BÁO CÁO Y HỌC: "Γ A NOVEL MECHANISM FOR THE REGULATION OF IFN-Γ INDUCIBLE PROTEIN-10 EXPRESSION IN RHEUMATOID ARTHRITIS" PPSX

date the mechanism of this network. However, a poor correlation between mRNA and protein abundance has also been reported [9]. Furthermore, a single gene can encode for more than one mRNA species through differential splicing, and proteins can undergo as many as 200 posttranslational m[r]

acute HCV infection persists and 4% to 20% of patients with chronic hepatitis C will develop liver cirrhosis within 20 years. In patients with liver cirrhosis, the risk to develop HCC is 1-5% per year. Current standard therapy is the combination of pegylated interferon-α (PEG-IFN-α) and ribavirin. D[r]

and persisted for more than 24 hr. This information provided a novel insight into the mechanisms of action of ethanol (1mM) in human hepatocellular carcinoma cells. Key words: Ethanol, HepG2 cells, protein kinases, signal transduction, transcription factors, gene expression 1. Introduction Ap[r]

20. Hwang SJ, Luo JC, Chu CW, et al. Hepatic steatosis in chronic hepatitis C virus infection: Prevalence and clinical correlation. J Gastroenterol Hepatol 2001;16:190-5. 21. Lonardo A, Adinolfi LE, Loria P, et al. Steatopsis and hepatitis C virus: Mechanisms and significance for hepatic and[r]

Int. J. Med. Sci. 2006, 3 84International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(3):84-91 ©2006 Ivyspring International Publisher. All rights reserved Research paper Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance t[r]

Int. J. Med. Sci. 2006, 3 108International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(3):108-111 ©2006 Ivyspring International Publisher. All rights reserved Research paper Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk[r]

Corresponding address: Jin Zhong Li, D.V.M. Ph.D., Department of Neurological Surgery, University of Virginia Health System, P. O. Box 800212, Charlottesville, Virginia 22908, USA Received: 2006.05.02; Accepted: 2006.05.31; Published: 2006.06.01 Osteogenic potentials of some recombinant human bone m[r]

protein degradation. Metabolism 1997; 46: 673-9. 25. Baulieu EE, Robel P. Dehydroepiandrosterone (DHEA) and de-hydroepiandrosterone sulfate (DHEAS) as neuroactive neuros-teroids. Proc. Natl Acad Sci USA. 1998; 95: 4089-91. 26. Yorek MA, Coppey LJ, Gellett JS, et al. Effect of treatment of diabetic r[r]

Int. J. Med. Sci. 2007, 4 28International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2007 4(1):28-35 © Ivyspring International Publisher. All rights reserved Research Paper Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. R[r]

and basal core promoter mutations on viral replicative interference. Hepatology 2001;34:404-410. 41. Crespo J, Lozano JL, Carte B, de las Heras B, de la Cruz F, Pons-Romero F. Viral replication in patients with concomitant hepatitis B and C virus infections. Eur J Clin Microbiol Infect Dis 1997;16:4[r]

what appears to be a relatively weak, ineffective immune response since it is inadequate to clear the virus. Since immunologic mediated inflammation is thought to be the mechanism of progressive fibrosis, it is surprising that immune suppression does not ameliorate the disease at the expense[r]

Miles Laboratories, Elkhart, IN), and frozen in isopentane cooled in liquid nitrogen. Transverse sections (10µm) were cut using a Leica CM1850-Cryostat (Leica Microsystem, Nussloch, Germany). Staining for myofibrillar adenosine triphosphatase (mATPase) was done at pH 4.3 [28]. Type I a[r]

University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 Japan. Tel: +81-52-744-2133, Fax: +81-52-744-2971, e-mail: y-goto@med.nagoya-u.ac.jp Received: 2006.09.22; Accepted: 2006.10.25; Published: 2006.11.01 Background: Various single nucleotide polymorphisms (SNPs) have ex[r]

Int. J. Med. Sci. 2006, 3 148International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3(4):148-151 ©2006 Ivyspring International Publisher. All rights reserved Short Research Communication Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism Dani[r]

by all nucleated cells and is secreted into the blood at a constant rate [1, 2]. Cys-C is freely filtered through the normal glomerular membrane and completely reabsorbed, followed by catabolization by the proximal tubular cells [1, 2]. The biological fates of Cys-C are favorable as an endoge[r]

24, the likelihood of an SVR is virtually nil and treatment can be stopped or continued with the only aim to slow liver disease progression in patients with a severe prognosis, without any hope to eradicate infection (Figure 1A) [18, 22]. Ongoing trials are studying whether a pr[r]

served in cod protein-fed and soy protein-fed animals may be due to decreased pancreatic insulin release and/or increased hepatic insulin removal. Recently, Davis et al evaluated effects of casein and soy protein on body weight, plasma cholesterol, and insulin sensi-tivity in male lean SHHF (+/cp) r[r]

3-2. XPA G23A polymorphism and lung cancer risk The heterotrimeric replication protein A (RPA) is required for NER and may play an important role in the damage recognition process. The XPA protein is required for NER and is involved in the DNA damage recognition process. Both RPA and XPA pref[r]

As an example we presented the finding that maternal use of loratadine in early pregnancy was associated with a roughly doubled risk for infant hypospadias. We concluded: “The finding can still be random, but causality cannot be dismissed, even though the mechanism of action is not understood[r]

new urate oxidase. [12] In fact, the old and the new urate oxidase do not significantly differ from a pharmacodynamic point of view; the only difference consists in the reduction of rasburicase’s adverse effects. Studies have reported the presence of antibodies antirasburicase in some pa-tien[r]