A REFRACTORY CASE OF CDK4-AMPLIFIED SPINAL ASTROCYTOMA ACHIEVING COMPLETE RESPONSE UPON TREATMENT WITH A PALBOCICLIB-BASED REGIMEN: A CASE REPORT

published by Venkataramana et al. and Dinakar et al. which included MR imaging [ 15 , 16 ].
Specific to spinal extramedullary pilocytic astrocytoma in adults, in 2005 Bohner et al. reported on a case of a 25 year old male with no previous diagnosis of[r]

percutaneous transthoracic needle biopsy (Figure 1B)performed on a left lower lobe posterior segment meta-static lesion. The patient underwent FOLFOX-4 (oxali-platin 85 mg/m2IV over 2 hours D1; leucovorin 200mg/m2ove r 2 hrs, D1, 2; 5-fluorouracil (5-FU) 400 mg/m2IV bolus, and 5-FU 600 mg/m2I[r]

This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formattedPDF and full text (HTML) versions will be made available soon.Successful treatment of severe accidental hypothermia with cardiac arrest for along time using cardiopulmonary bypa[r]

BioMed CentralPage 1 of 4(page number not for citation purposes)Journal of NeuroinflammationOpen AccessCase reportEffect of pioglitazone treatment in a patient with secondary multiple sclerosisHarrihar A Pershadsingh*1,2, Michael T Heneka2, Ras[r]

Pancreatic cancer is among the top 5 most common cancers worldwide, but is particularly devastating due to its insidious nature. Complete surgical resection remains the only potential curative treatment, although only 20 % of patients present with a resectable tumor.

lesion (Fig. 4c, d).DiscussionAneurysmal bone cysts typically involve the long bones ofthe extremity, membranous bones of the thorax, or verte-brae [1]. Ilium is not the site of predilection for the aneu-rysmal bone cysts. In the series by Papagelopoulos et al[2], the ilium bone[r]

creatine kinase, lactic dehydrogenase, and gamma glu-tamyl transpeptidase levels were normal. Prothrombintime and INR were 76% and 1.1, respectively. Theclinical course was favorable. Repea ted neurologicalexamination revealed a gradual improvement of herstate of consciousness <[r]

lesion (Fig. 4c, d).DiscussionAneurysmal bone cysts typically involve the long bones ofthe extremity, membranous bones of the thorax, or verte-brae [1]. Ilium is not the site of predilection for the aneu-rysmal bone cysts. In the series by Papagelopoulos et al[2], the ilium bone[r]

alkaline phosphatase level (455 IU/L; normal range: 115-359) with otherwise normal liver enzyme levels. Radionu-clide bone scan showed dense uptake in the left femur(Figure 2). We diagnosed the patient as having pathologi-cal fracture secondary to monostotic Paget's disease. Asshe suffered fr[r]

Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML).

Women diagnosed with gliomas during child-bearing years may undergo fertility preservation prior to receiv- ing chemotherapy and radiation to harvest oocytes and freeze them or freeze embryos if they have a partner, since their postoperative treatment, especially chemo- therapy,[r]

Chronic myeloid leukemia can be effectively treated with BCR-ABL1 tyrosine kinase inhibitors. However, BCR-ABL1 mutations can develop and cause secondary resistance to these inhibitors.

Patients undergone kidney transplantation present higher risk of Urothelial Carcinoma (UC) development and represent a subgroup of special interest. To date, vinflunine is the only drug approved in Europe for the treatment of advanced UC after failure of platinum-based chemotherapy.

Acromegaly is a rare disease associated with an increased risk of developing cancer. Case presentation: We report the case of a 72-year-old man who was diagnosed with acromegaly (IGF-1 770 ng/ml) and breast cancer. Four years before he suffered from a colon-rectal cancer. Pituitary surgery and octre[r]

cells and variable amount of hematopoiesis. The exactmechanism by which such a process begins and evolves isnot clearly understood but various hypotheses are pro-posed. Formation of heterotopic bone is known to beassociated with some predisposing etiologies such asneuroge[r]

66:128-135.21. Fontaine K, Semonin O, Legarde JP, Lenoir G, Lucotte G: A new mutation of the noggin gene in a French Fibrodysplasia ossificans progressiva (FOP) family. Genet Couns 2005, 16:149-154.22. Lucotte G, Houzet A, Hubans C, Lagarde JP, Lenoir G: Mutations of