PH-DEPENDENT SOLUBILITY AND DISSOLUTION BEHAVIOR OF CARVEDILOL — CASE EXAMPLE OF A WEAKLY BASIC BCS CLASS II DRUG

The objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized by low solubility and high permeability, using carvedilol, a weak base with a pKa value of 7.8, as a model drug. A s[r]

The purpose of this study is to i) fabricate a biodegradable nanoparticle formulation of Ketoprofen, ii) evaluate its characteristics, iii) investigate its in vitro dissolution and in vivo pharmaceutical property. The nanoparticle formulation was prepared by spray drying method using Eudragit L100 a[r]

The direct and inverse models that were developed for the general six degrees of freedom robotic mechanism were adopted for the ACMA XR 701 robot. The necessary geometry of the ACMA robot was obtained with the described reverse engineering process. The robot ACMA XR 701 ha[r]

this brown-pigmented substance and elsewhere, these droplets could be seen surrounded by palisades of PMNs (Figure 2). On closer questioning, the patient admitted to several years of marijuana smoking through a bong. He denied use of tobacco. A provisional[r]

11 A special case of great importance to general relativity is a Lorentzian manifold, a special 12 case of a wider class of manifolds, called pseudo-Riemannian manifolds, known as a gene[r]

A number of malformations in humans have been reported in case reports, as tabulated in Table 2 . Approximately 23 cases were recorded. As with most other toxicologic dose relationships, all malformations have occurred at megadoses, on the order of 30,000 IU/day or great[r]

− Regression testing is a normal part of the program development process. Test department coders develop code test scenarios and exercises that will test new units of code after they have been written.
− Before a new version of a software product[r]

In this paper, we studied the progression of shallow water waves relevant to the variable coefficient Korteweg–de Vries (vcKdV) equation. We investigated two kinds of cases: when the dispersion and nonlinearity coefficients are proportional, and when they are not linearly dependent. In the first cas[r]

In this paper, we only focused on consider phenomenon of spontaneous symmetry breaking in the case of space dependent coupling. The results show that in the case of a coupling between the two rings is a function of single-Gaussian symmetry breaking only between rings. In contrast, in the case of a c[r]

Introduction: Master equations
All modern theories of acid–base balance in plasma are predicated upon thermodynamic equilibrium equations. In an equilibrium theory, one enumerates some property of a system (such as electrical charge, proton number, or proton acceptor sites)