Corresponding address: Jin Zhong Li, D.V.M. Ph.D., Department of Neurological Surgery, University of Virginia Health System, P. O. Box 800212, Charlottesville, Virginia 22908, USA Received: 2006.05.02; Accepted: 2006.05.31; Published: 2006.06.01 Osteogenic potentials of some recombinant human bone m[r]
and persisted for more than 24 hr. This information provided a novel insight into the mechanisms of action of ethanol (1mM) in human hepatocellular carcinoma cells. Key words: Ethanol, HepG2 cells, protein kinases, signal transduction, transcription factors, gene expression 1. Introduction Ap[r]
the intracellular pool to the plasma membrane [5, 6]. However, sustained insulin deficiency leads to a decreased number of GLUT4 transporters, resulting in impaired responsiveness of glucose transport to both insulin and exercise [4, 7]. People with type 2 diabetes have been shown to have def[r]
sity and is influenced by genetic and environmental factors, and in particular, changes in diet and physical activity [8,9]. Lipid abnormalities associated with obe-sity include increased overall production of lipids with elevated concentrations of fatty acids, triacyl-glycerols, and low-density lip[r]
date the mechanism of this network. However, a poor correlation between mRNA and protein abundance has also been reported [9]. Furthermore, a single gene can encode for more than one mRNA species through differential splicing, and proteins can undergo as many as 200 posttranslational m[r]
acute HCV infection persists and 4% to 20% of patients with chronic hepatitis C will develop liver cirrhosis within 20 years. In patients with liver cirrhosis, the risk to develop HCC is 1-5% per year. Current standard therapy is the combination of pegylated interferon-α (PEG-IFN-α) and ribavirin. D[r]
is the second most common cause of death from cancer [1]. Helicobacter pylori (H. pylori) strains carrying the cytotoxin-associated gene A (cagA) gene are strongly associated with increased risk of gastric adenocarcinoma [2]. However, only some of those infected developed H. pylori-related di[r]
pattern. It is possible that participants who have been diagnosed with a chronic disease may have changed their diet. To address this concern we adjusted for the presence of chronic disease (CHD, cancer, and stroke) and hypertension throughout the analyses. We also repeated the analyses exclu[r]
tion. Exercise is a known stress condition that con-sumes muscle glycogen rapidly. During the recovery period following exercise, the whole-body glucose tolerance and the rate of muscle glycogen storage in-creases simultaneously, resulting in glycogen super-compensation [5]. This normal adapt[r]
3. Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Na-goya, 461-8673 Japan Correspondence to: Simon Itou, Department of Preventive Medicine / Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Ts[r]
the MTT assay. The results showed that hESC survivability after exposure to 25oC and 4oC for 24h was 77.3 ± 4.8 % and 64.4 ± 4.4 % respectively (significantly different, P < 0.05). The corresponding survival rates after 48h exposure to 25oC and 4oC was 71.0 ± 0.5 % and 69.0 ± 2.3 % respective[r]
globin gene did not reveal any abnormality, shown in Figure 2. However, nucleotide sequencing of the α1-globin gene showed a C ->A mutation at codon 120 in exon–3, thus identifying the variant as Hb J-Meerut [ α120 (H3) Ala -> Glu], as illustrated in Figure 1. Figure 1: S[r]
what appears to be a relatively weak, ineffective immune response since it is inadequate to clear the virus. Since immunologic mediated inflammation is thought to be the mechanism of progressive fibrosis, it is surprising that immune suppression does not ameliorate the disease at the expense[r]
Int. J. Med. Sci. 2006, 3 1114. Skogsberg J, Kannisto R, Roshani L, Gagne E, Hamsten A, Larsson C, Ehrenborg E. Characterization of the human peroxisome proliferator activated receptor delta gene and its expression. Int J Mol Med. 2000; 6: 73-81. 5. Olivier WR, Shenk JL, Snaith MR, Russell CS[r]
hypothesis and at the surveillance process we study a large number of “exposures” (in this case drugs) and many outcomes (in this case different types of congenital malformations) it is to be expected that a number of apparently significant associations will occur. In this situation th[r]
Synthesis Kit (Affymetrix). Fifteen micrograms of labeled and fragmented cRNA were subsequently hybridized to a Human Genome U133 plus 2.0 microarray (Affymetrix). After the hybridization, the DNA microarrays were washed and stained on a Fluidics Station (Affymetrix) according to manufacturer[r]
among natural weight loss supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbo-hydrate-derived calories and/or by providing resistant starches to the lower gastro[r]