HIGH INFILTRATION OF MAST CELLS POSITIVE TO TRYPTASE PREDICTS WORSE OUTCOME FOLLOWING RESECTION OF COLORECTAL LIVER METASTASES

Accumulation of tumor-infiltrating mast cells (MCs) predicts poor survival in several cancers after resection. However, its effect on the prognosis of patients with colorectal liver metastases (CRLM) is not known.

Reported studies on colorectal cancer tissue display amplifications at chromosome 8q, 13 and 20q, and dele- tions at chromosome 8p, 17p and 18q [15 – 17]. Amplifi- cations at chromosome 13 and 20 were detected in 11 of our 20 patients at tumour tissue analyses while such al- terations[r]

Methods: An in vitro cell culture model expressing SOX2 was used to investigate the functional role of SOX2 in CRC. In vitro findings were verified using RNA from fresh frozen tumor tissue or immunohistochemistry on formalin fixed paraffin embedded (FFPE) tumor tissue from a cohort [r]

Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs).

Hepatocellular carcinoma has a dismal prognosis due to recurrence rates of up to 70% after curative resection. Early recurrence is driven by synchronous microscopic intrahepatic metastases. The predictive value of histological parameters is discussed controversially and adjuvant therapy is not estab[r]

cells and variable amount of hematopoiesis. The exactmechanism by which such a process begins and evolves isnot clearly understood but various hypotheses are pro-posed. Formation of heterotopic bone is known to beassociated with some predisposing etiologies such asneuroge[r]

After curative-intent surgery for colorectal liver metastases (CRLM), liver recurrence occurs in more than 60% of patients, despite the administration of perioperative or adjuvant chemotherapy. This risk is even higher after resection of more than three CRLM.

cells and variable amount of hematopoiesis. The exactmechanism by which such a process begins and evolves isnot clearly understood but various hypotheses are pro-posed. Formation of heterotopic bone is known to beassociated with some predisposing etiologies such asneuroge[r]

This study was carried out to determine the prognostic significance of preoperative peripheral epithelial cell adhesion molecule- positive (EpCAM + ) circulating tumor cell (CTC) and T regulatory (Treg) cell levels in hepatocellular carcinoma (HCC) patients for the prediction of postoperative recurr[r]

Chapter 087. Gastrointestinal Tract Cancer (Part 13) Radiation therapy to the pelvis is recommended for patients with rectal cancer because it reduces the 20–25% probability of regional recurrences following complete surgical resection of stage II or III tumors, e[r]

cancer-specific survival in patients treated by Cisplatin-based inductionchemotherapy for locally advanced head and neck squamous cellcarcinoma. Clin Cancer Res 2007, 13:3855-3859.29. Jun HJ, Ahn MJ, Kim HS, Yi SY, Han J, Lee SK, Ahn YC, Jeong HS, Son YI,Baek JH, Park K: ERCC1 expression as a predic[r]

any superiority of laparotomy.For example, randomized studies comparing laparoscopy and mini-laparotomyfor cholecystectomy have failed to demonstrate the superiority of one approachover the other [51, 52]. However, few would dispute that laparoscopy is now thestandard approach f[r]

In treatment-refractory liver dominant metastatic colorectal cancer, the role of liver directed therapies still is unclear. We sought to determine a prognostic score for Y90 radioembolization in these patients.

from heat-stressed tumor cells, initiates antitumor immunity by inducingtumor cell chemokine production and activating dendritic cells via TLR4pathway. The journal of immunology 2009, 182(3):1449.42. Castelli C, Rivoltini L, Rini F, Belli F, Testori A, Maio M, Mazzaferro V, Copp[r]

response and survival for gastric cancer patients receiving combinationcisplatin and fluorouracil chemotherapy. J Clin Oncol 1998, 16:309-316.21. Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg KD,Groshen S, Tsao-Wei DD, Danenberg PV, Lenz HJ: ERCC1 and thymidylatesynthase mRNA[r]

level of intracellular PGs did not reach a plateau, asobserved for the proteases (Fig. 3B). Rather, the levelof cell-associated PGs showed a continuous increaseover time (Fig. 6A). Notably, the latter is in goodagreement with the relatively late appearance of May–Gru¨nwald ⁄ Giemsa-[r]

Despite the clinical significance of liver metastases, the difference between molecular and cellular changes in primary colorectal cancers (CRC) and matched liver metastases is poorly understood.

risk for postoperative complications and death. The surgical risk becomes unaccept-ably high in some patients with congestive heart failure, severe chronic obstructivepulmonary disease, and chronic renal failure [10, 11].Evaluation of Tumor ExtentThe assessment of tumor extent i[r]

Chapter 10Ultrasound-Guided Liver Resectionfor Hepatocellular CarcinomaGuido TorzilliKeywords Hepatic surgery · Ultrasound-guided percutaneous therapies · Liverresection · Contrast-enhanced Ultrasonography performed intraoperativelyIntroductionHepatic surgery performed without a parenchyma-sp[r]

cent of the implants did not show parenchymal infiltra-tion, but it is important to know this information before surgery, as that patients with parenchymal infiltration require a liver resection [11,28]. The increase in CA125 is also useful in the diagnosis of

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