BÁO CÁO Y HỌC: " IN VITRO BIOASSAY AS A PREDICTOR OF IN VIVO RESPONSE" PDF

118mouse embryonic stem (ES) cells carrying targeted mutations of BRCA1 (homozygous deletion of exons 22-24, referred to as BRCA1-/-) or BRCA2 (trEx11/ΔEx27, referred to as BRCA2-/-), Farmer et al. (2005) revealed similar sensitivity of these cells to PARP-1 inhibitors in vitro [25]. Will this work[r]

acute HCV infection persists and 4% to 20% of patients with chronic hepatitis C will develop liver cirrhosis within 20 years. In patients with liver cirrhosis, the risk to develop HCC is 1-5% per year. Current standard therapy is the combination of pegylated interferon-α (PEG-IFN-α) and ribavirin. D[r]

involved the addition of 2 to 20-times volume of distilled water to either of the two kinds of raw Japanese rice, such as unpolished or polished rice. Phase 2 involved their incubation at 100 to 190°C under the pressure of 0.01 to 0.8MPa for 60min. In phase 3, they were completely mixed by homogeniz[r]

such as poorly controlled hypertension or diabetes, obstructive pulmonary disease, or significant heart disease. Patients with autoimmune hepatitis or other conditions known to be exacerbated by interferon and ribavirin or known to have hypersensitivity to these drugs should not receive treatment. T[r]

been deleted have been developed [34, 45]. This modification reportedly has reduced toxicity and prolonged gene expression in some experiments [5, 33]. Nevertheless, we constructed a recombinant BMP9 helper-dependent adenoviral vector and found that the osteogenic potentials of this vector we[r]

relatively similar pattern to that found in the untreated control cells. The pairwise comparison analysis demonstrated four significantly up-regulated (COBRA1, ITGB4, STAU2, and HMGN3) genes and one down-regulated (ANK3) gene. All these genes exert their function on transcriptional and translational[r]

A group of 16 females, aged 80-93 years old, was divided into 2 groups according to their baseline DHEA-S lev-els: Lower Halves (N = 8) and Upper Halves (N = 8), and participated in a 4-month exercise intervention trial. Insulin response with an oral glucose tolerance test (OGTT), chol[r]

group relegated to the same caloric-restricted diet as the Test group. Many published studies concerning methods to combat obesity provide only scale weight loss as the principal end point. The assumption that scale weight loss is synonymous with fat loss, however, is not al-ways true [26,27]. Scale[r]

and persisted for more than 24 hr. This information provided a novel insight into the mechanisms of action of ethanol (1mM) in human hepatocellular carcinoma cells. Key words: Ethanol, HepG2 cells, protein kinases, signal transduction, transcription factors, gene expression 1. Introduction Ap[r]

CagA protein. Science 2002; 295: 683-6. 5. Higashi H, Nakaya A, Tsutsumi R, et al. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem 2004; 279: 17205-16. 6. Hatakeyama M. Helicobacter pylori CagA--a potential b[r]

Canada and 9149 subjects were included (4266 men and 4883 women). A high BMI was found to be a significant predictor of asthma incidence in women but not in men. The authors speculate that female sex hormones may play an important role in the aetiology of asthma and that these hormones[r]

self-monitoring, engaging in healthy food choices and physical activity, and compliance with medications and doctor’s visits [24]. Subjects in this group received phone calls every other week and came to the HNRCA for testing at baseline and 16 weeks. We chose this approach rather than an attention-[r]

12. Stuyver L, et al. Hepatitis C virus genotyping by means of 5'-UR/core line probe assays and molecular analysis of untypeable samples. Virus Res 1995, 38: 137-57. 13. Zheng X, et al. Direct comparison of hepatitis C virus genotypes tested by INNO-LiPA HCV II and TRUGENE HCV genotyping methods. J[r]

Int. J. Med. Sci. 2006, 3 47International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):47-52 ©2006 Ivyspring International Publisher. All rights reserved Review The Natural History of Hepatitis C Virus (HCV) Infection Stephen L. Chen 1 2 and Timothy R. Morgan 1 2 1. Gastroente[r]

and basal core promoter mutations on viral replicative interference. Hepatology 2001;34:404-410. 41. Crespo J, Lozano JL, Carte B, de las Heras B, de la Cruz F, Pons-Romero F. Viral replication in patients with concomitant hepatitis B and C virus infections. Eur J Clin Microbiol Infect Dis 1997;16:4[r]

the MTT assay. The results showed that hESC survivability after exposure to 25oC and 4oC for 24h was 77.3 ± 4.8 % and 64.4 ± 4.4 % respectively (significantly different, P < 0.05). The corresponding survival rates after 48h exposure to 25oC and 4oC was 71.0 ± 0.5 % and 69.0 ± 2.3 % respective[r]

Int. J. Med. Sci. 2006, 3 75International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):75-78 ©2006 Ivyspring International Publisher. All rights reserved Review Antiviral therapy of HCV in the cirrhotic and transplant candidate Steven K. Herrine, and Victor J. Navarro Divisio[r]

Int. J. Med. Sci. 2006, 3 75International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(2):75-78 ©2006 Ivyspring International Publisher. All rights reserved Review Antiviral therapy of HCV in the cirrhotic and transplant candidate Steven K. Herrine, and Victor J. Navarro Divisio[r]

improve insulin resistance and lower body fat and blood lipids are discussed and include a wide spectrum of biochemical and molecular activities that favorably affect fatty acid metabolism and cholesterol homeostasis. The biologic actions of certain constituents of soy protein, particularly c[r]

past decade. Where on one hand, this treatment has proven its effectiveness in ideal population; it has also identified some special populations by way of poor response or difficulties faced due to co morbid conditions. These special populations include patients with cirrhosis, non responders to pri[r]