid at residue 120 of the α chain [1,2,3]. This variant was first reported in two sisters from Meerut, Utlar Pradesh, India [1][r]
group relegated to the same caloric-restricted diet as the Test group. Many published studies concerning methods to combat obesity provide only scale weight loss as the principal end point. The assumption that scale weight loss is synonymous with fat loss, however, is not al-ways true [26,27]. Scale[r]
treatment, but relapse occurs frequently once treatment is discontinued.[70] Other frequent extrahepatic manifestations found in patient with chronic HCV infection are membranoproliferative glomerulonephritis, porphyria cutaneous tarda, lichen planus, and vitiligo. There is also some data that sugge[r]
immunosuppression on recurrent HCV [1,4]. However, this is extremely difficult to achieve in most patients. In the post-liver transplant setting the differential diagnosis of elevated liver chemistry tests is broad and includes acute cellular or chronic ductopenic rejection, bacterial or viral (CMV[r]
immunosuppression on recurrent HCV [1,4]. However, this is extremely difficult to achieve in most patients. In the post-liver transplant setting the differential diagnosis of elevated liver chemistry tests is broad and includes acute cellular or chronic ductopenic rejection, bacterial or viral (CMV[r]
FBW7, FBXW7) has recently emerged as a potent new potential tumor suppressor gene [1, 2]. The highly conserved protein consists of an NH2 terminal F-box and seven WD40 repeats in the COOH terminal region and acts as an adaptor protein providing substrate specificity for SCF (Skp–Cullin–F-box)[r]
protein degradation. Metabolism 1997; 46: 673-9. 25. Baulieu EE, Robel P. Dehydroepiandrosterone (DHEA) and de-hydroepiandrosterone sulfate (DHEAS) as neuroactive neuros-teroids. Proc. Natl Acad Sci USA. 1998; 95: 4089-91. 26. Yorek MA, Coppey LJ, Gellett JS, et al. Effect of treatment of diabetic r[r]