BÁO CÁO Y HỌC: "HEDGEHOG OVEREXPRESSION LEADS TO THE FORMATION OF PROSTATE CANCER STEM CELLS WITH METASTATIC PROPERTY IRRESPECTIVE OF ANDROGEN RECEPTOR EXPRESSION IN THE MOUSE MODEL" PPS
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sections shown in the upper pictures. (B) Tumor formation induced by Hedgehog overexpression (arrowheads in (b) indicate tumor mass), ascompared to vehicle control (arrowhead in (a)). The prostate gland displayed GFP signals at da[r]
AbstractBackground: Ectopic chondrogenesis and ossification were observed in a degenerativecollagenase-induced calcific tendinopathy model and to a lesser extent, in a patellar tendontraumatic injury model. We hypothesized that expression of bone morp[r]
Atlas image 2.0.1. After grid assignment the adjustedintensity for each gene was calculated by subtracting thebackground. This value was used as the input for thegenespring 6.1 program (Silicon Genetics, Redwood City,CA, USA), which allows multifilter comparisons usingdata from differen[r]
million people are chronically infected with HBV and more than one third of these individuals will develop into serious liver diseases such as primary hepatocellular carcinoma (HCC), if left untreated, which causes an estimated 1 million deaths annually [4]. Therefore, clarification
vation of NANOG and OCT4 has recently been identi-fied in an in vitro model system when both t(4;11) fusionproteins were present. This finding was then validated ininfant and adult t(4;11) leukemia patients [23]. Thus, theswitch between cell growth and quiescence in MLL-med[r]
tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmö Diet and Cancer Study and Malmö Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathol[r]
In this article, we aimed to characterize the diffuse gastric cancer cells with MRI and transcriptomic data. We hypothesized that gene expression pattern is associated with the phenotype of the cells and that the heterogeneous enhancement pattern and the high tumorigenicity of SNU484 can be modulate[r]
ondary antibody. (B) Densitometric quantification of (A) (n ¼ 3). (C) Determination of PKB activity as the amount of phosphorylated GSK3a ⁄ bproduct. (D) Densitometric quantification of (C) (n ¼ 3). (E) Western immunoblot profiles of PDK-1, PKN and p-PKN after[r]
metastases are associated with significant morbidityincludi ng pain, pathological fracture and cord compres -sion, and the median survival is 20 months [2]. Thedemands on health care resources can be great, and it istherefore important that accurate methods are availableto monitor ther[r]
indicating that uPA and c-met negative regulation might depend on miR-23b expression. Transfection of miR-23b molecules in HCC cells(SKHep1C3) led to inhibition of protein expression of the target genes andcaused a decrease in cel[r]
the manuscript. KNZ designed and coordinated theresearch efforts and edited the manuscript. All co-authorsread and approved the final manuscript.AcknowledgementsThis work was funded in part by a National Health and Medical Research Council of Australia Industry Res[r]
neurochemistry promises great insights into a level of neuralorganization that could have never been studied with either tech-nique alone. My talk will focus on (a) spatially resolved fMRI/MRSI; (b) the study of in vivo connectivity using fMRI and elec-trical micro[r]
The deduced protein sequence of selenoprotein M (14 kDa) shows charac-teristic features of metazoan selenoproteins. The spicule-associated protein(26 kDa) comprises six characteristic repeats of 20 amino acids, composedof 10 distinct hydrophobic regions ( 9 amino[r]
The m4 sequence (Fig. 7B) bound several complexes,although competition analysis with the ‘wild-type’ andmutant m4 revealed only one complex to be specific.The identity of this, presumably Ets family member,remains to be determined. The pattern <[r]
was investigated in PrPC-transfected gastric cancer cells treated with LY294002 (10 lM) or Akt siRNA (0.2 lg). b-actin was used as a loadingcontrol. Autoradiograms were quantified by densitometry, and gene or protein levels were calculated relative to the amo[r]
Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) Strategies for Stem Cell Replacement Stem cell transplantation is not a new concept and it is already part of established medical practice. Hematopoietic stem cells ([r]